Using the natural variation of mouse populations to understand host-gut microbiome interactions [0.03%]
利用小鼠群体的自然变异来解析宿主-肠道微生物群间的相互作用
Elin Org,Aldons J Lusis
Elin Org
One approach to understanding gut microbiome-host interactions, described in this review, is to examine how natural variation in a model organism, where environmental factors can be controlled, affects the microbiome and, in turn, how the m...
Donatella Donati
Donatella Donati
The etiology and pathogenesis of MS is likely to involve multiple factors interacting with each other, and the role of infectious and viral agents is still under debate, however a consistent amount of studies suggests that some viruses are ...
Rabbit models of heart disease [0.03%]
兔心肌病模型
Steven M Pogwizd,Donald M Bers
Steven M Pogwizd
Human heart disease is a major cause of death and disability. A variety of animal models of cardiac disease have been developed to better understand the etiology, cellular and molecular mechanisms of cardiac dysfunction and novel therapeuti...
Lida Mohtasham,Alexander Auais,Giovanni Piedimonte
Lida Mohtasham
The wide array of models available for the study of respiratory viral infections is extremely valuable for the development of novel therapeutic and prophylactic options against these highly prevalent diseases. In addition, through these mod...
Lena Böhnke,Larissa Traxler,Joseph R Herdy et al.
Lena Böhnke et al.
With the advancing age of humans and with it, growing numbers of age-related diseases, aging has become a major focus in recent research. The lack of fitting aging models, especially in neurological diseases where access to human brain samp...
Multi-scale biological and physical modelling of the tumour micro-environment [0.03%]
肿瘤微环境的多尺度生物物理模型化研究
Robert F Kunz,Byron J Gaskin,Qunhua Li et al.
Robert F Kunz et al.
Paced by advances in high performance computing, and algorithms for multi-physics and multi-scale simulation, a number of groups have recently established numerical models of flowing blood systems, where cell-scale interactions are explicit...
Arash Kheradvar,Ramin Zareian,Shimako Kawauchi et al.
Arash Kheradvar et al.
Valvular heart disease is the third-most common cause of heart problems in the United States. Malfunction of the valves can be acquired or congenital and each may lead either to stenosis or regurgitation, or even both in some cases. Heart v...
Animal models of cardiovascular disease as test beds of bioengineered vascular grafts [0.03%]
心血管疾病动物模型作为生物工程血管移植物测试平台
Sindhu Row,Daniel D Swartz,Stelios T Andreadis
Sindhu Row
The last two decades have seen many advances in regenerative medicine, including the development of tissue engineered vessels (TEVs) for replacement of damaged or diseased arteries or veins. Biomaterials from natural sources as well as synt...
In Vitro and In Vivo Models for Assessing the Host Response to Biomaterials [0.03%]
体外和体内评估生物材料宿主反应的方法模型研究进展
Leila S Saleh,Stephanie J Bryant
Leila S Saleh
The foreign body response (FBR) occurs ubiquitously to essentially all non-biological materials that are implanted into higher organisms. The FBR is characterized by inflammation followed by fibrosis and is mediated largely by macrophages. ...