The diagnostic and predictive value of miR-145-3p in gastric cancer and its regulation of gastric cancer progression via targeting CREB1 [0.03%]
miR-145-3p在胃癌诊断和预测中的价值及其通过靶向CREB1调控胃癌进展的作用研究
Kaitao Yao,Yan Zhu,Bing Zhang
Kaitao Yao
BackgroundGastric cancer (GC) is a highly prevalent malignant tumor worldwide. Traditional treatment approaches have numerous limitations, and messenger RNA (mRNA)-targeted therapy offers a new direction for the treatment of GC.ObjectiveTo ...
PFKP: A biomarker for prognosis, response to treatment and immune function of breast cancer [0.03%]
PFKP：一种乳腺癌预后、治疗反应和免疫功能的生物标志物
Katie-Rose Cawthorne,Alistair Heath,Vijay Sharma
Katie-Rose Cawthorne
BackgroundPhosphofructokinase-platelet (PFKP) is a rate-limiting enzyme in glycolysis. PFKP is highly expressed across many cancer types including breast cancer.PurposeTo assess the extent to which PFKP can be a prognostic indicator in brea...
Luminex assay of plasma IL-6, TNF-α, leptin, and adiponectin: Impact of anticoagulants, single-well analysis, and freeze-thaw stability [0.03%]
血浆IL-6、TNF-α、leptin和adiponectin Luminex检测试验：抗凝剂、单管分析及冻融稳定性的影响
Lara Pattaroni,Elisabetta Venturelli,Daniele Morelli et al.
Lara Pattaroni et al.
BackgroundChronic inflammation from visceral obesity contributes to metabolic disorders and cancer through cytokine imbalance. Accurate cytokine measurement is crucial to understand these links. This study examined challenges in quantifying...
Association of NF-kappaBIA rs696 gene polymorphism with breast cancer risk in Bangladeshi women: A case-control study [0.03%]
NF-κBIA基因多态性与孟加拉国妇女乳腺癌风险相关性的病例对照研究
Sara Shahid Meem,Sakif Ahamed Khan,Mohiuddin Ahmed Bhuiyan et al.
Sara Shahid Meem et al.
BackgroundBreast cancer is the leading cause of cancer-related mortality among women in developing nations. NFKBIA encodes the inhibitors of nuclear factor-kappaB (NF-κB), which plays a critical role in modulating inflammation and carcinog...
Circulating tumor cells and tumor-derived cell-free DNA in cancer management: Clinical evidence, limitations, and future directions [0.03%]
循环肿瘤细胞和肿瘤来源的胞外DNA在癌症治疗中的应用：临床证据、局限性及未来发展方向
Quratulain Maqsood,Attiqa Anwar,Aniqa Karim et al.
Quratulain Maqsood et al.
Liquid biopsy has emerged as a powerful approach for non-invasive cancer monitoring, with circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) representing biologically distinct yet complementary analytes. Cell-free DNA (cfDNA) ...
Exploring key biomarkers associated with axillary lymph node metastasis in breast cancer using single-cell RNA sequencing and Mendelian randomization [0.03%]
利用单细胞RNA测序和孟德尔随机化研究乳腺癌腋窝淋巴结转移相关的关键生物标志物
Limeng Qu,Jinyang Li,Shirong Ding et al.
Limeng Qu et al.
BackgroundAxillary lymph node metastasis (ALNM) serves as a critical prognostic determinant in breast cancer, yet the molecular drivers governing lymphatic dissemination remain poorly characterized. Integrating single-cell transcriptomic pr...
Circulating tumor DNA: An alternative to tissue biopsy for detecting epidermal growth factor receptor mutation in non-small cell lung cancer [0.03%]
循环肿瘤DNA检测表皮生长因子受体突变与非小细胞肺癌组织活检的比较研究
Md Kabirul Islam Soroar,Sharmistha Roy,Hosne Ara et al.
Md Kabirul Islam Soroar et al.
BackgroundNon-small cell lung cancer (NSCLC) patients who have mutations in their epidermal growth factor receptor (EGFR) gene respond more favorably to tyrosine kinase inhibitors (TKIs) than to standard chemotherapy. However, tissue biopsy...
Single-cell RNA sequencing analysis reveals cellular heterogeneity and immune microenvironment dynamics in colorectal cancer [0.03%]
单细胞RNA测序揭示结直肠癌的细胞异质性和免疫微环境动力学
Jin-Liang Zhu,Hong-Jian Gao,Lu-Ji Qiao et al.
Jin-Liang Zhu et al.
BackgroundDespite treatment advances, prognoses of patients with advanced colorectal cancer remain poor. The limited effectiveness of programmed cell death protein 1 (PD-1) blockade immunotherapy in a subset of patients necessitates a deepe...
BDH1 drives ovarian cancer progression by regulating cell cycling and stemness maintenance through Wnt/β-catenin signaling [0.03%]
BDH1通过Wnt/β-连环蛋白信号调节细胞周期和干细胞维持驱动卵巢癌进展
Shujing Sun,Lianghui Guo,Huili Zhu
Shujing Sun
BackgroundOvarian cancer is a lethal malignancy with limited therapeutic options, highlighting the urgent need to identify reliable biomarkers and therapeutic targets. This study investigates the clinical and oncogenic significance of β-hy...