Lucia Bracesco,Delilah Hendriks,Benedetta Artegiani
Lucia Bracesco
Oncogenic fusions, arising from chromosomal rearrangements, occur in several cancers, particularly in those of pediatric origin. Advances in sequencing technologies have improved fusion detection; yet, understanding their mechanisms and tum...
Identification of neuropeptide networks involved in the ecdysis program of a crustacean model: Carcinus maenas reveal similarities and differences to insects that reflect evolutionary divergence in structure and function [0.03%]
Jodi L Hoppes,David C Wilcockson,Michael G B Hayle et al.
Jodi L Hoppes et al.
Background: Arthropods require periodic molting (ecdysis) for growth. While the neuroendocrine orchestration of ecdysis is well characterized in insects, it remains comparatively poorly understood in crustaceans. In insec...
Gene loss and vesicular transport remodeling underpin heterotrophic adaptations of scleractinian corals [0.03%]
Junyuan Li,Yang Li,Zifeng Zhan et al.
Junyuan Li et al.
Background: Azooxanthellate scleractinian corals, which lack symbiotic dinoflagellates, occur from shallow waters to deep-sea environments. In deep-sea benthic ecosystems, they serve as foundation species and are consider...
Remi N Ketchum,Edward G Smith,Leandra M Toledo et al.
Remi N Ketchum et al.
Background: Understanding how populations diverge is one of the most compelling questions in evolutionary biology but our grasp on the genomic mechanisms underpinning divergence is limited to a handful of species. Indeed,...
Che Liu,Jinbo Cheng,Xiandeng Wu
Che Liu
Phase separation has emerged as a key mechanism of cellular compartmentalization, complementing classical membrane-bound organelles. In addition to forming membraneless compartments that provide confined environments for biochemical reactio...
Tentonin 3 regulates the proliferation and migration of neural stem cells during embryonic brain development [0.03%]
Maria Al Nuilati,Kyungmin Kim,Jimin Kang et al.
Maria Al Nuilati et al.
Background: Cell fate determination during brain development, encompassing both neural stem cells (NSCs) and immature neurons, is orchestrated by complex mechanical signals. While mechanical sensing during forebrain devel...
Dynamic interplay of maternal and paternal contributions to offspring phenotype in Eurasian perch [0.03%]
Rossella Debernardis,Abhipsa Panda,Sylwia Wałdowska et al.
Rossella Debernardis et al.
Background: Parental contributions to offspring phenotype extend beyond genetic inheritance, encompassing non-genetic factors that influence early development. However, the interplay between maternal and paternal effects ...
Reconstructing mammalian lifespan evolution reveals strong phylogenetic effects and lifespan-associated genes [0.03%]
重建哺乳动物寿命进化揭示了强烈的系谱效应和与寿命相关的基因
Zhen-Na Zhang,Xue Lyu,Shan-Zhuang Niu et al.
Zhen-Na Zhang et al.
Background: Despite the extraordinary diversity in mammalian lifespans, the evolutionary trajectories and underlying molecular mechanisms governing this variation remain largely uncharacterized. ...
Effete and Cullin 4 affect nuclear organization of the gypsy chromatin insulator [0.03%]
Effete和Cullin 4影响gypsy绝缘子异染色质组织
Shue Chen,Dagyeong Yang,Elissa P Lei
Shue Chen
Backgound: Chromatin insulators demarcate the genome into distinct transcriptional domains and contribute to higher-order genome organization. In Drosophila, Su(Hw), CP190, and Mod(mdg4)67.2 are core protein components of...
LMO7-mediated ubiquitination of SIRT3 promotes osteoarthritis progression: an investigation using machine learning and molecular dynamics simulations [0.03%]
LMO7介导的SIRT3泛素化促进骨关节炎进展：基于机器学习和分子动力学模拟的研究
Qian Zhang,Jun Li,Guangchang Shan et al.
Qian Zhang et al.
Background: This study aims to inform clinical decision-making by identifying metabolism-related biomarkers involved in the progression of osteoarthritis (OA). Four OA cartilage-related microarray datasets were downloaded...