Epigenetic Modulations of Induced Pluripotent Stem Cells: Novel Therapies and Disease Models [0.03%]
诱导多能干细胞的表观遗传调控：新疗法和疾病模型研究
Chengyang Huang,Joseph C Wu
Chengyang Huang
Recent breakthroughs in induced pluripotent stem cell (iPSC) technology hold promise for novel cell-based therapies as well as for effective drug development. The therapeutic potential of iPSCs makes it important to understand the reprogram...
Eun A Ko,Michael Y Song,Reshma Donthamsetty et al.
Eun A Ko et al.
Arterial vasoconstriction is an important physiological process in regulating blood pressure, and is involved in pathologies. The isolation of arteries from rats and mice, as well as the measurement of vascular tension in an ex vivo prepara...
Conducting the G-protein Coupled Receptor (GPCR) Signaling Symphony in Cardiovascular Diseases: New Therapeutic Approaches [0.03%]
心脏疾病中的G蛋白偶联受体信号传导交响乐：新的治疗策略
Stephen L Belmonte,Burns C Blaxall
Stephen L Belmonte
G protein-coupled receptors (GPCRs) are a virtually ubiquitous class of membrane-bound receptors, which functionally couple hormone or neurotransmitter signals to physiological responses. Dysregulation of GPCR signaling contributes to the p...
Jt McGuane,Kp Conrad
Jt McGuane
Preeclampsia is an important obstetric complication that arises in 5% of women after the 20(th) week of gestation, for which there is no specific therapy and no cure. Although much of the recent investigation in this field has focused on so...
Paulina Rampetsreiter,Emilio Casanova,Robert Eferl
Paulina Rampetsreiter
Tumor invasion and metastasis is a multi-step process that requires adaptation of cancer cells to conditions that they encounter during their journey to distant body sites. Understanding the molecular processes that underlie this adaptation...
Catherine T Nguyen,Qing Lu,Yibin Wang et al.
Catherine T Nguyen et al.
The Symptom Cluster of Sleep, Fatigue and Depressive Symptoms in Breast Cancer Patients: Severity of the Problem and Treatment Options [0.03%]
乳腺癌患者的睡眠、疲劳和抑郁症状群：问题的严重性和治疗选择
Lavinia Fiorentino,Michelle Rissling,Lianqi Liu et al.
Lavinia Fiorentino et al.
Breast cancer is the most commonly diagnosed cancer in women. Insomnia is a significant problem in breast cancer patients, affecting between 20% to 70% of newly diagnosed or recently treated cancer patients. Pain, fatigue, anxiety, and depr...
A Model for Studying Neuropsychological Effects of Sleep Intervention: The Effect of 3-week Continuous Positive Airway Pressure Treatment [0.03%]
一项研究睡眠干预措施的神经心理效应模型的研究：连续三周正压通气治疗的效应
In-Soo Lee,Wayne A Bardwell,Rujvi Kamat et al.
In-Soo Lee et al.
PURPOSE: Patients with obstructive sleep apnea (OSA) commonly have cognitive complaints. There are few randomized studies that have examined neuropsychological effects of continuous positive airway pressure (CPAP) treatment in patients with...
Jessica A Jiménez,Barry H Greenberg,Paul J Mills
Jessica A Jiménez
Heart failure (HF) patients have a high prevalence of disturbed sleep. Optimal pharmacological management of HF includes the use of angiotensin converting enzyme inhibitors and β-blockers, which have been associated with decreased severity...
Michael G Ziegler,Milos Milic,Hamzeh Elayan
Michael G Ziegler
The majority of patients with obstructive sleep apnea (OSA) suffer from hypertension as a complication of both the metabolic syndrome and OSA. In animal studies, intermittent hypoxia that simulates changes seen in OSA leads to chemoreceptor...