Influence of microbiome and diet on immune responses in food allergy models [0.03%]
微生物组和饮食对食物过敏模型中免疫反应的影响
Weronika Barcik,Eva Untersmayr,Isabella Pali-Schöll et al.
Weronika Barcik et al.
The intestinal immune system is intimately connected with the vast array of microbes present within the gut and the diversity of food components that are consumed daily. The discovery of novel molecular mechanisms, which mediate host-microb...
Melissa F Brereton,Frances M Ashcroft
Melissa F Brereton
ATP-sensitive K+ (KATP) channels in pancreatic β-cells couple glucose metabolism to insulin secretion. Reduced KATP channel activity produces excessive insulin release and hyperinsulinism whereas increased KATP channel activity leads to lo...
Engineered human pluripotent stem cell-derived cardiac cells and tissues for electrophysiological studies [0.03%]
用于电生理研究的工程化人多能干细胞源性心脏细胞和组织
Deborah K Lieu,Irene C Turnbull,Kevin D Costa et al.
Deborah K Lieu et al.
Human cardiomyocytes (CMs) do not proliferate in culture and are difficult to obtain for practical reasons. As such, our understanding of the mechanisms that underlie the physiological and pathophysiological development of the human heart i...
Reverse Engineering the Inflammatory "Clock": From Computational Modeling to Rational Resetting [0.03%]
炎症“钟”的逆向工程：从计算建模到理性重置
Yoram Vodovotz
Yoram Vodovotz
Properly-regulated inflammation is central to homeostasis. Traumatic injury, hemorrhagic shock, septic shock, and other injury-related processes such as wound healing are associated with dysregulated inflammation. Like many biological proce...
Shane Lee,Wael F Asaad,Stephanie R Jones
Shane Lee
Essential tremor (ET) is a neurological disorder of unknown etiology that is typically characterized by an involuntary periodic movement of the upper limbs. No longer considered monosymptomatic, ET patients often have additional motor and e...
William W Lytton
William W Lytton
Analysis of the brain as a dynamical system can assist drug development for dynamical diseases such as epilepsy. The pathological trajectories that make up a seizure differ significantly from the physiological trajectories of normal brain f...
Samuel A Neymotin,Salvador Dura-Bernal,Herman Moreno et al.
Samuel A Neymotin et al.
Dystonia is a movement disorder that produces involuntary muscle contractions. Current pharmacological treatments are of limited efficacy. Dystonia, like epilepsy is a disorder involving excessive activty of motor areas including motor cort...
Capturing intracellular Ca2+ dynamics in computational models of neurodegenerative diseases [0.03%]
计算模型在神经退行性疾病细胞内钙动态研究中的应用
Haroon Anwar
Haroon Anwar
Many signaling pathways crucial for homeostatic regulation, synaptic plasticity, apoptosis and immune response depend on Ca2+. Ca2+ dysregulation disrupts normal function of neurons and neuronal networks. This causes severe motor and cognit...
Modeling cytokine regulatory network dynamics driving neuroinflammation in central nervous system disorders [0.03%]
中枢神经系统疾病驱动神经炎症的细胞因子调控网络动力学建模
Warren D Anderson,Rajanikanth Vadigepalli
Warren D Anderson
A central goal of pharmacological efforts to treat central nervous system (CNS) diseases is to develop systemic therapeutics that can restore CNS homeostasis. Achieving this goal requires a fundamental understanding of CNS function within t...
Adam J H Newton,William W Lytton
Adam J H Newton
The occlusion of a blood vessel in the brain causes an ischemic stroke. Current treatment relies restoration of blood flow within 3 hours. Substantial research has focused on neuroprotection to spare compromised neural tissue and extend the...