Andrew J Rennekamp,Randall T Peterson
Andrew J Rennekamp
Small molecules screens conducted with living zebrafish have become a commonly practiced technique for small molecule discovery. Embryonic and larval zebrafish exhibit an almost limitless range of phenotypes, from the cellular to the organi...
Beom Jin Lim,Hai-Chun Yang,Agnes B Fogo
Beom Jin Lim
Current medical therapies may delay chronic kidney disease progression. However, increasing experimental evidence indicates remission or even regression can be achieved. In order to study mechanisms progression vs. regression by different i...
Lupus Nephritis: Animal Modeling of a Complex Disease Syndrome Pathology [0.03%]
狼疮性肾炎的小动物模型及发病机制研究进展
Tracy L McGaha,Michael P Madaio
Tracy L McGaha
Nephritis as a result of autoimmunity is a common morbidity associated with Systemic Lupus Erythematosus (SLE). There is substantial clinical and industry interest in medicinal intervention in the SLE nephritic process; however, clinical tr...
Hitoshi Suzuki,Yusuke Suzuki,Jan Novak et al.
Hitoshi Suzuki et al.
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis in the world. IgAN is characterized by the mesangial accumulation of immune complexes containing IgA1, usually with co-deposits of complement C3 and variable IgG a...
Micromanaging microRNAs: using murine models to study microRNAs in lung fibrosis [0.03%]
利用小鼠模型研究microRNA在肺纤维化中的作用
Christian L Lino Cardenas,Naftali Kaminski,Daniel J Kass
Christian L Lino Cardenas
MicroRNAs are implicated in many biological and pathological processes and are emerging as key actors in lung health and disease. Specific patterns of dysregulated microRNAs have been found in idiopathic pulmonary fibrosis (IPF), an untreat...
Lama Noureddine,Sachin Hajarnis,Vishal Patel
Lama Noureddine
Polycystic kidney disease (PKD), the most common genetic cause of chronic renal failure, is characterized by the presence of numerous fluid-filled cysts in renal parenchyma. Despite recent progress, no FDA-approved therapy is available to r...
Akiko Maeda,Krzysztof Palczewski
Akiko Maeda
Continuous generation of visual chromophore through the visual (retinoid) cycle is essential to maintain eyesight and retinal heath. Impairments in this cycle and related pathways adversely affect vision. In this review, we summarize the ch...
MicroRNAs are potential therapeutic targets in fibrosing kidney disease: lessons from animal models [0.03%]
动物模型教会我们微小核糖核酸可能是纤维化肾脏疾病潜在的治疗靶点
Jeremy S Duffield,Monica Grafals,Didier Portilla
Jeremy S Duffield
Chronic disease of the kidneys has reached epidemic proportions in industrialized nations. New therapies are urgently sought. Using a combination of animal models of kidney disease and human biopsy samples, a pattern of dysregulated microRN...
Metalloproteinases: key and common mediators of multiple GPCRs and candidate therapeutic targets in models of hypertensive cardiac disease [0.03%]
金属蛋白酶：多种G蛋白偶联受体的关键和共同介体以及高血压心脏病模型中的候选治疗靶点
Xiang Wang,Ana-Maria Bosonea,Carlos Fernandez-Patron
Xiang Wang
Hypertensive cardiac disease remains a major cause of death worldwide because its typically complex etiology renders current treatments ineffective. Primary causative factors include environmental stressors, genetic predisposition and metab...
Metalloproteinases in hypertension and cardiac disease: differential expression and mutual regulation [0.03%]
高血压和心脏病中的金属蛋白酶：不同表达及相互调控
Ana-Maria Bosonea,Xiang Wang,Jeffrey Odenbach et al.
Ana-Maria Bosonea et al.
Arterial hypertension, a condition characterized by sustained elevated blood pressure, is associated with pathological cardiac remodeling (i.e. cardiac hypertrophy and fibrosis) and is a major risk factor for cardiac failure. These processe...