Effect of metreleptin treatment in congenital generalized lipodystrophy: a retrospective analysis from the MENA region [0.03%]
MENA地区先天性全身性脂代谢障碍患者的美尔特佩汀治疗效果回顾性分析
Majid Alfadhel,Afaf Alsagheir,Azza Al Shidhani et al.
Majid Alfadhel et al.
Purpose: Congenital generalized lipodystrophy (CGL) is characterized by near-total loss of body fat, leptin deficiency, and severe metabolic complications. Clinical data show that metreleptin improves metabolic control in...
Oral polychemotherapy to induce remission in newly diagnosed type 2 diabetes: results from a randomized controlled trial [0.03%]
新诊断的2型糖尿病诱导缓解的口服药物化疗：一项随机对照试验的结果
Alessandra Dei Cas,Raffaella Aldigeri,Giuseppe Maglietta et al.
Alessandra Dei Cas et al.
Purpose: To assess the efficacy of a four-drug regimen (POLYCHEM) vs. standard diabetes care (SDC) in inducing remission in patients with newly diagnosed type 2 diabetes. ...
Chronic kidney disease: from mineral dysregulation to bone and cardiovascular disease [0.03%]
慢性肾病：从矿质失衡到骨和心血管疾病
Melpomeni Moustaki,Stavroula A Paschou,Eleni Palioura et al.
Melpomeni Moustaki et al.
Background: Chronic kidney disease-mineral bone disorder (CKD-MBD) concerns more than 50% of patients with moderate/severe CKD, increasing their risk for fractures and cardiovascular events. ...
Evaluation of aquaporin-7, adiponectin, and TNF-α levels in obese children [0.03%]
评估肥胖儿童Aquaporin-7、脂联素和TNF-α水平的影响
Emine Yurdakul Erturk,Arzu Sahin Berberoglu,Songul Doganay
Emine Yurdakul Erturk
Purpose: This study aimed to determine serum levels of aquaporin-7 (AQP7), adiponectin (ADPN), and tumor necrosis factor-alpha (TNF-α) and to investigate their associations with metabolic parameters in children with obes...
Osteoprotegerin is strongly associated with calcium and magnesium in seminal fluid but not affected by denosumab [0.03%]
骨保护素与精液中的钙和镁密切相关，但不受地诺单抗的影响
Sam Kafai Yahyavi,Mads Joon Jorsal,Emil Brink Wriedt et al.
Sam Kafai Yahyavi et al.
Objective: While the effect of the RANKL-inhibitor denosumab on serum minerals is well-documented, its impact on seminal fluid minerals is poorly understood. This study examines the correlation between the high levels of ...
Advances in proteomics research related to semaglutide: evidence from humans and animals [0.03%]
司美格鲁肽相关蛋白质组学研究进展：人和动物证据显示的一致性与差异性
Qiannan Jia,Hua Mu,Yuqing Wang et al.
Qiannan Jia et al.
Background: With the advancement of proteomics technologies, an increasing number of studies have begun to examine semaglutide-associated protein expression changes and pathway alterations across different biological cont...
Longitudinal trends in general, central, and visceral adiposity indices among women with endometriosis: a population-based study [0.03%]
基于人群的队列研究：子宫内膜异位症女性总体肥胖、中心型肥胖和腹腔内脂肪量纵向趋势分析
Mahbanoo Farhadi-Azar,Marzieh Saei Ghare Naz,Maryam Mousavi et al.
Mahbanoo Farhadi-Azar et al.
Background: Previous studies have suggested the close link between endometriosis and body size index. However, there are inconsistent associations between central, general, and visceral adiposity index and endometriosis. ...
Beyond monogenic obesity: the unmet need for anti-obesity pharmacotherapy in rare genetic syndromes [0.03%]
超越单基因型肥胖：罕见遗传综合征抗肥胖药物治疗的未满足需求
Angelo Di Vincenzo,Marnie Granzotto,Elisabetta Trevellin et al.
Angelo Di Vincenzo et al.
The advent of highly effective anti-obesity pharmacotherapy has transformed obesity management, yet patients with rare genetic syndromes associated with obesity remain largely excluded from evidence generation and clinical guidance. Conditi...
Regional adipose tissue redistribution and infiltration in primary osteoporosis: A comprehensive body composition study [0.03%]
原发性骨质疏松的区域脂肪组织重新分布和侵润：一项全面的身体成分研究
Zixiang Geng,Long Yuan,Ning Wang et al.
Zixiang Geng et al.
Background: Primary osteoporosis (OP) has traditionally been viewed as a skeletal disorder; however, its complex interactions with muscle and adipose tissue are increasingly recognized. Nevertheless, the specific characte...
Molecular and immunohistochemical characterization of cribriform-morular thyroid carcinoma: insights into its origin and therapeutic targets [0.03%]
筛孔-肌样甲状腺癌的分子和免疫组化特征：起源及治疗靶点的新认识
Joo Yeon Koo,Ji Young Lee,Nah Ihm Kim et al.
Joo Yeon Koo et al.
Background: Cribriform-morular thyroid carcinoma (CMTC) is a rare thyroid malignancy with distinctive morphology that occurs sporadically or in association with familial adenomatous polyposis. Despite known WNT/β-catenin...