Ingo Muegge,Scott Oloff
Ingo Muegge
Although the term virtual screening as the in silico analog of high throughput screening has been coined only a decade ago, virtual screening is now a widespread lead identification method in the pharmaceutical industry. A myriad of differe...
Dan C Fara,Tudor I Oprea,Eric R Prossnitz et al.
Dan C Fara et al.
High-throughput screening (HTS) represents the dominant technique for the identification of new lead compounds in current drug discovery. It consists of physical screening (PS) of large libraries of chemicals against one or more specific bi...
A technical overview of supercritical fluid chromatography-mass spectrometry (SFC-MS) and its recent applications in pharmaceutical research and development [0.03%]
超临界流体色谱-质谱(SFC-MS)技术及其在药物研发中的应用综述
Liuxi Chen,Brian Dean,Xiaorong Liang
Liuxi Chen
In this paper, we review the growing development and applications of supercritical fluid chromatography-mass spectrometry (SFC-MS) for the analysis of small molecular analytes and biomarkers in drug discovery. As an alternative chromatograp...
Mass spectrometry based approaches and strategies in bioanalysis for qualitative and quantitative analysis of pharmaceutically relevant molecules [0.03%]
基于质谱的生物分析方法和策略，用于药学相关分子的定性和定量分析
Frank Klont,Gérard Hopfgartner
Frank Klont
Mass spectrometry plays an essential role in qualitative and quantitative analysis of pharmaceutically relevant molecules. The present review summarizes some the most common applications of LC-MS for the characterization of therapeutic low-...
Drug discovery from natural products using affinity selection-mass spectrometry [0.03%]
亲和选择-质谱技术在天然产物药物发现中的应用
Ruth N Muchiri,Richard B van Breemen
Ruth N Muchiri
As a starting point for drug discovery, affinity selection-mass spectrometry (AS-MS) is ideal for the discovery of lead compounds from chemically diverse sources such as botanical, fungal and microbial extracts. Based on binding interaction...
Maarten Honing
Maarten Honing
Moira Rachman,Serena Piticchio,Maciej Majewski et al.
Moira Rachman et al.
Fragment-based drug discovery (FBDD) emerged as a disruptive technology and became established during the last two decades. Its rationality and low entry costs make it appealing, and the numerous examples of approved drugs discovered throug...
Iwan J P De Esch
Iwan J P De Esch
Lorena Zara,Nina-Louisa Efrém,Jacqueline E van Muijlwijk-Koezen et al.
Lorena Zara et al.
One of the remaining bottlenecks in fragment-based drug design (FBDD) is the initial exploration and optimization of the identified hit fragments. There is a growing interest in computational approaches that can guide these efforts by predi...
David Domonkos,Kalman Könczöl,Imre Török
David Domonkos
This review provides an overview of the various theoretical and practical aspects of biotech plant design. It covers engineering, quality, regulatory, safety, environmental and economical points to be considered. Current knowledge and futur...