Therapeutic Potential of Ginkgolic Acid C17:1 in Modulating PTEN/mtDNA/TLR9 Axis for Alleviating Chronic Pseudomonas Aeruginosa Infection in Bronchiectasis [0.03%]
银杏酸C17：1治疗潜力通过调节PTEN/mtDNA/TLR9轴缓解支气管扩张慢性绿脓杆菌感染
Shuke Rao,Huiyan Jiang,Jieyi Huang et al.
Shuke Rao et al.
Background: Pseudomonas aeruginosa (PA) colonization drives persistent infection and inflammation in bronchiectasis, a condition lacking targeted biotherapies. Phosphatase and tensin homolog (PTEN) is a key regulator of i...
Exploring the Dynamic Interplay of Carbon Nanotubes with Apoptosis In-vitro and In-vivo: Insights from Bcl-2 and IAP Families [0.03%]
基于Bcl-2和IAP家族的碳纳米管在体外和体内的动态相互作用及其对凋亡影响的研究
Shirin Lotfipanah,Leila Saremi,Yasaminsadat Rafieitabatabaei et al.
Shirin Lotfipanah et al.
Background: Carbon nanotubes (CNTs) are carbon-based nanomaterials. They have been widely used in environmental technologies and in biomedical fields. Obj...
Analysis of Gut Microbiota Metabolites in Chronic Kidney Disease-Associated Pruritus Using Network Pharmacology and Molecular Docking [0.03%]
基于网络药理学和分子对接的慢性肾脏病相关瘙痒肠道微生物代谢物分析
Lingling Sun,Yining He,Min Jiang et al.
Lingling Sun et al.
Background: Chronic kidney disease-associated pruritus (CKD-aP) remains a frequent and distressing symptom in patients with renal dysfunction, yet its biological mechanisms are still not well defined. Growing evidence sug...
In vivo Reverse Transcription of A Heterologous RNA Virus by Cauliflower Mosaic Virus Reverse Transcriptase During Co-Infection [0.03%]
芸苔素病毒反转录酶的反式活化作用及病毒感染中的链特异性反转录反应
Hakimeh Ighani Mayan,Nemat Sokhandan Bashir,Davoud Koolivand
Hakimeh Ighani Mayan
Background: Reverse transcriptase (RT) is central to the replication of retroviruses and pararetroviruses. Cauliflower mosaic virus (CaMV), a plant pararetrovirus, replicates via RT using its own viral RNA. Simultaneous i...
Serum GPX4 and LPO as Biomarkers for Perioperative Oxidative Stress: Impact of Ciprofol Anesthesia in A Randomized Controlled Trial [0.03%]
血清GPX4和LPO作为围手术期氧化应激生物标志物的影响：环丙烷麻醉的随机对照试验中的作用
Qiuyuan Ji,Yongheng Hou
Qiuyuan Ji
Background: Perioperative oxidative stress contributes to postoperative organ dysfunction, but sensitive mechanistic biomarkers are limited. Objectives: ...
Screening of Biomarkers Related to Mitophagy in Severe Pancreatitis Based on Bioinformatics Methods [0.03%]
基于生物信息学方法筛选与严重胰腺炎相关的线粒体自噬标志物
Jiajia Li,Jinxin Cao,Zhipeng Wu et al.
Jiajia Li et al.
Objectives: This study aimed to identify mitophagy-related biomarkers in severe acute pancreatitis through integrated bioinformatics and machine-learning approaches, and to elucidate their potential regulatory mechanisms ...
Targeting TPX2 to Enhance Metastasis Control and Radiosensitivity in Esophageal Squamous Cell Carcinoma Through PI3K/AKT Pathway Modulation [0.03%]
靶向TPX2通过调节PI3K / AKT途径来增强食管鳞状细胞癌的转移控制和放射敏感性
Fang Meng,Jiaru Hu,Shiqiang Zhang et al.
Fang Meng et al.
Background: Esophageal squamous cell carcinoma (ESCC) faces challenges of metastasis and variable radiosensitivity. The role of Targeting Protein for Xenopus Kinesin-like Protein 2 (TPX2) in regulating these ESCC-related ...
Effects of Gut Microbiome and Metabolic Pathways on Obesity: A Two-Sample Mendelian Randomization and Case-Control Study [0.03%]
肠道微生物组和代谢途径对肥胖影响的双向孟德尔随机化及病例对照研究
Xiaoyu Fu,Yu Xia,Jing Han et al.
Xiaoyu Fu et al.
Objectives: We employed Mendelian randomization (MR) and case-control studies to identify causal associations and validate biological relevance. Materials...
From Breakthrough to Access: How Biotechnology and Artificial Intelligence are Reshaping the Scalability and Precision of Cancer Immunotherapy [0.03%]
从突破到普及：生物技术与人工智能如何重塑癌症免疫疗法的 scalability 和 precision
Babak Jahangiri,Elahe Asadollahi,Alireza Zomorodipour
Babak Jahangiri
Application Value of Multi-Gene Testing in the Evaluation of Benign and Malignant Thyroid Nodules [0.03%]
甲状腺结节良恶性鉴别诊断中多基因检测的应用价值评估
Murui Zhang,Lei Xie,Fei Xu et al.
Murui Zhang et al.
Background: Thyroid nodules are highly prevalent in clinical practice, and accurate preoperative distinction between benign and malignant lesions remains a major diagnostic challenge. ...