Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases [0.03%]
干扰代谢物化学物质对脂肪肝疾病进展的危害影响概述
Garam An,Jisoo Song,Wei Ying et al.
Garam An et al.
Background: Given the global increase in obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) is a major health concern. Because the liver is the primary organ for xenobiotic metabolism, the impact of...
CircSLCO3A1 depletion ameliorates lipopolysaccharide-induced inflammation and apoptosis of human pulmonary alveolar epithelial cells through the miR-424-5p/HMGB3 pathway [0.03%]
circslco3a1通过miR-424-5p/hmgb3信号通路缓解脂多糖诱导的人肺泡上皮细胞炎症和凋亡
Yan Li,Chunmei Zhang,Zhongyan Zhao
Yan Li
Background: Recent studies have shown the pathogenesis of acute lung injury (ALI) involves circular RNA (circRNA). However, there are no data on the role of circSLCO3A1 in ALI and the underlying mechanism. ...
No association of prion protein gene (PRNP) polymorphisms with susceptibility to the pandemic 2009 swine flu [0.03%]
朊蛋白基因（PRNP）多态性与对大流行性2009年猪流感的易感性的关联性研究
Yong-Chan Kim,Sae-Young Won,Byung-Hoon Jeong
Yong-Chan Kim
Background: The pandemic 2009 swine flu is a highly infectious respiratory disorder caused by H1N1 influenza A viruses. A recent study reported that knockout of the prion protein gene (PRNP) induced susceptibility and let...
Physical and biomimetic treatment methods to reduce microplastic waste accumulation [0.03%]
物理和仿生处理方法减少微塑料废物积累的问题
Hyesoo Lee,Joo Eun Shim,In Hae Park et al.
Hyesoo Lee et al.
Background: Since the Covid-19 pandemic in 2019, the use of plastics has increased exponentially, so it is imperative to manage and dispose of these plastic wastes safely. ...
Sang Young Kim,Jin-Pyo Lee,Woo-Ri Shin et al.
Sang Young Kim et al.
Background: A significant heart attack known as a myocardial infarction (MI) occurs when the blood supply to the heart is suddenly interrupted, harming the heart muscles due to a lack of oxygen. The incidence of myocardia...
Intestine epithelial cell-derived extracellular vesicles alleviate inflammation induced by Clostridioides difficile TcdB through the activity of TGF-β1 [0.03%]
肠上皮细胞源性外泌体通过活化TGF-β1缓解难辨梭菌TcdB诱导的炎症反应
Shuangshuang Wan,Guangzhong Song,Hui Hu et al.
Shuangshuang Wan et al.
Background: Clostridioides difficile infection (CDI) has been primarily associated with the toxin B (TcdB), one of the three known protein toxins secreted by C. difficile, which can activate the intestinal immune system a...
Hydrochloric acid-treated Bacillus subtilis ghosts induce IL-1 beta, IL-6, and TNF-alpha in murine macrophage [0.03%]
枯草芽孢杆菌鬼细胞诱导小鼠巨噬细胞释放白细胞介素-1、白细胞介素-6和肿瘤坏死因子-α
Young-Min Kim,Kwang-Su Lee,Won-Mun Kim et al.
Young-Min Kim et al.
Background: Bacterial ghosts (BGs) are empty cell envelopes commonly generated using Gram-negative bacteria; they represent a potential platform for efficient adjuvant and vaccine delivery systems. However, the efficient ...
Ferulic acid exhibits anti-inflammatory effects by inducing autophagy and blocking NLRP3 inflammasome activation [0.03%]
丁香酸通过诱导自噬和阻断NLRP3炎性小体活化发挥抗炎作用
Yongjuan Liu,Lu Shi,Wenhong Qiu et al.
Yongjuan Liu et al.
Background: Inflammation is involved in the healing process; however, when inflammation is overactivated, multiple diseases can occur. The continued discovery of new anti-inflammatory drugs is crucial in the treatment of ...
Modifications of mRNA vaccine structural elements for improving mRNA stability and translation efficiency [0.03%]
修改mRNA疫苗的结构成分以提高mRNA的稳定性和翻译效率
Sun Chang Kim,Simranjeet Singh Sekhon,Woo-Ri Shin et al.
Sun Chang Kim et al.
Background: mRNA vaccines hold great potential as therapeutic techniques against viral infections due to their efficacy, safety, and large-scale production. mRNA vaccines offer flexibility in development as any protein ca...
Application of the adverse outcome pathway framework to predict the toxicity of chemicals in the semiconductor manufacturing industry [0.03%]
毒性途径框架在预测半导体行业化学品毒性中的应用研究
Kyung-Taek Rim
Kyung-Taek Rim
Background: To solve current issues using big data, solve current issues related to the semiconductor and electronics industry, I tried to establish the data for each toxicity mechanism for adverse outcome pathway (AOP) f...