Association of NF-kappaBIA rs696 gene polymorphism with breast cancer risk in Bangladeshi women: A case-control study [0.03%]
NF-κBIA基因多态性与孟加拉国妇女乳腺癌风险相关性的病例对照研究
Sara Shahid Meem,Sakif Ahamed Khan,Mohiuddin Ahmed Bhuiyan et al.
Sara Shahid Meem et al.
BackgroundBreast cancer is the leading cause of cancer-related mortality among women in developing nations. NFKBIA encodes the inhibitors of nuclear factor-kappaB (NF-κB), which plays a critical role in modulating inflammation and carcinog...
Circulating tumor cells and tumor-derived cell-free DNA in cancer management: Clinical evidence, limitations, and future directions [0.03%]
循环肿瘤细胞和肿瘤来源的胞外DNA在癌症治疗中的应用：临床证据、局限性及未来发展方向
Quratulain Maqsood,Attiqa Anwar,Aniqa Karim et al.
Quratulain Maqsood et al.
Liquid biopsy has emerged as a powerful approach for non-invasive cancer monitoring, with circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) representing biologically distinct yet complementary analytes. Cell-free DNA (cfDNA) ...
Exploring key biomarkers associated with axillary lymph node metastasis in breast cancer using single-cell RNA sequencing and Mendelian randomization [0.03%]
利用单细胞RNA测序和孟德尔随机化研究乳腺癌腋窝淋巴结转移相关的关键生物标志物
Limeng Qu,Jinyang Li,Shirong Ding et al.
Limeng Qu et al.
BackgroundAxillary lymph node metastasis (ALNM) serves as a critical prognostic determinant in breast cancer, yet the molecular drivers governing lymphatic dissemination remain poorly characterized. Integrating single-cell transcriptomic pr...
Circulating tumor DNA: An alternative to tissue biopsy for detecting epidermal growth factor receptor mutation in non-small cell lung cancer [0.03%]
循环肿瘤DNA检测表皮生长因子受体突变与非小细胞肺癌组织活检的比较研究
Md Kabirul Islam Soroar,Sharmistha Roy,Hosne Ara et al.
Md Kabirul Islam Soroar et al.
BackgroundNon-small cell lung cancer (NSCLC) patients who have mutations in their epidermal growth factor receptor (EGFR) gene respond more favorably to tyrosine kinase inhibitors (TKIs) than to standard chemotherapy. However, tissue biopsy...
Single-cell RNA sequencing analysis reveals cellular heterogeneity and immune microenvironment dynamics in colorectal cancer [0.03%]
单细胞RNA测序揭示结直肠癌的细胞异质性和免疫微环境动力学
Jin-Liang Zhu,Hong-Jian Gao,Lu-Ji Qiao et al.
Jin-Liang Zhu et al.
BackgroundDespite treatment advances, prognoses of patients with advanced colorectal cancer remain poor. The limited effectiveness of programmed cell death protein 1 (PD-1) blockade immunotherapy in a subset of patients necessitates a deepe...
BDH1 drives ovarian cancer progression by regulating cell cycling and stemness maintenance through Wnt/β-catenin signaling [0.03%]
BDH1通过Wnt/β-连环蛋白信号调节细胞周期和干细胞维持驱动卵巢癌进展
Shujing Sun,Lianghui Guo,Huili Zhu
Shujing Sun
BackgroundOvarian cancer is a lethal malignancy with limited therapeutic options, highlighting the urgent need to identify reliable biomarkers and therapeutic targets. This study investigates the clinical and oncogenic significance of β-hy...
Phosphorylated DHX9 inhibited the progression of lung adenocarcinoma by regulating R-loops mediated DNA damage [0.03%]
磷酸化DHX9通过调节R-loop介导的DNA损伤抑制肺腺癌进展
Lei Wu,Shengyu Wang,Xin Diao et al.
Lei Wu et al.
ObjectivesWe investigated the interactions among DHX9, phosphorylated DHX9, R-loops, and DNA damage to clarify the mechanism by which phosphorylated DHX9 inhibited lung adenocarcinoma progression.MethodsUsed PC-9 and 2BS cells divided into ...
HPV-positive head and neck squamous cell carcinoma: From molecular pathogenesis to therapeutic frontiers [0.03%]
人乳头瘤病毒阳性头颈鳞癌：从分子发病机制到治疗进展
Ying Li,Shengfei Zhou
Ying Li
The global incidence of human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) has increased markedly over recent decades, leading to a fundamental shift in the epidemiology and clinical management of head and nec...
Meta-analytic and systematic review of the diagnostic value of DNA methylation-based biomarkers in cervical cancer [0.03%]
基于DNA甲基化标志物的宫颈癌诊断价值的荟萃分析和系统评价
Hue Hong Thieu,Thuy Ai Huyen Le,Thuan Duc Lao
Hue Hong Thieu
IntroductionCervical cancer represents a significant global health problem, ranking as the fourth most prevalent malignant cancer in women, particularly in low- and middle-income countries. Epigenetic silencing via aberrant methylation of t...