Digenic inheritance of mutations in SPG7 and AFG3L2 causes motor neuron and cerebellar disorders [0.03%]
Mehrdad A Estiar,Eric Yu,Parizad Varghaei et al.
Mehrdad A Estiar et al.
Background: Biallelic SPG7 mutations cause one of the most common forms of hereditary spastic paraplegia (HSP). Several reports have suggested that heterozygous SPG7 variants may also play a role in HSP, but also in amyot...
Clinical epidemiology and risk prediction of unsuccessful treatment outcomes in pulmonary tuberculosis with diabetes mellitus [0.03%]
Ping Li,Feilong Lu,Ruhong Long et al.
Ping Li et al.
Background: This study aims to characterize the epidemiological and clinical features of pulmonary tuberculosis with diabetes mellitus (PTB-DM), identify risk factors for unsuccessful treatment outcomes, and develop predi...
The need for clinical studies assessing whether weight loss improves functional outcome after stroke in diabetes [0.03%]
Ellen Vercalsteren,Michael V Mazya,Thomas Nyström et al.
Ellen Vercalsteren et al.
Background: Type 2 diabetes worsens functional outcome after stroke, severely affecting the rehabilitation processes, with no therapy available for this medical problem. ...
Multimorbidity patterns and the subsequent risk of albuminuria: findings from the Stockholm Creatinine Measurements (SCREAM) project [0.03%]
Giorgi Beridze,Patrick B Mark,Michael K Sullivan et al.
Giorgi Beridze et al.
Background: Chronic conditions often cluster together, forming distinct multimorbidity patterns. We aimed to explore how such patterns are associated with the risk of albuminuria. ...
Bilateral sequential accelerated theta-burst stimulation for treatment-resistant depression: an open-label randomized controlled trial [0.03%]
Xingxing Li,Enze Tang,Lingjiang Liu et al.
Xingxing Li et al.
Background: This study aims to evaluate the clinical effectiveness and feasibility of a novel bilateral sequential accelerated theta-burst stimulation (BS-aTBS) protocol in treatment-resistant depression (TRD) patients, c...
Targeting STE20-type kinase MST3 improves metabolic dysfunction-associated steatohepatitis without affecting hepatocellular carcinoma development in mice [0.03%]
Jingjing Zhang,Xiangdong Gongye,Lohitesh Kovooru et al.
Jingjing Zhang et al.
Background: Metabolic dysfunction-associated steatohepatitis (MASH) is a major precursor of hepatocellular carcinoma (HCC), yet the molecular mechanisms linking steatohepatitis to malignancy remain poorly defined. The STE...
Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours [0.03%]
Héléne T Cronjé,Sile Hu,Rachel Gurrell et al.
Héléne T Cronjé et al.
Background: Alcohol use disorder (AUD) represents a tremendous societal burden, yet few efficacious therapies are available and widely used. Pre-clinical and human observational data support fibroblast growth factor 21 (F...
Social isolation and 59 common health conditions: insights from observational and genetics analyses [0.03%]
Sizhi Ai,Qiqi Wu,Yu Nie et al.
Sizhi Ai et al.
Background: The impacts of social isolation on diverse health conditions and how it contributes to health risks remain unclear. We aimed to investigate the associations of social isolation with 59 health conditions among ...
Clustering depression subgroups based on dorsolateral prefrontal-subgenual anterior cingulate cortex peak functional connectivity reveals different symptom profiles and TMS treatment outcomes [0.03%]
Gai Kong,Sirui Wang,Lijiang Wei et al.
Gai Kong et al.
Background: Aberrant functional connectivity (FC) between the left dorsolateral prefrontal cortex (DLPFC) and subgenual anterior cingulate cortex (sgACC) is a replicated neural correlate of major depressive disorder (MDD)...
Understanding Japan's mortality advantage: a comparison of mortality in independent and dependent older adults in Japan and Sweden [0.03%]
Shunsuke Murata,Marcus Ebeling,Rei Ono et al.
Shunsuke Murata et al.
Background: A fundamental public health goal is that all individuals have the opportunity to reach old age with adequate care and support. Japan is the global leader in longevity, and understanding whether this advantage ...
Comparative Study
BMC medicine. 2026 Mar 23;24(1):160. DOI:10.1186/s12916-026-04786-z 2026