Disentangling the relationship between intrauterine exposures and offspring growth in mid-childhood [0.03%]
解开宫内环境与学龄前儿童生长发育之间关系的谜题
Kym-Mai Nguyen,Roya Karimi,Marc Vaudel et al.
Kym-Mai Nguyen et al.
Background: Conventional epidemiological studies have suggested that lower birthweight and adverse pregnancy events are associated with later life obesity and cardiometabolic disorders, suggesting that intrauterine factor...
The therapeutic effect of novel endoscopic submucosal dissection with lymph node dissection surgery on T1 ESCC: A single center, prospective, and nested case-control study [0.03%]
一种新型内镜黏膜下剥离联合淋巴结清扫术治疗T1期食管鳞癌的疗效：单中心前瞻性嵌套病例对照研究
Yiqing Mei,Jianning Zhou,Weiwei Jiang et al.
Yiqing Mei et al.
Background: Endoscopic submucosal dissection is effective for treating T1 early esophageal squamous cell carcinoma. However, there is a risk of lymph node metastasis . Standard radical surgery may be overtreatment for T1 ...
A multi-modal parcellation of human globus pallidus and its implications for symptom prediction and stratification in Parkinson's disease [0.03%]
多模态划分帕金森病丘脑底核的方法及其在症状预测和分类中的应用
Tianyi Yan,Kexin Wang,Ziteng Han et al.
Tianyi Yan et al.
Background: The globus pallidus (GP) is a critical basal ganglia nucleus for motor and cognitive control. However, traditional single-modality parcellations provide an incomplete understanding of its internal organization...
Association between air pollution exposure and increased chronic kidney disease risk: the modifying effects of genetic susceptibility, transcriptomic, and proteomic signatures [0.03%]
空气污染暴露与慢性肾脏病风险增加的关系：基因易感性、转录组和蛋白质组标志物的调节作用
Jian Lu,Shuaigang Sun,Xinru Shang et al.
Jian Lu et al.
Background: Air pollution exposure is increasingly recognized as a risk factor for chronic kidney disease (CKD), but the underlying mechanisms, especially the complex gene-environment interactions as reflected in genetic ...
Structural connectome architecture and biological vulnerability shape cortical atrophy in cocaine use disorder [0.03%]
柯克恩使用障碍中的结构连接体架构和生物学脆弱性塑造皮层萎缩
Ziteng Han,Tiantian Liu,Kexin Wang et al.
Ziteng Han et al.
Background: Cocaine use disorder (CUD) is highly prevalent and characterized by widespread gray matter atrophy across the cerebral cortex. Yet, it remains unclear whether and how connectome-based circuits and biological f...
Combined targeting of VISTA and sorafenib activates T cell-mediated anti-tumor immunity via the NF-κB/TNF axis in hepatocellular carcinoma [0.03%]
联合靶向VISTA和索拉非尼通过NF-κB / TNF轴激活T细胞介导的肝癌抗肿瘤免疫反应
Jie Wang,Xueni Zeng,Wenwen Liu et al.
Jie Wang et al.
Background: Hepatocellular carcinoma (HCC) is a highly aggressive malignancy, with most patients diagnosed at advanced stages. Sorafenib, a multi-targeted tyrosine kinase inhibitor, remains a first-line therapy but has li...
Placental insulin-mTOR and stress-inflammatory signaling patterns are associated with childhood adiposity [0.03%]
胎盘胰岛素-mTOR和应激-炎症信号模式与儿童肥胖有关
Ellen C Francis,Kristen E Boyle,Lauren E Gyllenhammer et al.
Ellen C Francis et al.
Background: Placental signaling pathways regulate nutrient transport and fetal growth, with potential long-term consequences for offspring metabolic health. Most prior human studies have focused on individual placental ma...
Genetic predisposition for depression, psychosocial and behavioural factors and premenstrual symptoms: a cross-sectional study among young women in China [0.03%]
遗传易感性、心理社会和行为因素与经前症状的关系：对中国年轻女性的横断面研究
Yu Zhao,Qing Pan,Min Chen et al.
Yu Zhao et al.
Background: Premenstrual disorders (PMDs) affect approximately one in three women of reproductive age and have a substantial impact on daily functioning and mental health. Given the challenges observed in diagnosis and cl...
Waist circumference and grip strength and their joint relations to type 2 diabetes incidence in UK Biobank [0.03%]
英国生物样本库中腰围和握力以及它们与2型糖尿病发病率的联合关系
Johanna Wirler,Michael J Stein,Hansjörg Baurecht et al.
Johanna Wirler et al.
Background: Waist circumference and grip strength are each associated with type 2 diabetes (T2D) risk, but their joint associations have been less well studied. ...
Smartphone-based lightweight AI system for real-time multiple anterior segment disease screening: development and real-world validation [0.03%]
基于智能手机的轻量级AI系统用于实时多病种眼前节疾病的筛查：研发与真实世界验证
Yuwen Liu,Changsheng Xu,Shinan Wu et al.
Yuwen Liu et al.
Background: Anterior segment diseases are a major global cause of preventable blindness, especially in regions with limited access to specialized ophthalmic care. Diagnosis typically requires slit-lamp biomicroscopy, crea...