Stigmatization in dermatology with a special focus on psoriatic patients [0.03%]
皮肤病学中的标签化现象及其对银屑病患者的特殊影响
Dimitre Dimitrov,Jacek C Szepietowski
Dimitre Dimitrov
A stigma is currently defined as a discrediting mark, biological or social, that sets a person off from others and disrupts interactions with them. People who differ from social norms in some respect are often negatively labeled. A number o...
Epigenetic modifications: An important mechanism in diabetic disturbances [0.03%]
表观遗传修饰在糖尿病发病机制中的重要作用
Anna Rorbach-Dolata,Adriana Kubis,Agnieszka Piwowar
Anna Rorbach-Dolata
In the search for explanations of diabetes pathomechanisms, especially the development of its vascular complications (micro- and macrovascular ), although current, good metabolic control of diabetes, attention was drawn to the role of epige...
3-Bromopyruvate as a potential pharmaceutical in the light of experimental data [0.03%]
基于实验数据的3-溴丙酮酸作为潜在药物的可能性
Izabela Szczuka,Andrzej Gamian,Grzegorz Terlecki
Izabela Szczuka
3-Bromopyruvate (3-BrPA) is an halogenated analogue of pyruvic acid known for over four decades as an alkylating agent reacting with thiol groups of many proteins. It enters animal cells like a lactate: via monocarboxylic acid transporters....
Piotr Bialik,Katarzyna Woźniak
Piotr Bialik
Sumoylation is one of the post-translational modifications of proteins, responsible for the regulation of many cellular processes, such as DNA replication and repair, transcription, signal transduction and nuclear transport. During sumoylat...
Structure of bacterial chromosome: An analysis of DNA-protein interactions in vivo [0.03%]
细菌染色体的结构——对活细胞中DNA-蛋白质相互作用的研究
Joanna Hołówka,Małgorzata Płachetka
Joanna Hołówka
According to recent reports, bacterial chromosomes exhibit a hierarchical organization. The number of proteins that bind DNA are responsible for local and global organization of the DNA ensuring proper chromosome compaction. Advanced molecu...
Perspective in optimization of stem cell therapies for heart regeneration [0.03%]
论优化诱导多能干细胞技术用于心脏再生医学的策略与前景
Paulina Gapska,Maciej Kurpisz
Paulina Gapska
There is a variety of mechanisms(s) factor(s) that may influence stem cell therapies for heart regeneration. Among the best candidates for stem cell source are: mesenchymal stem cells (also those isolated from adipose tissue), cardiac cell ...
Viability and growth promotion of starter and probiotic bacteria in yogurt supplemented with whey protein hydrolysate during refrigerated storage [0.03%]
添加乳清蛋白水解物的酸奶在冷藏贮藏期间益生菌和发酵菌株的存活及生长促进作用的研究
Anna Dąbrowska,Konrad Babij,Marek Szołtysik et al.
Anna Dąbrowska et al.
The effect of whey protein hydrolysate (WPH) addition on growth of standard yoghurt cultures and Bifidobacterium adolescentis during co-fermentation and its viability during storage at 4ºC in yoghurts has been evaluated. WPH was obtained w...
Between biology and medicine: perspectives on the use of dendritic cells in anticancer therapy [0.03%]
介于生物学和医学之间：关于树突状细胞在抗癌治疗中应用的展望
Agnieszka Szczygieł,Elżbieta Pajtasz-Piasecka
Agnieszka Szczygieł
Dendritic cells (DCs), as a link between innate and adaptive immunity, play a pivotal role in maintaining homeostasis of the immune system. The DC population is characterized by heterogeneity; it consists of many subpopulations which, despi...
GPR120: Mechanism of action, role and potential for medical applications [0.03%]
GPR120：作用机制、功能及潜在医学应用前景
Hanna Karakuła-Juchnowicz,Joanna Róg,Dariusz Juchnowicz et al.
Hanna Karakuła-Juchnowicz et al.
G protein-coupled receptors (GPCRs) constitute a family of transmembrane proteins that mediate many cellular processes. GPR120/FFAR4, a receptor from this family that is activated by fatty acids, has received considerable attention recently...
The mRNA expression levels of uncoupling proteins 1 and 2 in mononuclear cells from patients with metabolic disorders: obesity and type 2 diabetes mellitus [0.03%]
肥胖和2型糖尿病患者单核细胞解偶联蛋白1和2的mRNA表达水平
Sona Margaryan,Agata Witkowicz,Anna Partyka et al.
Sona Margaryan et al.
Introduction: Type 2 diabetes mellitus (T2DM) and obesity are metabolic disorders whose major hallmark is insulin resistance. Impaired mitochondrial activity, such as reduced ratio of energy production to respiration, has...