Ibudilast: a non‑selective phosphodiesterase inhibitor in brain disorders [0.03%]
Ibudilast：脑疾病中的非选择性磷酸二酯酶抑制剂
Joanna Schwenkgrub,Małgorzata Zaremba,Dagmara Mirowska-Guzel et al.
Joanna Schwenkgrub et al.
Ibudilast (IBD) is a non‑selective (3, 4, 10, 11) phosphodiesterase (PDE) inhibitor, used mainly as a bronchodilator for the treatment of bronchial asthma. PDE play a central role in cellular function (e.g. differentiation, synaptic plasti...
Justyna Żwawiak,Lucjusz Zaprutko
Justyna Żwawiak
Nowadays, dynamic development in nanotechnological sciences is observed. Nanoparticles are frequently used in medicine and pharmacy as delivery systems for different kinds of active substances. One of the latest developed substances, with a...
Jacek Lenart
Jacek Lenart
Neurons vary widely in shape, size, type of neurotransmitters and number of synapses. Their common characteristic is a very high sensitivity to changes in oxygen concentration. The consequence of hypoxia is to launch a series of biochemical...
Magdalena Stojek
Magdalena Stojek
Adipose tissue is not merely a storage depot of triacylglycerols but also a major endocrine organ. Its cells, including adipocytes, synthesize and secrete a range of biologically active molecules termed adipokines. Adipokines that display t...
Anna Bizoń,Kinga Jędryczko,Halina Milnerowicz
Anna Bizoń
Metallothionein is cysteine-rich low molecular mass protein. The involvement of MT in many physiological and pathophysiological processes such as apoptosis, proliferation, angiogenesis, and the detoxification of heavy metals suggested parti...
Paweł Kalinowski,Anna Grządziel
Paweł Kalinowski
Introduction: Secondary prophylaxis of cervical cancer consisting in cytology screening tests, despite its effectiveness, does not achieve the desired results. For several years, primary prophylaxis has been available in ...
Pathogenic factors of Pseudomonas aeruginosa - the role of biofilm in pathogenicity and as a target for phage therapy [0.03%]
铜绿假单胞菌的致病因子——生物膜在致病性和噬菌体治疗中的作用
Fairoz Al-Wrafy,Ewa Brzozowska,Sabina Górska et al.
Fairoz Al-Wrafy et al.
Pseudomonas aeruginosa is an opportunistic pathogen that can cause several acute and chronic infections in humans, and it has become an important cause of nosocomial infections and antibiotic resistance. Biofilm represents an important viru...
Zofia Zwolska,Ewa Augustynowicz-Kopeć
Zofia Zwolska
Leprosy or Hansen disease is caused by an infection of Mycobacterium leprae. The large number of undetected cases (2000-2012 years 4 mln people) remains a threat to the elimination of leprosy. Leprosy is an unheard in Poland and generally i...
Marcin Dziedzic,Ewelina Orłowska,Tomasz Powrózek et al.
Marcin Dziedzic et al.
MicroRNA (miRNA) belongs to the family of non-coding RNAs, which posttranscriptionally regulate gene function. Moreover, accumulating evidence points to an essential role of miRNAs in development and monitoring of kidney disease, though the...
The role of oxidative stress and NADPH oxidase in the pathogenesis of atherosclerosis [0.03%]
氧化应激和NADPH氧化酶在动脉粥样硬化发生发展中的作用研究进展
Dorota Bryk,Wioletta Olejarz,Danuta Zapolska-Downar
Dorota Bryk
Reactive oxygen species (ROS) play a key role in the pathogenesis of atherosclerosis. The main mechanisms which are involved are low-density lipoprotein oxidative modification, inactivation of nitric oxide and modulation of redox-sensitive ...