Introducing New Inhibitors of PAICS, a De Novo Purine Biosynthesis Enzyme, through Structure-Based Virtual Screening [0.03%]
基于结构的虚拟筛选获得新型PAICS抑制剂
Reyhane Chamani,Mohammad Hosein Darvand Araghi
Reyhane Chamani
Background: Cancer cells need many purine nucleotides during their uncontrolled proliferation. phosphoribosyl-aminoimidazole carboxylase and phosphoribosylaminoimidazole-succinocarboxamide synthetase (PAICS) is one of the...
Validation of the Mechanism of Action of TYROBP Related to Blood-Brain Barrier Function in Intracerebral Hemorrhage by Bioinformatics Analysis [0.03%]
通过生物信息学分析验证TYROBP在脑出血中与血脑屏障功能相关的作用机制
Chengyuan Ji,Dejing Cheng,Siyuan Yang et al.
Chengyuan Ji et al.
Background: Intracerebral hemorrhage (ICH) is an extremely common acute vascular disease in the elderly population with a high potential for disability and death. ...
In vitro Evaluation of the Cytotoxic Effects of a Recombinant form of the Soluble Mutant IL-6 Receptor on an Ovarian Cancer Cell Line [0.03%]
一种可溶型重组IL-6突变体受体的体外细胞毒性评估研究卵巢癌细胞系
Kosar Khatir,Mahmoud Aghaei,Seyedeh Sara Ghorbanhosseini et al.
Kosar Khatir et al.
Background: Interleukin-6 (IL-6) plays an important role in cancer metastasis. Therefore, it seems that inhibition of IL-6 may act as an anticancer agent. ...
NNT-AS1, A Long Non-coding RNA with Therapeutic Promise in Mycoplasma Pneumoniae Pneumonia via the Mir-410-3p/TMEM14A/Wnt/ΒCatenin Signalling Pathway [0.03%]
长链非编码RNA NNT-AS1通过Mir-410-3p/TMEM14A/Wnt/β-catenin信号通路在肺炎支原体肺炎中展现出治疗潜力
Yingjuan Yuan,Yue Zhou
Yingjuan Yuan
Background: Long non-coding RNA (lncRNA) NNT-AS1 is involved in the progression of various lung and inflammatory diseases, and has been reported to be upregulated in patients with Mycoplasma pneumoniae pneumonia (MPP). Ho...
The Regulatory Effect of Human Umbilical Cord Mesenchymal Stem Cells on the Gut Microbiota in Diabetic Nephropathy Rats [0.03%]
人脐带间充质干细胞对糖尿病肾病大鼠肠道菌群的调控作用
Chengdong Wu,Yan Mi,Jixuan Song et al.
Chengdong Wu et al.
Background: Chronic inflammation is increasingly recognized as a key factor in the progression of diabetic kidney disease (DKD). By discovering that the regulation of gut microbiota plays an important role in diabetic kid...
Aptamers in Combination Therapies for Enhanced Radiosensitization in Cancer [0.03%]
结合疗法中适配子增强癌症放射增敏作用
Abolfazl Bemidinezhad,Yasaman Abolhassani,Arsalan Sarabian Tabrizi et al.
Abolfazl Bemidinezhad et al.
This review explores the emerging role of aptamers in enhancing radiotherapy (RT) efficacy through their ability to target tumor sites with high specificity. Cancer, a complex disease, involves uncontrolled cell growth, and radiosensitizati...
Tissue-Specific Antioxidant Responses and PAL Gene Expression in Bread Wheat Under Drought Stress [0.03%]
干旱胁迫下普通小麦组织特异的抗氧化响应及PAL基因表达模式分析
Fateme Tanbakuyi,Mehrdad Chaichi,Khadijeh Razavi et al.
Fateme Tanbakuyi et al.
Background: Drought stress affects crop wheat productivity by inducing biochemical changes in different tissues. Antioxidant enzymes, phenolic compounds and sugars are crucial in the plant's defense against stress. Studyi...
Co-Infection of Cucumber Mosaic Virus Stabilized Its Recombinant Coat Protein Expressed by Zucchini Yellow Mosaic Virus [0.03%]
cucumber mosaic病毒的感染稳定了由zucchini yellow Mosaic 病毒表达的重组包涵体蛋白
Sayed Mohsen Nassaj Hosseini,Masoud Shams-Bakhsh,Shyi Dong Yeh
Sayed Mohsen Nassaj Hosseini
Objective: This study aimed to investigate why the recombinant coat protein (CP) of cucumber mosaic virus (CMV) is undetectable when expressed by zucchini yellow mosaic virus (ZYMV) but becomes highly detectable during mi...
Recombinant Antimicrobial Peptides (rAMPs); Potential Applications in Medicine and Veterinary Medicine: A Review [0.03%]
重组抗菌肽(rAMPs)在医学和兽医中的潜在应用：综述
Amir Asghari Baghkheirati,Reza Golmohammadi,Mohammad Hadi Sekhavati et al.
Amir Asghari Baghkheirati et al.
Antibiotic resistance has become a major public health concern worldwide. Treatment of humans and animals is becoming increasingly challenging due to antibiotic resistance. Antibiotic-resistant bacteria can be transmitted from animals to hu...
A Review on the Impact of Aberrant Methylation in Breast Cancer: Diagnostic, Prognostic, and Therapeutic Approaches [0.03%]
乳腺癌异常甲基化的研究及其在诊断、预后和治疗中的应用综述
Majid Hosseini,Saba Feghhi-Najafabadi,Mehdi Azad
Majid Hosseini
Breast cancer (BC) is still a major global health concern, and a key factor in its pathophysiology is epigenetic abnormalities, specifically DNA methylation and histone modifications. This review offers a thorough examination of current res...