C Kaloff,K Anastassiadis,A Ayadi et al.
C Kaloff et al.
The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which h...
Cardiac tissue engineering using human stem cell-derived cardiomyocytes for disease modeling and drug discovery [0.03%]
基于人类干细胞分化的心肌细胞的 cardiac tissue engineering 在疾病建模和药物发现中的应用
Irene C Turnbull,Deborah K Lieu,Ronald A Li et al.
Irene C Turnbull et al.
Cardiovascular disease (CVD) is the most prevalent health problem in the world, and the high mortality rate associated with irreversibly injured heart muscle motivates an urgent need for the development of novel therapies to treat damaged m...
Epstein-Barr Virus Infection in the Development of Neurological Disorders [0.03%]
EB病毒感染与神经精神系统疾病发病的关系研究进展
Samantha S Soldan,Paul M Lieberman
Samantha S Soldan
Epstein-Barr Virus (EBV) is a ubiquitous human herpesvirus that contributes to the etiology of diverse human cancers and auto-immune diseases. EBV establishes a relatively benign, long-term latent infection in over 90 percent of the adult p...
Applying the 3Rs to non-human primate research: Barriers and solutions [0.03%]
推动非人灵长类研究中的“3R”原则：障碍及解决方案
Mark J Prescott,Jan A Langermans,Ian Ragan
Mark J Prescott
Progress is being made in the development and application of methods to replace, reduce and refine the use of non-human primates (NHPs) in biomedical research and testing of products and devices. However, there remain considerable cultural ...
In vitro models of HIV-1 infection of the Central Nervous System [0.03%]
体外人类免疫缺陷病毒(HIV-1)中枢神经系统感染模型
Celeste Faia,Karlie Plaisance-Bonstaff,Francesca Peruzzi
Celeste Faia
Neurocognitive disorders associated with HIV-1 infection affect more than half of persons living with HIV (PLWH) under retroviral therapy. Understanding the molecular mechanisms and the complex cellular network communication underlying neur...
Chediak-Higashi syndrome: a review of the past, present, and future [0.03%]
Chediak-Higashi综合征的研究回顾过去、现在和未来展望
Prashant Sharma,Elena-Raluca Nicoli,Jenny Serra-Vinardell et al.
Prashant Sharma et al.
Since the initial description of Chediak-Higashi syndrome (CHS), over 75 years ago, several studies have been conducted to underscore the role of the lysosomal trafficking regulator (LYST) gene in the pathogenesis of disease. CHS is a rare ...
Interactions between human microbiome, diet, enteric viruses and immune system: Novel insights from gnotobiotic pig research [0.03%]
人类微生物组、饮食、肠道病毒和免疫系统之间的相互作用：无菌猪研究的新见解
Anastasia N Vlasova,Gireesh Rajashekara,Linda J Saif
Anastasia N Vlasova
Studies over the past few decades demonstrated that gnotobiotic (Gn) pigs provide an unprecedented translational model to study human intestinal health and diseases. Due to the high degree of anatomical, physiological, metabolic, immunologi...
Matthew J Fogarty,Gary C Sieck
Matthew J Fogarty
Breathing is achieved without thought despite being controlled by a complex neural network. The diaphragm is the predominant muscle responsible for force/pressure generation during breathing, but it is also involved in other non-ventilatory...
Drosophila and its gut microbes: a model for drug-microbiome interactions [0.03%]
果蝇及其肠道微生物：药物-微生物组相互作用的模型系统
Angela E Douglas
Angela E Douglas
Drosophila is an excellent system to investigate how the presence and composition of the gut microbiome influences the efficacy of therapeutic drugs and downstream consequences for host health. These opportunities derive from two key attrib...
Model systems for the study of how symbiotic associations between animals and extracellular bacterial partners are established and maintained [0.03%]
研究动物与胞外细菌伙伴之间共生关联的建立和维持的模型系统
Eric J Koch,Margaret McFall-Ngai
Eric J Koch
This contribution describes the current state of experimental model development and use as a strategy for gaining insight into the form and function of certain types of host-microbe associations. Development of quality models for the study ...