D Chandran,W B Copeland,S C Sleight et al.
D Chandran et al.
Synthetic biology is an engineering discipline that builds on our mechanistic understanding of molecular biology to program microbes to carry out new functions. Such predictable manipulation of a cell requires modeling and experimental tech...
In silico models of M. tuberculosis infection provide a route to new therapies [0.03%]
结核分枝杆菌感染的计算机模型为新的治疗方法提供了一条途径
Jennifer J Linderman,Denise E Kirschner
Jennifer J Linderman
Tuberculosis (TB) is a global health problem responsible for ~2 million deaths per year. Current antibiotic treatments are lengthy and fraught with compliance and resistance issues. There is a crucial need for additional approaches to provi...
Computational Models of Ventilator Induced Lung Injury and Surfactant Dysfunction [0.03%]
机械通气所致肺损伤和表面活性物质功能障碍的计算模型
Jason H T Bates,Bradford J Smith,Gilman B Allen
Jason H T Bates
Managing acute respiratory distress syndrome (ARDS) invariably involves the administration of mechanical ventilation, the challenge being to avoid the iatrogenic sequellum known as ventilator-induced lung injury (VILI). Devising individuali...
Nic Smith,Natalia Trayanova
Nic Smith
Geoffrey Clapp,Doron Levy
Geoffrey Clapp
Recently, there has been significant activity in the mathematical community, aimed at developing quantitative tools for studying leukemia and lymphoma. Mathematical models have been applied to evaluate existing therapies and to suggest nove...
Volatile Anesthetics and the Treatment of Severe Bronchospasm: A Concept of Targeted Delivery [0.03%]
吸入麻醉药与重度支气管痉挛的治疗：靶控输注的概念
Jarred R Mondoñedo,John S McNeil,Samir D Amin et al.
Jarred R Mondoñedo et al.
Status asthmaticus (SA) is a severe, refractory form of asthma that can result in rapid respiratory deterioration and death. Treatment of SA with inhaled anesthetics is a potentially life-saving therapy, but remarkably few data are availabl...
Phenotype, endotype and patient-specific computational modelling for optimal treatment design in asthma [0.03%]
哮喘的表型、内型和个体化计算模型指导的最佳治疗设计
Graham M Donovan,Merryn H Tawhai
Graham M Donovan
Understanding and treatment of asthma is significantly complicated by the heterogeneous spectrum of phenotypes associated with the disease. Recent advances in phenotype classification promise more targeted therapies, but these categories ar...
Tilo Winkler,Jose G Venegas,R Scott Harris
Tilo Winkler
Airway narrowing by smooth muscle constriction is a hallmark of asthma attacks that may cause severe difficulties of breathing. However, the causes of asthma and the underlying mechanisms are not fully understood. Bronchoconstriction within...
Pau Medrano-Gracia,Brett R Cowan,Avan Suinesiaputra et al.
Pau Medrano-Gracia et al.
Heart shape and function are major determinants of disease severity and predictors of future morbidity and mortality. Many studies now rely on non-invasive cardiac imaging techniques to quantify structural and functional changes. Statistica...
Vladimir Yarov-Yarovoy,Toby W Allen,Colleen E Clancy
Vladimir Yarov-Yarovoy
A wealth of experimental data exists describing the elementary building blocks of complex physiological systems. However, it is increasingly apparent in the biomedical sciences that mechanisms of biological function cannot be observed or re...