Interleukin-1β Gene (IL-1B) rs16944 (-511 C > T) Promoter Polymorphism Is Associated with Cutaneous Melanoma Susceptibility, Stage, and Anatomical Localization in a Northern Italian Case-Control Study [0.03%]
白细胞介素-1基因（IL-1B）rs16944（-511C＞T）启动子多态性与北部意大利色素瘤病例对照研究中皮肤黑色素瘤的易感性、分期及解剖部位有关
Sabina Cauci,Cinzia Buligan,Patrizia Nacci et al.
Sabina Cauci et al.
Immunity plays critical roles in cutaneous melanoma. We investigated the association between the pro-inflammatory interleukin-1β gene (IL-1B) rs16944 (-511 C > T) promoter single nucleotide polymorphism (SNP) and cutaneous melanoma suscept...
Transcriptomic Stratification Reveals an FRS2-Associated, Proliferation-Independent Phenotype in MDM2-High Sarcomas [0.03%]
转录组谱系分析揭示了MDM2高表达的肉瘤中与FRS2相关且独立于增殖的表型
Takao Sakai,Hisaki Aiba,Makoto Yamaguchi et al.
Takao Sakai et al.
Sarcomas with Murine Double Minute 2 (MDM2) amplification are considered potential candidates for MDM2-targeted therapy. However, the limited efficacy of MDM2 inhibitor monotherapy suggests that additional biological factors may influence t...
Report from the 27th Annual Western Canadian Gastrointestinal Cancer Consensus Conference on Colorectal Cancer, Calgary, Alberta, 26-27 September 2025: Advances in Colon and Rectal Cancer [0.03%]
2025年9月26日至27日在阿尔伯塔省卡尔加里举行的第27届加拿大西部胃肠癌症共识会议结直肠癌专题报告：结肠和直肠癌的新进展
Richard Lee-Ying,Sharlene Gill,Adrian Box et al.
Richard Lee-Ying et al.
The 27th annual Western Canadian Gastrointestinal Cancer Consensus Conference (WCGCCC) was held in Calgary, Alberta, on 26-27 September 2025. The WCGCCC is an interactive multidisciplinary conference that was attended by healthcare professi...
Real-World Outcomes of Frontline Multimodal Treatment Strategies for Localized Extranodal NK/T-Cell Lymphoma, Nasal Type: A Single-Center Vietnamese Cohort Study [0.03%]
一线多模式治疗方案对局部鼻型外周T细胞淋巴瘤的现实世界疗效：单一中心越南队列研究
Huong Nguyen Thi Thu,Dang Nguyen Van,Yen Le Thi et al.
Huong Nguyen Thi Thu et al.
Introduction: Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL-NT), is a rare and aggressive lymphoma for which real-world data from resource-limited settings remain scarce. This study evaluated the efficacy a...
Przemysław Dybcio,Anna Kuraś,Mikołaj Dyrka et al.
Przemysław Dybcio et al.
Perineural invasion (PNI) is a distinct route of cancer spread associated with neuropathic pain, local recurrence, and poor survival across many solid tumours. Increasing evidence shows that PNI is not only a structural pattern of invasion ...
An Equity-Embedded, Protocol-Agnostic Pre-Trial Navigation Model for Canadian Blood Cancer Trials: Findings from the Myeloma Canada Phase 0 Workshop [0.03%]
加拿大血癌临床试验的股权嵌入式、协议不可知的庭前导航模型：来自Myeloma CanadaPhase 0研讨会的结果
Gabriele Colasurdo,Alvina Nadeem,Nina Mason et al.
Gabriele Colasurdo et al.
Background: Inequitable access to clinical trials persists in blood cancers despite ongoing equity, diversity, and inclusion (EDI) efforts. Despite the critical role of clinical trials in improving survival and outcomes, recruitment remains...
Early Adherence to Immunomodulators in Multiple Myeloma: Retrospective Observations from a Safety-Net Hospital [0.03%]
来自安全网医院的多发性骨髓瘤患者使用免疫调节药物早期依从性的回顾性观察
Onyebuchi Ononogbu,Sydney Mohr,Javeria Khalid et al.
Onyebuchi Ononogbu et al.
Background/Objectives: Multiple myeloma (MM) disproportionately affects older adults and racial/ethnic minorities, many of whom face socioeconomic barriers to care. Immunomodulators (IMiDs) are central to MM therapy, but their benefit relie...
Controversies in the Management of AML in Older Patients: A Canadian Perspective [0.03%]
老年AML患者治疗中的争议问题——加拿大视角
Andre C Schuh,Joseph Brandwein,Mahmoud Elsawy et al.
Andre C Schuh et al.
In the companion article in this issue of Current Oncology, 'Management of AML in Older Patients: An Updated Canadian Consensus', the authors have presented the third iteration of Canadian consensus guidelines on AML treatment in the elderl...
Substantial LVSI Is Independently Associated with Para-Aortic Nodal Metastasis in Patients Undergoing Laparoscopic Surgical Staging for Endometrial Cancer [0.03%]
显著的LVSI与子宫内膜癌腹腔镜手术期盆腔淋巴结转移独立相关
Candost Hanedan,Oğuz Kaan Köksal,Şahin Kaan Baydemir et al.
Candost Hanedan et al.
Lymphovascular space invasion (LVSI) is a well-established prognostic factor in endometrial cancer; however, its independent contribution to para-aortic nodal metastasis remains incompletely defined. Identifying factors associated with noda...
Management of Acute Myeloid Leukemia in Older Patients: An Updated Canadian Consensus [0.03%]
老年急性髓系白血病患者管理：加拿大共识更新
Andre C Schuh,Nicholas Chornenki,Mohamed A Elemary et al.
Andre C Schuh et al.
These are the third Canadian consensus guidelines on the management of acute myeloid leukemia (AML) in older patients. The first was published in 2013, and the second in 2017. The management of AML in older patients changed significantly ov...