Melatonin promotes embryonic development by enhancing tryptophan metabolism and NAD + synthesis [0.03%]
褪黑素通过增强tryptophan代谢和NAD +合成促进胚胎发育
Guang Yang,Junnan Fang,Huihui Wang et al.
Guang Yang et al.
Background: The peri-implantation period (days 6-14) is a metabolic checkpoint for embryonic viability, yet melatonin's role in this phase remains unclear despite its known benefits for early embryogenesis. ...
Yuliia Haluza,Beate Gruhl,Anja Wagner et al.
Yuliia Haluza et al.
Background: Salamanders such as axolotls exhibit exceptional regenerative abilities and longevity. While many ectothermic species reproduce into old age, axolotls have been proposed to experience post-maturation fertility...
Chromosomal rearrangements and segmental deletions contribute to gene loss in squamates [0.03%]
染色体重组和片段缺失对鳞足动物基因丢失的贡献
Buddhabhushan Girish Salve,H Sonal,Nagarjun Vijay
Buddhabhushan Girish Salve
Background: Genomic rearrangements, including segmental deletions, duplications, translocations, and inversions of DNA segments, can contribute to gene losses, thereby reshaping genome architecture and potentially resulti...
Stretching inhibits tumor growth in MMTV-PYMT via a direct mechanical effect [0.03%]
拉伸通过直接机械作用抑制MMTV-PYMT小鼠肿瘤生长
Lisbeth Berrueta,Chandra Bhan,Yi He et al.
Lisbeth Berrueta et al.
Background: Tumor-associated architecture and emerging mechanical properties (forces, pressure, tension, stiffness) affect the growth and invasiveness of cancer cells. Collagen fibers aligned perpendicular to the boundari...
Deep capsule neural network for identifying anticancer peptides using sequence to image transformation-based local embedded features [0.03%]
基于序列到图像转换的局部嵌入特征的深度胶囊神经网络在识别抗肿瘤肽中的应用
Shahid Akbar,Ali Raza,Matee Ullah et al.
Shahid Akbar et al.
Background: Globally, cancer is a major health issue that poses a significant threat to human health. Traditional treatments and laboratory-based methods have been extensively employed to treat cancer-affected cells. Howe...
CMMSCL-DPI: cross-modal multi-structural contrastive learning for predicting drug-protein interactions [0.03%]
CMMSCL-DPI：跨模态多结构对比学习预测药物蛋白质相互作用
Xingyue Gu,Yue Yu,Junkai Liu et al.
Xingyue Gu et al.
Background: Predicting drug-protein interactions (DPI) is essential for effective and safe drug discovery. Although deep learning methods have been extensively applied to DPI prediction, effectively leveraging the multi-s...
Limin Qiu,Haodong Chen,Hui Chen et al.
Limin Qiu et al.
Background: The formation of the Han Chinese is deeply rooted in the Neolithic cultures of the Yellow River basin, particularly the pivotal Longshan cultural sphere which bridged prehistoric societies and early dynastic c...
Overexpression of Rtl1 via synonymous mutation silencing miRNA target site drives skeletal muscle hypertrophy and inflammation in mice [0.03%]
同义突变沉默Rtl1基因的miRNA靶位点引起过度表达并驱动小鼠骨骼肌肥大和炎症反应
Xianwei Song,Lizhu Niu,Xiaoxuan Fan et al.
Xianwei Song et al.
Background: The retrovirus-derived Rtl1 gene is integral to skeletal muscle development. However, the underlying mechanisms and functional roles of Rtl1 in skeletal muscle growth remain unclear. ...
Emergence of clustered synapses during the development of a nervous system [0.03%]
神经系统的发育过程中簇状突触的出现
Yuval Balshayi,Eduard Bokman,Alon Zaslaver
Yuval Balshayi
Background: Synaptic organization is central for proper transmission of neural information. Studies in invertebrates and mammalian cortices show that synapses are clustered along neurite extensions, an organization that p...
FUS and TDP-43 aggregation are uncoupled from toxicity in ageing yeast models [0.03%]
老年酵母模型中的FUS和TDP-43聚集与其毒性无关
Donovan W McDonald,Nikita Chugh,Rares Sava et al.
Donovan W McDonald et al.
Background: Protein aggregation is indicative of the loss of proteostasis associated with neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Proteins like Fused in...