Pharmaceutical Utilization Review: A Five-Year Time Trend Analysis of the Pharmaceutical Market in Iran [0.03%]
伊朗医药利用回顾：对伊朗医药市场五年的趋势分析
Mohammadamir Nemati,Behzad Fatemi,Fatemeh Soleymani et al.
Mohammadamir Nemati et al.
Background and objectives: The primary objective of this study was to compare the total and insurance-covered utilization of pharmaceuticals in Iran from March 2018 to March 2023. The findings of this study can offer valu...
Dual TYK2/JAK1 Inhibition by Brepocitinib Reprograms Synoviocyte Pathobiology: Mechanistic Insights Into Targeted Therapy for Rheumatoid Arthritis [0.03%]
TYK2和JAK1双重抑制剂Brepocitinib通过重塑滑膜细胞病理生物学对类风湿性关节炎进行靶向治疗的机制研究
Umar Saeed,Zahra Zahid Piracha,Andromeda M Nauli et al.
Umar Saeed et al.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial hyperplasia, persistent inflammation, and joint destruction. Targeted inhibition of intracellular signaling pathways, such a...
Comparison of the Effects of Sevoflurane and Isoflurane During Liver Transplant Surgery on the Short-Term Cardiac, Hepatic, and Renal Outcome: A Randomized Clinical Trial [0.03%]
异氟醚与七氟醚对肝移植术中短期心脏、肝脏及肾脏结局影响的比较：一项随机临床试验
Mohammadreza Moshari,Sadaf Tahery,Mastaneh Dahi Taleghani et al.
Mohammadreza Moshari et al.
Background: Liver transplantation is frequently complicated by ischemia-reperfusion injury (IRI), which may impair hepatic, renal, and cardiac function. Volatile anesthetics such as isoflurane and sevoflurane are believed...
Innovative Peptide Therapeutics for SARS-CoV-2: Design, Docking, and Functional Analysis [0.03%]
用于SARS-CoV-2的创新肽类药物的设计、对接和功能分析研究
Samaneh Karimkhanilouei,Saeid Ghorbian,Sanaz Mahmazi et al.
Samaneh Karimkhanilouei et al.
Background: The continuous emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants necessitates the rapid development of novel therapeutics, particularly those targeting conserved viral proteins...
Effect of Lemon Inhalation Aromatherapy on Postoperative Pain, Nausea and Vomiting, Delirium, and Inflammatory Markers After Coronary Artery Bypass Grafting: A Triple-Blind Randomized Trial [0.03%]
柠檬吸入芳香疗法对冠状动脉旁路移植术后疼痛、恶心呕吐、谵妄和炎症标志物影响的三盲随机对照试验
Siavash Sangi,Seyed Mohammadreza Amouzegar Zavareh,Hedayat Sahraei et al.
Siavash Sangi et al.
Background: Complementary and integrative medicine has gained increasing attention as a safe adjunct for improving postoperative outcomes, particularly in cardiac surgery where pain, postoperative nausea and vomiting (PON...
MEK1/2 Inhibitor (U0126) and PI3K Inhibitor (LY294002) Suppress Herpes Simplex Virus Type 1 Replication by Targeting MAPK/ERK1/2 and PI3K/AKT Signaling Pathways: Implications for Oral Health and Translational Control of Orolabial HSV-1 Infection [0.03%]
MEK1/2抑制剂（U0126）和PI3K抑制剂（LY294002）通过靶向MAPK/ERK1/2和PI3K/AKT信号通路抑制单纯疱疹病毒1型复制：对口腔健康和口唇HSV-1感染的转化控制的意义
Wei Meng,Zahra Zahid Piracha,Umar Saeed et al.
Wei Meng et al.
Background: Current antivirals for orolabial Herpes simplex virus type 1 (HSV-1) often provide incomplete suppression and limited reactivation control, sustaining recurrent oral lesions and inflammation that compromise or...
Quercetin-Loaded Avocado Oil Nanoemulsion Reverses High-fat and High-carbohydrate Diet-Induced Testicular Dysfunction: Role of Oxidative Stress and NPY Signaling in a Randomized Trial [0.03%]
檞皮素载牛油果油纳米乳对高脂高碳饮食诱导的小鼠睾丸功能障碍的逆转作用：随机试验中的氧化应激和NPY信号的作用机制研究
Hamidreza Mazangi,Negar Panahi,Saeed Hesaraki et al.
Hamidreza Mazangi et al.
Background: High-fat and high-carbohydrate diets (HF) can negatively affect male reproductive function, impairing spermatogenesis and testosterone production. Quercetin (Qu) may mitigate testicular damage, but its effecti...
Design and Optimization of Chitosan/Montmorillonite Nanoparticle for Sustained Vancomycin Delivery in Peri-implantitis [0.03%]
壳聚糖/蒙脱石纳米颗粒的 design 及优化以用于牙植入病的长效万古霉素缓释
Shima Esmailzadeh,Taherehsadat Jafarzadeh,Mohammad Moazen
Shima Esmailzadeh
Background: Dental implants are increasingly utilized to replace lost teeth; however, peri-implantitis - a condition primarily caused by bacterial plaque - poses substantial challenges to maintaining implant success and t...
Evaluating the Impact of Strategic Alignment on Performance Components of Iranian Pharmaceutical Companies Using Machine Learning Techniques [0.03%]
利用机器学习技术评估战略一致性对伊朗制药公司绩效组件的影响
Simin Sadeghi,Mahdi Mohammadzadeh
Simin Sadeghi
Background: Sustainable performance in the pharmaceutical industry hinges on the strategic alignment of human resources (HR), marketing, and information technology (IT). Prior studies often examined these domains separate...
Daphnetin Ameliorates the Amyloid β-Induced Alzheimer Disease via Restoring Potassium-Chloride Co-Transporter 2 (KCC2) Ion Channel Functions in Mice [0.03%]
番红花素通过在小鼠中恢复钾氯共转运蛋白2 (KCC2) 离子通道功能来改善淀粉样β诱导的阿尔茨海默病
Yanyan Zhou,Fang Zhou,Hongbin Li
Yanyan Zhou
Background: Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by downregulation of potassium voltage-gated channel subfamily a member 2 (KCNA2) proteins. Potassium voltage-gated channel subfam...