Small Molecule Heterocycles: Design and Synthesis of Novel Fluorescent Benzothiazoles for Early Detection of Alzheimer's disease [0.03%]
小分子杂环化合物：设计合成新型苯并噻唑荧光探针用于阿尔茨海默症的早期诊断
G S M Sundaram,Vijay Sharma
G S M Sundaram
Diagnostic agents capable of imaging β-amyloid (Aβ) plaques at prodromal stages could provide noninvasive tools to assess plaque burden and assist in determining efficacy of disease-modifying therapeutic interventions in vivo. To accompli...
Walter S Won,Spencer Knapp
Walter S Won
A short synthetic route to β,d-arabinofuranosyl 1-C-sulfonic acid (7), a possible biomimetic for the arabinofuranosyl anomeric phosphate, is described. The furanosyl 1-C-sulfonate was prepared by buffered DMDO oxidation of an S-acetyl-1-th...
Christiane Chbib,Adam J Sobczak,Mukesh Mudgal et al.
Christiane Chbib et al.
4-C-Alkyl/aryl-S-ribosylhomocysteine (SRH) analogues were prepared by coupling of homocysteine with 4-substituted ribofuranose derivatives. The diastereoselective incorporation of the methyl substituent into the 4 position of the ribose rin...
Synthesis and characterization of Se-adenosyl-L-selenohomocysteine selenoxide [0.03%]
Se-腺苷-L-硒同型半胱氨酸的合成与表征
Richard I Duclos Jr,Dillon C Cleary,Kalli C Catcott et al.
Richard I Duclos Jr et al.
Selenium is an essential micronutrient in humans due to the important roles of the selenocysteine-containing selenoproteins. Organoselenium metabolites are generally found to be substrates for the biochemical pathways of their sulfur analog...
Photolabile Amphiphiles with Fluorogenic Thioxanthone-Dithiane Functionality: Synthesis and Photoinduced Fragmentation in Micelles [0.03%]
具有荧光噻唑酮-二硫化物功能的光分解两亲分子：合成及胶束中的光诱导解离
Roman N Ezhov,Vladimir V Rozhkov,Janaki R R Majjigapu et al.
Roman N Ezhov et al.
Novel photolabile amphiphiles containing thioxanthone-based fluorogenic caging groups are developed. Photoinduced fragmentation in dithiane-thioxanthone adducts was demonstrated to occur with 100% quantum efficiency at λ ~ 320 nm and more ...
Benjamin Rudshteyn,Alvaro Castillo,Alexander Greer
Benjamin Rudshteyn
A carbon-sulfur molecule has been designed as a mimic of peptides. Density functional theory calculations showed that the oxidation of 10 moles of methanedithiol led to a polydisulfide oligomer, HS(CH2SS)9CH2SH. The polydisulfide can adopt ...
Photooxidation of metal-bound thiolates: reactivity of sulfur containing peroxidic intermediates [0.03%]
金属结合硫醇盐的光氧化：含硫过氧中间体的反应性
Dong Zhang,Billy Hernandez,Matthias Selke
Dong Zhang
A variety of reactions of singlet oxygen with metal-bound thiolates are described, and contrasted with the photooxidation of organic sulfides. Superficially, these two processes appear to involve similar mechanisms, but there are important ...