Fadi G Akar,Colleen E Clancy
Fadi G Akar
From Fifth Business to Protagonist: the complex roles of ion channel anchors in cardiac arrhythmia [0.03%]
从第五业务到主角：心律失常离子通道锚蛋白的复杂作用
Crystal F Kline,Peter J Mohler
Crystal F Kline
Proper regulation of cardiac ion channel activity is critical for cellular ion homeostasis and myocyte electrical activity. Recent work has demonstrated that cardiac ion channels are not isolated pores in plasmid membranes, but rather exist...
Engineering a biological pacemaker: in vivo, in vitro and in silico models [0.03%]
心脏起搏器的构建：体内、体外和计算机模型
Richard B Robinson
Richard B Robinson
Several hundred thousand electronic pacemakers are implanted in the US each year to treat abnormally slow heart rates. Biological pacemaker research strives to replace this hardware, and the associated monitoring and maintenance, by using g...
Using computational modeling to predict arrhythmogenesis and antiarrhythmic therapy [0.03%]
利用计算模型预测心律失常及抗心律失常治疗的效果
Jonathan D Moreno,Colleen E Clancy
Jonathan D Moreno
The use of computational modeling to predict arrhythmia and arrhythmogensis is a relatively new field, but has nonetheless dramatically enhanced our understanding of the physiological and pathophysiological mechanisms that lead to arrhythmi...
Integrative computational models of cardiac arrhythmias -- simulating the structurally realistic heart [0.03%]
心脏心律失常的集成计算模型——模拟结构真实的器官
Natalia A Trayanova,Brock M Tice
Natalia A Trayanova
Simulation of cardiac electrical function, and specifically, simulation aimed at understanding the mechanisms of cardiac rhythm disorders, represents an example of a successful integrative multiscale modeling approach, uncovering emergent b...
On habits and addiction: An associative analysis of compulsive drug seeking [0.03%]
有关习惯和瘾性的问题：对强迫性药物寻求行为的联想分析
Sean B Ostlund,Bernard W Balleine
Sean B Ostlund
The processes that underlie the pathological pursuit of drugs in addiction and that support the transition from casual drug taking to their compulsive pursuit have recently been proposed to reflect the interaction of two action control proc...
T L Van Belle,P Taylor,M G von Herrath
T L Van Belle
Our understanding of the genetics, aetiology and pathogenesis of Type 1 Diabetes (T1D) was propelled by the discovery of animal models of T1D in the late 1970s and early 1980s, particularly the non-obese diabetic (NOD) mouse. Since then, tr...
W Matthew Leevy,Nathan Serazin,Bradley D Smith
W Matthew Leevy
Over the last thirteen years, the field of optical imaging has expanded from in vitro fluorescence microscopy of cells to in vivo imaging of living animals. Recent advances in optical imaging of bacterial infection have been propelled by th...
Parsing the Addiction Phenomenon: Self-Administration Procedures Modeling Enhanced Motivation for Drug and Escalation of Drug Intake [0.03%]
从自我给药程序模型解析成瘾现象：增强动机与药物摄入量的增加
Erik B Oleson,David C S Roberts
Erik B Oleson
Investigators who study drug addiction are fortunate to have access to excellent animal models. Such models will be invaluable in the assessment of factors involved in the progression of drug addiction. The relevance of these findings, howe...