Steven C George
Steven C George
Genetically encoded fluorescent sensors for studying healthy and diseased nervous systems [0.03%]
基因编码的荧光传感器在研究健康和患病神经系统中的应用
Lin Tian,Loren L Looger
Lin Tian
Neurons and glia are functionally organized into circuits and higher-order structures via synaptic connectivity, well-orchestrated molecular signaling, and activity-dependent refinement. Such organization allows the precise information proc...
Monica J Carson,Janelle Crane,Alison X Xie
Monica J Carson
The mammalian central nervous system (CNS) is populated very early in development by tissue macrophages referred to as microglia. By adulthood, this CNS-resident population is found in all regions of the brain and spinal cord. Despite nearl...
Reno C Reyes,Vladimir Parpura
Reno C Reyes
Neurons have been the focus of neuroscience research. Only recently, however, astrocytes, a subset of glial cells, have been on the neurobiology "radar" owing to their Ca(2+) excitability, which allows them to signal to other astrocytes and...
Sanja Sale,Sandra Orsulic
Sanja Sale
Mice have mainly been used in ovarian cancer research as immunodeficient hosts for cell lines derived from the primary tumors and ascites of ovarian cancer patients. These xenograft models have provided a valuable system for pre-clinical tr...
Maxim Bazhenov,Igor Timofeev,Flavio Fröhlich et al.
Maxim Bazhenov et al.
Epileptic seizures constitute a complex multiscale phenomenon that is characterized by synchronized hyperexcitation of neurons in neuronal networks. Recent progress in understanding pathological seizure dynamics provides crucial insights in...
Modeling cancer patient populations in mice: complex genetic and environmental factors [0.03%]
利用小鼠建模癌症患者群体：复杂的遗传和环境因素
Daniel R Radiloff,Erica S Rinella,David W Threadgill
Daniel R Radiloff
Genetic differences among individuals contribute to differential susceptibility to cancer and, undoubtedly, to variable efficacy and toxicity of pharmacological-based therapeutics. Many of the specific molecular processes involved in human ...
Robert J Major,Kenneth D Poss
Robert J Major
Heart disease remains the leading cause of mortality throughout the world. Mammals have an extremely limited capacity to repair lost or damaged heart tissue, thus encouraging biologists to seek out models for heart regeneration. Zebrafish e...
Richard D Patten
Richard D Patten
Clinical observations made over several decades support the existence of gender differences in cardiovascular disease prevalence and severity. For example, women exhibit a delay in the onset of vascular disease compared to men and the tempo...
Ben Fabry,Jeffrey J Fredberg
Ben Fabry
Excessive force generation by airway smooth muscle is the main culprit in excessive airway narrowing during an asthma attack. The maximum force the airway smooth muscle can generate is exquisitely sensitive to muscle length fluctuations dur...