miR-146a-Enriched Mesenchymal Stem Cell-Derived Extracellular Vesicles Prolong Corneal Allograft Survival by Modulating Local and Systemic Immune Responses [0.03%]
富含miR-146a的间充质干细胞源性细胞外囊泡通过调节局部和全身免疫反应延长角膜移植存活率
Xuting He
Xuting He
Background: Corneal allograft rejection remains a leading cause of graft failure. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) may provide new options for modulating the immune response to allografts. ...
Hepatic Inflammation and Apoptosis in Socially Isolated Rats: Effects of Vortioxetine Treatment [0.03%]
社交隔离大鼠肝炎和凋亡以及伏硫西治疗对其影响
Neziha Senem Arı,Merve Akkuş,Hatice Solak et al.
Neziha Senem Arı et al.
Background: Depression and chronic psychosocial stress can induce systemic inflammation and oxidative stress that may extend beyond the central nervous system to peripheral organs such as the liver. Social isolation is a ...
Dendrobium officinale Polysaccharide Promotes Infected Wound Healing Through SIRT1-Regulated HMGB1-K29 Deacetylation and NF-κB Inhibition [0.03%]
石斛多糖通过SIRT1介导的HMGB1 K29去乙酰化抑制NF-κB促进感染创面修复
Yutong Wu,Mohd Hasmizam Razali,Wentao Wu
Yutong Wu
Background: Two major challenges frequently encountered during wound healing are excessive inflammatory responses and bacterial infection. Dendrobium officinale polysaccharide (DOP), a major bioactive constituent of Dendr...
Investigating the Anti-inflammatory Mechanism of Alpinia purpurata (Vieill.) K. Schum. Rhizome Extract: Metabolite Profiling, Network Pharmacology, in vitro Safety, and in vivo Validation [0.03%]
采用代谢组学、网络药理学等方法探究山奈根抗炎机制的研究：体外安全性评价及体内验证
Kiki Mulkiya Yuliawati,Fahriza Salsabilla Yuniar,Ellin Febrina et al.
Kiki Mulkiya Yuliawati et al.
Background: Alpinia purpurata has shown promising effects in alleviating inflammatory conditions; however, its underlying mechanisms require further investigation. ...
Andrographolide Alleviates Mycoplasma pneumoniae Pneumonia in Children by Inhibiting Alveolar Epithelial Cell Pyroptosis Through the HMGB1/TLR4/NF-κB Pathway [0.03%]
andrographolide通过HMGB1/TLR4/NF-κB途径抑制肺泡上皮细胞pyroptosis缓解儿童肺炎支原体肺炎
Lijuan Zhang,Umar Saeed,Rui Gao
Lijuan Zhang
Background: Mycoplasma pneumoniae pneumonia (MPP) is a pulmonary inflammatory disease caused by Mycoplasma pneumoniae (Mp) infection that primarily involves the bronchi, alveoli, and pulmonary interstitium. It is the most...
Metformin Attenuates Angiotensin II-Induced Cardiac Inflammaging-Like Injury Through Coordinated Nrf2 Activation and NF-κB Suppression [0.03%]
二甲双胍通过协调激活Nrf2和抑制NF-κB来缓解血管紧张素II诱导的心脏炎症老化损伤
Huarui Li,Deming Fu,Umar Saeed et al.
Huarui Li et al.
Background: Age-related cardiomyocyte vulnerability is driven by a convergent triad of persistent oxidative stress, chronic low-grade inflammation, and senescence-like signaling, which together accelerate functional decli...
Tehranolide Attenuates Lipid Accumulation in Steatotic HepG2 Cells via cAMP/AMPK/SIRT1-Mediated Autophagy Activation [0.03%]
藤菊内酯通过cAMP/AMPK/SIRT1介导的自噬激活缓解肝癌细胞脂质蓄积
Shima Lorestani,Shahla Mohammad Ganji,Shokoofe Noori
Shima Lorestani
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic condition marked by abnormal lipid buildup within hepatocytes, leading to inflammation and liver injury. Hepatic lipid ...
CRISPR/Cas9-Engineered HEK293T Cellular Model Harboring the Pathogenic CDKL5 c.172A>T Variant Recapitulates Core Molecular Phenotypes of CDKL5 Deficiency Disorder [0.03%]
具有致病性CDKL5 c.172A>T变异的CRISPR/Cas9工程HEK293T细胞模型再现了CDKL5缺陷症的核心分子表型
Fatemeh Faghihi,Jafar Amani,Milad Gholami et al.
Fatemeh Faghihi et al.
Background: Mutations in the CDKL5 gene are strongly associated with severe neurodevelopmental disorders, including atypical Rett syndrome and autism spectrum disorder (ASD). ...
In silico Identification of Natural Compounds as Potential TrkA Inhibitors for Anticancer Drug Development [0.03%]
计算识别天然化合物作为抗癌药物开发的潜在TrkA抑制剂
Mujtaba Fadhil,Dhurgham Al-Fahad,Faizul Azam et al.
Mujtaba Fadhil et al.
Background: Tropomyosin receptor tyrosine kinase A (TrkA) is essential for cancer cell migration and for stabilizing focal adhesions required for attachment to the extracellular matrix. However, resistance to inhibitors t...
Elucidating the Molecular Mechanisms of Angelica sinensis Against Hepatocellular Carcinoma Through Network Pharmacology, in silico Molecular Docking, and in vitro Validation [0.03%]
基于网络药理学、分子对接及体外试验阐明当归防治肝癌的分子机制研究
Huajun Wu,Ping Luo,Chongming Shen
Huajun Wu
Background: Hepatocellular carcinoma (HCC) is a lethal liver malignancy associated with substantial morbidity and mortality and remains a major socioeconomic burden worldwide. Given the high risk associated with HCC, nove...