Cortisol suppression impairs retrieval of emotional memory and changes its neural correlates immediately and four days post-treatment [0.03%]
皮质醇抑制损害情绪记忆的提取并在治疗后立即和四天内改变其神经相关性
Despina Antypa,Patrik Vuilleumier,Ulrike Rimmele
Despina Antypa
Emotional memories are hard to forget. Yet, past research showed that very high and very low levels of the stress hormone cortisol crucially affect the retrieval of emotional memories both immediately and in a long-lasting manner. With a do...
Synthetic cooling agents enhance nicotine reinforcement and mesolimbic dopamine signaling [0.03%]
合成冷却剂增强尼古丁的强化作用和中脑边缘多巴胺信号传导
Sarah K Maddox,Esther N Mensah,Lauren E Young et al.
Sarah K Maddox et al.
Flavor additives in electronic delivery systems (ENDS) have been shown to enhance nicotine reinforcement. Although some states and cities have pursued implementation of menthol bans, synthetic coolants such as WS-3 and WS-23 have emerged as...
Cool but not harmless: synthetic cooling agents enhance nicotine reinforcement via the mesolimbic dopamine system [0.03%]
凉剂但不无害：合成凉剂通过中脑多巴胺系统增强尼古丁的奖赏效应
Mary Amir Bishara,Giordano de Guglielmo
Mary Amir Bishara
Restoring prefrontal function with dopaminergic enhancement of memory updating in addiction [0.03%]
通过多巴胺增强成瘾的记忆更新来恢复前额叶功能
Ahmet O Ceceli,Rita Z Goldstein
Ahmet O Ceceli
Evidence for pro-cognitive benefits of cannabinoids in people with bipolar disorder [0.03%]
cannabinoid类大麻素物质的认知作用优势效应在双相情感障碍患者中的证据
Alannah Miranda,Breanna M Holloway,Elizabeth Peek et al.
Alannah Miranda et al.
Cannabis use is highly prevalent among people with bipolar disorder, potentially due to a desire to self-medicate against symptoms, such as racing thoughts and poor concentration. Such symptoms are associated with attention and inhibitory c...
Ketamine-induced analgesia and dissociation show distinct behavioral and neural correlates [0.03%]
氯胺酮致痛觉缺失和分离的发生具有不同的行为学及神经机制
Noam Goldway,Itamar Jalon,Yara Agbaria et al.
Noam Goldway et al.
Ketamine produces both analgesic and dissociative effects, but whether analgesia depends on dissociation remains debated. This question is part of a broader discussion on whether the subjective experiences elicited by psychoactive drugs are...
Psilocybin produces amplified acute responses and sex-specific long-term increases in sensorimotor gating in the mGlu5 knockout mouse model of schizophrenia [0.03%]
裸头素可增强拟两性霉素受体敲除小鼠模型的急性反应，并增加雄性小鼠的长期感觉门控能力
James J Gattuso,Ahmed Kamal,Jennyfer M Payet et al.
James J Gattuso et al.
Psilocybin is a serotonergic psychedelic drug with emerging therapeutic applications, yet its actions under glutamatergic dysfunction, and relevance to schizophrenia and associated psychiatric disorders, remain unclear. We examined the acut...
Dose-related reductions in prefrontal recruitment during cognitive reappraisal following oral delta-9-tetrahydrocannabinol in posttraumatic stress disorder [0.03%]
口服δ-9四氢大麻酚对创伤后应激障碍认知再评价过程中前额叶募集的剂量依赖性降低作用
Connor J Haggarty,Christine A Rabinak
Connor J Haggarty
Posttraumatic stress disorder (PTSD) is characterized by difficulties in emotion regulation and altered recruitment of prefrontal control systems during cognitive reappraisal. Cannabinoid signaling has been implicated in stress and affect r...
Developmental trajectories of mitochondrial function linking early-life stress to later-life brain vulnerability [0.03%]
早期压力通过线粒体功能发展轨迹影响晚年大脑脆弱性的作用机制研究
Thamyris Santos-Silva,Felipe V Gomes
Thamyris Santos-Silva
Acute alcohol triggers rank-specific social ascent through a prefrontal-accumbens circuit in male mice [0.03%]
急性酒精通过前额叶-伏隔核环路在雄性小鼠中触发等级特异性社会地位上升
Xiao Jia,Hui Zhou,Can Tang et al.
Xiao Jia et al.
Alcohol is known to alter social behavior, yet how it acts on the brain to produce specific, rank-dependent changes in social competition remains unknown. Here we show in male mice that a low dose of alcohol induces a rapid, transient, and ...