Interpreting the GnRH stimulation test in girls with central precocious puberty: the role of age and body mass index [0.03%]
中枢性青春期早熟女童GnRHa激发试验的解读：年龄和体重指数的影响分析
Selen Hürmüzlü Közler,Fatih Kilci,Emre Sarıkaya et al.
Selen Hürmüzlü Közler et al.
Purpose: The gonadotropin-releasing hormone (GnRH) stimulation test is the reference standard for diagnosing central precocious puberty (CPP), yet its reliability may vary with age and body mass index (BMI). This study ev...
Lifelong congenital untreated isolated GH deficiency does not alter human leukocyte telomere length [0.03%]
终身先天性未经治疗的孤立性生长激素缺乏症不影响人类白细胞端粒长度
Ângela C Leal,Rodrigo T Calado,Martin Bidlingmaier et al.
Ângela C Leal et al.
Background: Telomere shortening reflects cumulative cell replication and functions as a mitotic clock. It is influenced by age and body mass, as both increase the demand for cell proliferation. The GH/IGF-I axis plays a c...
Prospective changes in sleep quality and depressive symptom burden following initiation of GLP-1-based therapies in patients with obesity: a real-world study [0.03%]
肥胖患者启动基于GLP-1的治疗后睡眠质量和抑郁症状负担的变化：一项真实世界研究
Yusuf Kır,Cem Haymana,Bora Toros et al.
Yusuf Kır et al.
Purpose: This study aimed to evaluate short-term changes in depressive symptom burden and sleep quality and factors associated with clinical response in patients with obesity initiating GLP-1-based therapies. ...
Preimplantation genetic testing for male factor infertility: lights and shadows [0.03%]
胚胎植入前男性因素不孕遗传学检测的利与弊
Rossella Mazzilli,Danilo Cimadomo,Antonio Capalbo et al.
Rossella Mazzilli et al.
Background: Male factor could contribute, alone or in combination with female factor, to the inability to conceive in a couple in more than half of cases. The effect of male factor infertility (MFI) on embryological assis...
Functional analysis of 11 CYP21A2 variants reveals greater loss of enzyme activity in cis variants and improves genotype-phenotype correlation in 21-hydroxylase deficiency [0.03%]
11个CYP21A2变异体的功能分析表明顺式变异体的酶活性更大程度的丧失并可改善21-羟化酶缺乏症基因型-表型关联
Chenjie Guo,Xiaoxia Zhang,Lin Lu et al.
Chenjie Guo et al.
Purpose: Clinical severity of 21-hydroxylase deficiency (21-OHD) is primarily determined by the CYP21A2 genotype and residual enzymatic activity of mutant CYP21A2. However, CYP21A2 variants often lack functional character...
Functional hyperprolactinemia and subclinical primary hypothyroidism: myth or reality in clinical practice? [0.03%]
功能性高催乳素血症和亚临床原发性甲状腺功能减退症：临床实践中的神话还是现实？
Giulia Bovo,Pierluigi Mazzeo,Giorgia Antonelli et al.
Giulia Bovo et al.
Background: Hyperprolactinemia is a frequent clinical condition with different etiologies. Although primary hypothyroidism is often considered a leading cause of mild hyperprolactinemia, the supporting evidence is limited...
Total thyroidectomy versus limited thyroidectomy for isthmic papillary thyroid carcinoma: a systematic review and meta-analysis of oncologic outcomes and surgical morbidity [0.03%]
甲状腺峡部乳头状癌的全切除术与有限切除术的系统评价和荟萃分析：肿瘤学结局及手术并发症分析
Ziliang Ding,Yukun Wei,Xiaoxiao Yao et al.
Ziliang Ding et al.
Background: The optimal surgery for isthmic papillary thyroid carcinoma (IPTC) remains controversial. This meta-analysis compared oncologic and complication outcomes between total (TT) and limited thyroidectomy (LT). ...
Heme oxygenase-1 in thyroid cancer: a context-dependent regulator [0.03%]
甲状腺癌中的血红素氧合酶-1：一种依赖环境的调节因子
Exequiel Gonzalo Alonso,Marilina Mascaró,Karen Schweitzer et al.
Exequiel Gonzalo Alonso et al.
Purpose: Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step of heme degradation and has traditionally been regarded as a cytoprotective, antioxidant enzyme. However, HO-1 also influences tumour behaviour through act...
Hyperglycemia during ICI Therapy: etiology, risk factors, and survival outcome [0.03%]
ICI治疗期间的高血糖：病因、危险因素及生存结局
Min Shen,Xinpan Wang,Tianyu Gao et al.
Min Shen et al.
Background: The spectrum of hyperglycemia and its association with overall survival (OS) in patients receiving immune checkpoint inhibitors (ICIs) are not characterized. ...
Early integrated management and characteristics of adult patients with overweight and obesity: a modified delphi consensus study in Italy [0.03%]
意大利成人超重和肥胖综合管理的早期干预及特点：改良德尔菲共识研究
Valeria Guglielmi,Giuseppe Musumeci,Carlotta Galeone et al.
Valeria Guglielmi et al.
Purpose: A comprehensive approach to the management of obesity, considering its complications besides the disease itself, may be advantageous, and effective obesity medications are now available. Several aspects of the in...