Structure-Guided Discovery of Drug-like Compounds Targeting HPV16 E6 for Antiviral Therapy Development [0.03%]
基于结构的发现靶向HPV16 E6的药物类似物以开发抗病毒疗法
Jingying Shang,Qifan Jiang,Ting Liu et al.
Jingying Shang et al.
Background: Human papillomavirus type 16 (HPV16) E6 oncoprotein is a key factor in the progression of cervical and other HPV-related cancers. Targeting E6 with small molecule inhibitors represents a promising strategy for...
Mathematical Modeling and Thermodynamic Integration for Precision PCR Optimization [0.03%]
精准PCR优化的数学建模与热力学集成方法
Hadja Fatima Tbahriti,Aicha Zerrouki,Fatima Zohra Mahammi et al.
Hadja Fatima Tbahriti et al.
Objectives: The objective of this study was to develop a predictive modeling framework for optimizing MgCl2 concentration and melting temperature (Tm) in PCR conditions. ...
Identification and Validation of Tumorigenesis Related Hub Genes in Hepatocellular Carcinoma via Integrated Bioinformatics Analysis [0.03%]
基于整合生物信息学分析的肝细胞癌致瘤相关关键基因鉴定及验证
Chuanlong Yang,Shanliang Ju,Yican Li et al.
Chuanlong Yang et al.
Background: Hepatocellular carcinoma (HCC) is a heterogeneous liver cancer with poor prognosis and diverse etiologies, yet molecular mechanisms across different causes remain unclear. ...
Combination Therapy Using Heat-Killed Lactobacillus Casei and Bacillus Coagulans Along with Alpha-Galactosyl Ceramide in a Mouse Model of Colorectal Cancer [0.03%]
一种鼠源结直肠癌模型联合热灭活干酪乳杆菌和凝结芽孢杆菌以及α-半乳糖神经酰胺的疗法
Ali Miri,Hadi Esmaeili Gouvarchinghaleh,Mohammad Reza Heydari et al.
Ali Miri et al.
Background: Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Current treatments for CRC, in addition to side effects, face limitations such as drug resistance and selective ineffectiveness, whi...
CircFNIP1 Regulates Proliferation and Invasion in Lung Cancer Cells and Represents a Potential Therapeutic Target [0.03%]
CircFNIP1调节肺癌细胞增殖和侵袭，是潜在的治疗靶点
Dan Lan,Yingjun Liu,Yan Zhang et al.
Dan Lan et al.
Background: Lung cancer (LC) remains the leading cause of cancer-related mortality. Circular RNAs (circRNAs) are emerging as important regulators in cancer biology. ...
Comprehensive Bioinformatic Analysis Reveals Survival-Associated Hub Genes and MicroRNAs in Multiple Myeloma Patients [0.03%]
全面的生物信息学分析揭示了多发性骨髓瘤患者的生存相关关键基因和微小核糖核酸
Elham Hatef,Reza Bayat,Elahe Seyed Hosseini et al.
Elham Hatef et al.
Background: Multiple myeloma (MM) is a B-cell malignancy characterized by clonal plasma cell proliferation in the bone marrow. Although significant advances have been achieved in treatment, it remains largely incurable, a...
Single-Cell RNA-Seq Dissects Specific Marker in Glioblastoma Based on Gene Regulatory Networks [0.03%]
单细胞RNA测序基于基因调控网络解析胶质母细胞瘤特异性标记物
Shenglan Li,Yanjie Lan,Jiachen Wang et al.
Shenglan Li et al.
Background: Glioblastoma (GBM) is one of the most aggressive and common tumors of the central nervous system (CNS), distinguished by its significant intratumoral heterogeneity and poor prognosis, with a median overall sur...
Development of a CTL Epitope-Based Vaccine Targeting Tumor Antigens in Esophageal Cancer: An Immunoinformatic Study [0.03%]
基于CTL表位的食管癌肿瘤抗原疫苗免疫信息学研究及发展
Hongyou Cao,Fengjiao Ding
Hongyou Cao
Background: Esophageal cancer is a highly aggressive malignancy with poor global survival rates and limited efficacy from conventional therapies. Immunotherapy has shown promise, yet its effectiveness remains limited as a...
Bioassay-Guided Purification of Cytotoxic Isoflavonoids and Sesquiterpenoids of Streptomyces coelicolor Isolated from Marine Sponge Axinella sinoxea, and In Silico Target Prediction [0.03%]
从海绵海绵孔轴藻中分离的链霉菌素蓝氏菌的细胞毒异黄酮和倍半萜类化合物的生物测定指导纯化及预测计算靶点
Maryam Alborz,Mohsen Gozari,Omidreza Firuzi et al.
Maryam Alborz et al.
Background: The unique marine habitat of the Persian Gulf offers a specific environment for the sponges and their associated bacteria to produce bioactive specialized metabolites. ...
Utilizing Circulating MicroRNAs for Personalized Exercise Programs: Insights into Physiological Adaptations and Individual Responses [0.03%]
利用循环microRNA进行个性化运动程序的制定：生理适应和个体反应的新见解
Zhanguo Su,Li Chen
Zhanguo Su
Evidence acquisition: This narrative review included articles sourced from databases such as PubMed, Google Scholar, ScienceDirect, Web of Science, and Scopus, without time limitations. Studies on c-miRNAs related to exer...