Dynamic response by commensal E. coli two-component system Cpx contributes to C. elegans development [0.03%]
大肠杆菌共栖菌的双组分系统Cpx响应促进秀丽隐杆线虫发育
Huiyang Xiong,Beilei Hua,Huanhu Zhu
Huiyang Xiong
Background: The Caenorhabditis elegans-Escherichia coli system is advantageous for studying host-microbe interactions at the single-gene level. By screening with this system, we identified that the deletion of cpxR, an E....
Cassio Fleming,Jurian Schuijers
Cassio Fleming
Biomolecular condensates control key cellular processes, from gene expression to signal transduction, by organizing molecules through selective compartmentalization. Increasing evidence links their dysregulation to cancer, neurodegeneration...
Disentangling host genetic variation for avoidance and resistance to pathogens [0.03%]
解开宿主基因组中避开和抵抗病原体的变异因素
Caroline R Amoroso,Janis Antonovics
Caroline R Amoroso
Background: Hosts can use avoidance (e.g., behavior) to reduce their contact rates with pathogens; after contact, they can use resistance (e.g., immunity) to reduce the establishment and proliferation of an infection. Bec...
Phylogenomic tree of Cercozoa based on single-cell transcriptomes from 100 uncultured cells [0.03%]
基于单细胞转录组的Cercozoa系统发生树（基于100个未培养细胞）
Gordon Lax,Elizabeth C Cooney,Vasily Zlatogursky et al.
Gordon Lax et al.
Background: Cercozoa are single-celled eukaryotes (protists) and are part of the supergroup Rhizaria. Cercozoans have vastly different morphologies and are defined by their phylogenetic affinity. While the group includes ...
Paternal genomic history and Y-chromosome phylogeny from the Chengdu Plain reveal multiple Indigenous East Asian farmer contributions to ancient Shu and their descendants [0.03%]
成都平原父系基因组历史和Y染色体系统发育表明古代蜀及后人对原籍东亚农民的多次贡献
Lisiteng Luo,Yanling Liu,Yalan Liu et al.
Lisiteng Luo et al.
Background: The Chengdu Plain and surrounding regions (CPS) host a diverse mosaic of archaeological cultures and ethnolinguistic groups, yet the origins of these populations and the extent of Western Eurasian and East Asi...
Horizontal transfer of post-translational modifiers brings evolutionary opportunity and challenges to a conserved translation factor [0.03%]
泛素缀合酶UBR5的水平转移给高度保守的翻译因子带来了进化机遇和挑战
Tess E Brewer,Pavel Kielkowski,Jingzhi Stritzel et al.
Tess E Brewer et al.
Background: Horizontal gene transfer (HGT) is a major driver of microbial evolution, yet the influence of host cellular context on the integration and functionality of transferred genes remains underexplored. In this stud...
Alexei Yu Kostygov,Danyil Grybchuk,Donnamae Klocek et al.
Alexei Yu Kostygov et al.
Background: Trypanosomatids are parasitic flagellates best known for human pathogens causing sleeping sickness, Chagas disease, and leishmaniasis. RNA viruses infecting these protists have recently gained attention for th...
Energy metabolism and adaptation to hypoxia in the non-photosynthetic green alga Leontynka [0.03%]
无光合作用的绿藻Leontypinales的能量代谢和低氧适应性
Pia Corre,Jana Pilátová,Tomáš Bílý et al.
Pia Corre et al.
Background: Leontynka is a non-photosynthetic lineage of the order Chlamydomonadales (Chlorophyta). Although many Chlamydomonadales members encode components of the anaerobic energy metabolism, studies focused on Chlamydo...
Major transitions in early coral development: novel insights enabled by visualisation of a comprehensive transcriptomic dataset for Acropora millepora [0.03%]
全面的转录组数据集使我们能够深入了解早期造礁珊瑚发育过程中的重大转变：以蜂巢珊瑚(A.millepora)为例
Ramona Brunner,Mila Grinblat,Aurelie Moya et al.
Ramona Brunner et al.
Background: Given the ecological importance of reef-building corals (Scleractinia), it is perhaps surprising that the molecular mechanisms underlying many of the morphological and metabolic changes during their developmen...
Dragon Kill Points: applying a transparent working template to relieve authorship stress [0.03%]
dragons的杀伤点：应用透明的工作模板来缓解写作压力
April Robin Martinig,Spenser L P Burk,Szymon M Drobniak et al.
April Robin Martinig et al.
Classifying and ranking academic authorship lists is complex in practice, despite existing frameworks, and can lead to conflict. We propose Dragon Kill Points, adapted from multiplayer gaming, to track contributions throughout a project's l...