Hongyan Dai,Ronald J Korthuis
Hongyan Dai
Mast cells are best known for their role in allergic reactions but are also now recognized for their important contributions to a number of disparate inflammatory conditions through the release of inflammatory mediators, serglycin and other...
Luis A Martinez-Lemus,Edgar Luis Galiñanes
Luis A Martinez-Lemus
Inward eutrophic remodeling is a common structural change found in small resistance arteries that has been associated with an increased risk for life threatening cardiovascular events, the number one cause of death in industrialized societi...
Angiogenesis and Proteinases: Influence on Vascular Morphogenesis, Stabilization and Regression [0.03%]
血管生成与蛋白酶：对血管形态发生、稳定和消退的影响
George E Davis
George E Davis
Proteinases play a key role during angiogenesis and have been implicated in vascular morphogenesis, stabilization and regression. Major advances have identified specific proteinases and their inhibitors that separately control these process...
Daniel J Buysse,Anne Germain,Martica Hall et al.
Daniel J Buysse et al.
Insomnia is a common clinical condition resulting in significant costs and morbidity. Previous models of insomnia focusing on psychological and behavioral processes are useful clinically, but lack neurobiological specificity. We propose an ...
Tumor-stroma: In vivo assays and intravital imaging to study cell migration and metastasis [0.03%]
肿瘤-基质：体内实验和在体成像技术用于研究细胞迁移和转移
Zhen Ni Zhou,Pamela J Boimel,Jeffrey E Segall
Zhen Ni Zhou
The development of metastatic disease is often correlated with poor patient outcome in a variety of different cancers. The metastatic cascade is a complex, multistep process that involves the growth of the primary tumor and angiogenesis, in...
THE AUTODIGESTION HYPOTHESIS AND RECEPTOR CLEAVAGE IN DIABETES AND HYPERTENSION [0.03%]
自消化假说及糖尿病和高血压中的受体切削
F A Delano,A Y Chen,K-I S Wu et al.
F A Delano et al.
One of the key features of cardiovascular complications, such as hypertension or diabetes, is that they often appear at the same time in the same individual together with other forms of co-morbidities. While clinically a recognized phenomen...
Protease Activity and the Role of the Endothelial Glycocalyx in Inflammation [0.03%]
蛋白酶活性与糖萼在炎症中的作用
Herbert H Lipowsky
Herbert H Lipowsky
A new paradigm for governance of leukocyte-endothelium (WBC-EC) adhesion during the inflammatory process is presented in which shedding of the endothelial glycocalyx exposes adhesion molecules on the EC surface, which promotes WBC-EC adhesi...
Marc Michael Zaruba,Loren J Field
Marc Michael Zaruba
Cardiomyocytes exhibit robust proliferative activity during development. After birth, cardiomyocyte proliferation is markedly reduced. Consequently, regenerative growth in the postnatal heart via cardiomyocyte proliferation (including, by i...
J Ashley Jefferson,Jeffrey W Pippin,Stuart J Shankland
J Ashley Jefferson
Membranous nephropathy (MN) is one of the commonest glomerular diseases, typically presenting in older males with nephrotic syndrome. The development and characterization of animal models of MN, in particular, the passive Heymann nephritis ...
Hai-Chun Yang,Yiqin Zuo,Agnes B Fogo
Hai-Chun Yang
Chronic kidney diseases result from recurrent or progressive injuries in glomeruli, tubules, interstitium and/or vasculature. In order to study pathogenesis, mechanisms and effects of interventions, many animal models have been developed, i...