In silico modeling of interstitial lung mechanics: implications for disease development and repair [0.03%]
计算机模拟间质性肺力学：对疾病发展和修复的影响
Béla Suki,Arnab Majumdar,Matthew A Nugent et al.
Béla Suki et al.
In this perspective, we first review some of the published literature on structural modeling of the mechanical properties of the lung parenchyma. Based on a recent study, we demonstrate why mechanical dysfunction accompanying parenchymal di...
The role of Na dysregulation in cardiac disease and how it impacts electrophysiology [0.03%]
钠离子紊乱在心脏疾病中的作用及其对心电生理的影响
Brian O&#x;Rourke,Christoph Maack
Brian O&#x;Rourke
Ca(2+) is well known as the central player in cardiac cell physiology, mediating Ca(2+) activation of myosin ATPase and contraction, the stimulation of Ca(2+)-activated signaling pathways and modulation of mitochondrial energy production. A...
Weiqin Lu,Marcia A Ogasawara,Peng Huang
Weiqin Lu
Increased generation of reactive oxygen species (ROS) has been observed in cancer, degenerative diseases, and other pathological conditions. ROS can stimulate cell proliferation, promote genetic instability, and induce adaptive responses th...
Mouse Models of Lipodystrophy Key reagents for the understanding of the metabolic syndrome [0.03%]
可用于理解代谢综合征的脂代谢障碍小鼠模型及关键试剂
Ingrid Wernstedt Asterholm,Nils Halberg,Philipp E Scherer
Ingrid Wernstedt Asterholm
Both the disproportionate loss of adipose tissue in the case of lipodystrophies and the disproportionate gain of adipose tissue in obesity are frequently associated with an increase in insulin resistance and its complications. Leptin replac...
Dennis A Bente,Rebeca Rico-Hesse
Dennis A Bente
The need for models of dengue disease has reached a pinnacle as the transmission of this mosquito-borne virus has increased dramatically. Little is known about the mechanisms that lead to dengue fever and its more severe form, dengue hemorr...