How is missing data handled in cluster randomized controlled trials? A review of trials published in the NIHR Journals Library 1997-2024 [0.03%]
集群随机对照试验中如何处理缺失数据？一项1997-2024年发表在NIHR期刊图书馆的试验回顾
Siqi Wu,Richard M Jacques,Stephen J Walters
Siqi Wu
Background: Cluster randomized controlled trials are increasingly used to evaluate the effectiveness of interventions in clinical and public health research. However, missing data in cluster randomized controlled trials c...
Estimating treatment effects in trials with outcome data truncated by death: A case study on aligning estimators with estimands [0.03%]
基于死亡截断的疗效估计：与研究估计目标相统一的统计分析方法——个例研究
Tra My Pham,Brennan C Kahan,Andre Lopes et al.
Tra My Pham et al.
Background/aims: Randomised clinical trials assessing treatment effects on health outcomes (e.g. quality of life) can be affected by data truncation by death, where some patients die before their outcome measure is assess...
Adjudication of cause of death in older adults: Learnings for death certification from the ASPirin in Reducing Events in the Elderly study [0.03%]
老年人死亡原因的判定：来自ASPREE研究对死亡证明书填写的启示
Mark R Nelson,John J McNeil,Nigel Stocks et al.
Mark R Nelson et al.
Background: Death certificates are a legal requirement for a body to be buried or cremated. Many randomised clinical trials utilise disease-specific causes of death as key outcomes informed by these documents. Determinati...
Scoping review of family caregiver roles in cancer clinical trial decision-making [0.03%]
癌症临床试验决策中家庭护理者角色的范围回顾性研究
Eric C Blackstone,Barbara J Daly,Mark P Aulisio et al.
Eric C Blackstone et al.
BackgroundCancer clinical trials are vital for improving treatments. Clinical trial decision-making has been examined from the perspectives of patients and oncologists, but caregiver perspectives on clinical trials and roles in patient enro...
Automated data collection from an electronic medical record for a prospective real-world study in patients with retinal disease (VOYAGER) [0.03%]
Clare Bailey,Ian Pearce,Christiana Dinah et al.
Clare Bailey et al.
Background/AimsVOYAGER is a prospective, real-world study of treatment patterns and outcomes in retinal diseases. Data collection often requires double entry of routinely captured clinical data, into both site electronic medical records and...
Evaluating re-identification risks scores in publicly available clinical trial datasets: Insights and implications [0.03%]
公开的临床试验数据集中的再识别风险评估：见解与影响
Aryelly Rodriguez,Linda J Williams,Stephanie C Lewis et al.
Aryelly Rodriguez et al.
BackgroundThe motivations to share anonymised datasets from clinical trials within the scientific community are increasing. Many anonymised datasets are now publicly available for secondary research. However, it is uncertain whether they po...
Incorporating data from multiple ongoing trials for Bayesian two-stage phase II single-arm studies [0.03%]
贝叶斯二期单阶段单臂临床试验的多重在研数据纳入方法研究
Susan Halabi,Taehwa Choi,Elizabeth Garrett-Mayer et al.
Susan Halabi et al.
Background/aim: Basket designs have been utilized in recent oncology clinical trials due to an increased interest in precision medicine. One current successful basket trial is the American Society for Clinical Oncology Ta...
A randomized study comparing patient portal and email communications for trial recruitment [0.03%]
一种针对患者门户和电子邮件通信的随机研究以招募受试者
Jeanette Y Ziegenfuss,Elanadora U Sour,Erica J Roelofs et al.
Jeanette Y Ziegenfuss et al.
BackgroundRecruitment is a necessary, yet challenging component to clinical trial implementation. Using intentional strategies to meet enrollment goals is important to ensure the recruited sample adequately reflects the intended study popul...
Sameer Parpia,Jacquelyn Dobinson,Anna Heath et al.
Sameer Parpia et al.
BackgroundThere is a critical shortage of biostatistics expertise and targeted training programs in clinical trials across Canada.MethodsThe Canadian Network for Statistical Training in Trials (CANSTAT), a pan-Canadian, multi-institutional ...
Policy recommendations for implementing registries to minimize over-volunteering in Phase I clinical trials [0.03%]
关于实施登记制度以减少一期临床试验中过度自愿的政策建议
Roberto Abadie,Jill A Fisher,Shadreck Mwale et al.
Roberto Abadie et al.
Thousands of healthy volunteers enroll in Phase I clinical trials annually, often motivated by financial gain. Some engage in "over-volunteering"-participating in multiple studies simultaneously or ignoring washout periods. While serious ad...