The cell on the edge of life and death: Crosstalk between autophagy and apoptosis [0.03%]
生死边缘的细胞：自噬与凋亡之间的对话
Daniela Kasprowska-Liśkiewicz
Daniela Kasprowska-Liśkiewicz
Recently, the crosstalk between autophagy and apoptosis has attracted broader attention. Basal autophagy serves to maintain cell homeostasis, while the upregulation of this process is an element of stress response that enables the cell to s...
Agnieszka Owczarczyk-Saczonek,Waldemar Placek
Agnieszka Owczarczyk-Saczonek
Many epidemiological studies have confirmed the relationship of obesity and psoriasis, and it is believed that obesity is an independent risk factor for its development and is associated with a worse prognosis. Furthermore, the reduction of...
The pathophysiological basis of the protective effects of metformin in heart failure [0.03%]
二甲双胍在心力衰竭中保护作用的病理生理学基础
Aleksandra Dziubak,Grażyna Wójcicka
Aleksandra Dziubak
Metformin, currently recommended as the drug of first choice in type 2 diabetes mellitus (T2DM), is one of the few antihiperglycemic drugs to reduce cardiovascular risk. Nonetheless, due to the risk of lactic acidosis during metformin thera...
Magdalena Panek-Jeziorna,Agata Mulak
Magdalena Panek-Jeziorna
Bile acids not only play a cardinal role in the digestion and absorption of fat and fat-soluble vitamins, but also significantly affect gastrointestinal motor, sensory and secretory functions, intestinal barrier permeability and the regulat...
Jolanta Guz,Ryszard Oliński
Jolanta Guz
Vitamin C (L-ascorbic acid) is a micronutrient best known for its anti-scurvy activity in humans. Vitamin C is involved in many biological processes involving enzymatic reactions that are catalyzed by members of dioxygenases which use Fe(II...
The role of trophic factors and inflammatory processes in physical activity-induced neuroprotection in Parkinson's disease [0.03%]
营养因子和炎症过程在帕金森病运动保护中的作用
Ewelina Pałasz,Agnieszka Bąk,Anna Gąsiorowska et al.
Ewelina Pałasz et al.
Glial cells and neurotrophins play an important role in maintaining homeostasis of the CNS. Disturbances of their function can lead to a number of nervous system diseases, including Parkinson's disease (PD). Current clinical studies provide...
Łukasz Michalak,Magdalena Bulska,Karolina Strząbała et al.
Łukasz Michalak et al.
Neopterin is a pyrazino-pyrimidine compound that belongs to the pteridine group. It is known to be a biochemical marker associated with cell-mediated immunity. It is produced by human monocytes/macrophages and dendritic cells from guanosine...
Łukasz Gąsior,Regina Daszkiewicz,Mateusz Ogórek et al.
Łukasz Gąsior et al.
In most animal species female germ cells are the source of mitochondrial genome for the whole body of individuals. As a source of mitochondrial DNA for future generations the mitochondria in the female germ line undergo dynamic quantitative...
Immune disorders in sepsis and their treatment as a significant problem of modern intensive care [0.03%]
脓毒症的免疫障碍及其作为现代重症医学重要问题的治疗措施
Lidia Łysenko,Patrycja Leśnik,Kamil Nelke et al.
Lidia Łysenko et al.
Despite the great advances in the treatment of sepsis over the past 20 years, sepsis remains the main cause of death in intensive care units. In the context of new possibilities of treating sepsis, a comprehensive response of the immune sys...
Beata Szymańska,Anna Długosz
Beata Szymańska
Bladder cancer (BC) affects usually older people. According to information provided by the National Cancer Registry in 2012. BC was the 4th, in terms of illness, cancer in men and 11th in women. Early diagnosis of bladder cancer is importan...