Effectiveness of the recruitment strategies used in the Baby-Feed Online Trial, a trial to test an educational web application for caregivers to prevent excessive weight gain in infants [0.03%]
婴儿喂养在线试验的招募策略有效性研究：测试一种教育型网络应用程序以预防婴幼儿体重增加过多
Cristina Palacios,Alayne Gatto,Gabriella Reingevurts et al.
Cristina Palacios et al.
Background/aims: To analyze the effectiveness of recruitment methods in the Baby-Feed Online Trial. Methods: This randomized clinical t...
Adaptive versus fixed designs in confirmatory clinical trials: centering the choice on ethics [0.03%]
适应性设计与固定设计在确证性临床试验中的以太学为中心的选择问题
Stef Baas,Lukas Pin,David S Roberstoon et al.
Stef Baas et al.
Background: Because confirmatory clinical trials are costly, large-scale endeavors, the choice of their design carries significant weight. While the current methodological landscape offers tools to address residual pre-tr...
Rejoinder: "Adaptive versus fixed designs in confirmatory clinical trials: Centering the choice on ethics" [0.03%]
回应文章：“确证性临床试验中适应性设计与固定设计的选择：以伦理学为中心”
Stef Baas,Lukas Pin,David S Robertson et al.
Stef Baas et al.
Design and monitoring of randomized trials in vision research with binary endpoints [0.03%]
双眼视觉研究中以二分类指标为观察终点的随机试验的设计和监查
Guoqing Diao,Qiang Zhang,Toshimitsu Hamasaki et al.
Guoqing Diao et al.
Background: Randomized eye trials often involve both eyes if eligible from a patient. Few studies have investigated the design properties of randomized eye trials with binary endpoints, for instance, the sample size/power...
A statistical evaluation of decision-making methods and the efficiency of Bayesian multi-arm multi-stage trials [0.03%]
决策方法的统计评估及贝叶斯多元多阶段试验的效率分析
Abigail McGrory,Haolun Shi,Anna Heath
Abigail McGrory
Background/Aims: Multi-arm multi-stage trials benefit patients by providing a flexible and versatile clinical trial design compared with standard randomized controlled trials. Multi-arm multi-stage trials can evaluate multiple interventions...
Accounting for non-adherence: A re-analysis of the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results trial [0.03%]
考虑不依从性：利拉鲁肽疗效和作用在糖尿病：心血管结果试验的再分析
Kathrine Kold Sørensen,Johan Sebastian Ohlendorff,Anders Munch et al.
Kathrine Kold Sørensen et al.
Background/aims: The Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results trial randomized patients with diabetes to liraglutide or placebo. The per-protocol analysis conditioned on post...
Rami Hawila,Susan Halabi,Ruitao Lin et al.
Rami Hawila et al.
Background: In this article, we introduce a Phase I clinical trial design that utilizes late-onset toxicity outcomes to determine group-specific doses when groups are partially ordered before the trial. By "partially orde...
Trial informed consent forms, the Declaration of Helsinki and the SPIRIT 2025 statement [0.03%]
《赫尔辛基宣言》《SPIRIT 2025声明》与试验知情同意书
Rafael Dal-Ré,Arthur L Caplan
Rafael Dal-Ré