Penpulimab in combination with lenalidomide and R-GemOx regimen (R2-GemOx-PD1i) in relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm, phase 2 trial [0.03%]
派普珠单抗联合来那度胺和R-GemOx方案（R2-GemOx-PD1i）治疗复发或难治弥漫大B细胞淋巴瘤：一项多中心单臂II期临床试验
Jin-Hua Liang,Tong-Yao Xing,Wei-Ying Gu et al.
Jin-Hua Liang et al.
Background: This phase II clinical trial evaluated the R2-GemOx-PD1i regimen, a combination of penpulimab (a modified PD1 inhibitor) with lenalidomide and rituximab, gemcitabine, and oxaliplatin, in treating refractory or...
Quantifying lifetime risk for 1,401 infectious diseases across the diabetes spectrum using a Bayesian approach [0.03%]
基于贝叶斯方法量化糖尿病谱系中1401种传染病的终生风险
Boomer B Olsen,Martin Tristani-Firouzi,Karen Eilbeck et al.
Boomer B Olsen et al.
Background: While diabetes-related complications have been widely investigated, the burden of infectious diseases across the diabetes spectrum remains relatively understudied. ...
Risk assessment of asthma and allergic rhinitis in atopic dermatitis patients treated with biologics and JAK inhibitors: a systematic review and network meta-analysis of randomized controlled trials [0.03%]
生物制剂和JAK抑制剂治疗特应性皮炎患者哮喘和过敏性鼻炎风险的系统评价和网络meta分析
Liling Zeng,Tong Zhou,Lishan Zhang et al.
Liling Zeng et al.
Background: Numerous emerging systemic therapies, including monoclonal antibodies and Janus kinase (JAK) inhibitors, are effective for atopic dermatitis (AD). However, their effects on the incidence of airway comorbiditie...
Preclinical activity of brincidofovir in peripheral T-cell and NK/T-cell lymphoma [0.03%]
Brincidofovir用于外周T细胞和NK/T细胞淋巴瘤的抗肿瘤活性研究表明
Jason Yongsheng Chan,Elizabeth Chun Yong Lee,Kelila Xin Ye Chai et al.
Jason Yongsheng Chan et al.
Background: Brincidofovir (BCV) is a novel nucleoside phosphonate analogue with unique dual antiviral and anti-tumor properties. Methods: ...
Effects of ablation versus drug therapy on clinical outcomes and quality of life by frailty status in atrial fibrillation: a post hoc analysis of the CABANA trial [0.03%]
按照心房颤动患者衰弱状况分析导管消融治疗和药物治疗对临床结果及生活质量的影响：卡巴纳试验的事后分析
Lili Wang,Yanguang Li,Qiaoyuan Li et al.
Lili Wang et al.
Background: Frailty is highly prevalent in patients with atrial fibrillation (AF) and is associated with adverse outcomes compared with non-frail individuals. This study aimed to explore whether the effects of ablation ve...
Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis [0.03%]
精神活性物质使用与泛癌的共享遗传结构：来自大规模组间交叉性状分析的见解
Jiahang Song,Pengzhu Li,Martin Canis et al.
Jiahang Song et al.
Background: Psychoactive substance use (PSU) and cancer are frequently observed comorbidities that have reciprocal influences and shared behavioral traits of the affected patients. While, e.g., nicotine and alcohol are ma...
Genetic risk factors modulate the association between physical activity and colorectal cancer [0.03%]
遗传风险因素调节身体活动与结直肠癌的关联
Anita R Peoples,Mireia Obón-Santacana,Andre E Kim et al.
Anita R Peoples et al.
Background: Physical activity is an established protective factor for colorectal cancer (CRC), but it is unclear if genetic variants modify this effect. To investigate this possibility, we conducted a genome-wide gene-phy...
A neuroimaging biomarker for disease staging in clinically diagnosed Alzheimer's disease [0.03%]
阿尔茨海默病临床诊断的疾病分期的神经影像生物标志物
Zhuangzhuang Li,Shaozhen Yan,Kun Zhao et al.
Zhuangzhuang Li et al.
Background: Precision medicine for Alzheimer's disease (AD) requires the development of a robust management framework grounded in individualized disease staging systems. To date, only a limited number of studies have supp...
ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics [0.03%]
乳腺癌转移中ISG15驱动的免疫调节和肿瘤进展：单细胞和空间转录组学的见解
Hua Shao,Hanlu Tang,Huiying Lin et al.
Hua Shao et al.
Background: Cancer stem cells (CSCs) play a crucial role in breast cancer (BRCA) progression and lymph node metastasis. This study aimed to elucidate how CSCs reshape the immune microenvironment during metastatic dissemin...
Association of DNA methylation with hypertension and blood pressure: a 7-year longitudinal study from KORA F4/FF4 [0.03%]
DNA甲基化与高血压及血压的关系：KORA F4/FF4长达7年的纵向研究
Liye Lai,Angelina Shin Yee Jong,Thomas Delerue et al.
Liye Lai et al.
Background: Hypertension (HTN) has been linked to changes in DNA methylation. However, longitudinal epigenome-wide analyses are still limited. Methods: ...