Intrauterine Growth Retardation - A Developmental Model of Type 2 Diabetes [0.03%]
宫内生长迟缓-2型糖尿病的发展模型
Sara E Pinney
Sara E Pinney
Intrauterine growth retardation has been linked to the development of type 2 diabetes later in life and the mechanisms underlying this phenomena are unknown. Epidemiological studies in humans show a distinct link with the exposure to an int...
Computational modeling helps uncover mechanisms related to the progression of emphysema [0.03%]
计算模型有助于揭示小肺气肿进展的机制
Béla Suki,Harikrishnan Parameswaran
Béla Suki
Emphysema is a progressive disease characterized by deterioration of alveolar structure and decline in lung function. While morphometric and molecular biology studies have not fully uncovered the underlying mechanisms, they have produced da...
Nicola Lai,L Bruce Gladden,Pierre G Carlier et al.
Nicola Lai et al.
How does skeletal muscle manage to regulate the pathways of ATP synthesis during large-scale changes in work rate while maintaining metabolic homeostasis remains unknown. The classic model of metabolic regulation during muscle contraction s...
Changing the Scale and Efficiency of Chemical Warfare Countermeasure Discovery Using the Zebrafish [0.03%]
利用斑马鱼改变化学战对策发现的规模和效率
Randall T Peterson,Calum A Macrae
Randall T Peterson
As the scope of potential chemical warfare agents grows rapidly and as the diversity of potential threat scenarios expands with non-state actors, so a need for innovative approaches to countermeasure development has emerged. In the last few...
Jessica P Otis,Steven A Farber
Jessica P Otis
Challenges in imaging lipid-processing events in live, intact vertebrate models have historically led to reliance on cultured cell studies, thus hampering our understanding of lipid metabolism and gastrointestinal physiology. Fluorescently-...
Ch Williams,Cc Hong
Ch Williams
For the chemical biologist, the promise of the post-genomic era has yet to be fulfilled. In the past decade, a flurry of phenotype-based chemical genetic screens in in vivo and cultured cell models have yielded numerous small molecules with...
Robert Esterberg,Allison B Coffin,Henry Ou et al.
Robert Esterberg et al.
The majority of hearing loss is caused by the permanent loss of inner ear hair cells. The identification of drugs that modulate the susceptibility to hair cell loss or spur their regeneration is often hampered by the difficulties of assayin...
When host defense goes awry: Modeling sepsis-induced immunosuppression [0.03%]
当宿主防御功能异常时：模拟脓毒症诱导的免疫抑制
Scott B Hu,Alexander Zider,Jane C Deng
Scott B Hu
Sepsis is associated with an initial hyperinflammatory state; however, therapeutic trials targeting the inflammatory response have yielded disappointing results. It is now appreciated that septic patients often undergo a period of relative ...
J Travis Hinson,Kenta Nakamura,Sean M Wu
J Travis Hinson
The study of complex disease genetics by genome-wide association studies (GWAS) has led to hundreds of genomic loci associated with disease traits in humans. However, the functional consequences of most loci are largely undefined. We discus...
Human ESC/iPSC-based "Omics" and Bioinformatics for Translational Research [0.03%]
基于人胚胎干细胞/诱导多能干细胞的“组学”和生物信息学的转化研究
Gerd Müller,Kirill V Tarasov,Rebekah L Gundry et al.
Gerd Müller et al.
The establishment of human embryonic stem cell lines (hESCs) created the basis for new approaches in regenerative medicine and drug discovery. Despite the potential of hESCs for cell based therapies, ethical controversies limit their use. T...