Urolithin A mitigates doxorubicin-induced myocardial injury via suppression of ROS-driven apoptotic signaling [0.03%]
富角豆胶苹果渣通过抑制ROS驱动的凋亡信号减轻多柔比星诱导的心肌损伤
Wei Song,Mei Chen,Lin Pang et al.
Wei Song et al.
Background: Doxorubicin (DOX), as a broad-spectrum antitumor drug, achieved great success in the clinic. Nevertheless, severe adverse effects, in particular cardiac toxicity, significantly restrict its clinical utilizatio...
Application of the ultrasonic oscillation flotation method in paraffin section preparation [0.03%]
超声振荡浮选法在石蜡切片制备中的应用研究进展
Min Zhang,Yue Chen,Lü Ren et al.
Min Zhang et al.
Objective: To enhance the quality and efficiency of paraffin-embedded pathological section preparation, this study aims to investigate the potential benefits of utilizing the ultrasound oscillation flotation method (UOFM)...
Protective effects of Abelmoschus manihot flower extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vivo and in vitro [0.03%]
Hibiscus manihot花提取物对LED蓝光损伤视网膜感光细胞的体内外保护作用
Li Ling Wu,Szu-Yu Lung,Wei-Hao Peng
Li Ling Wu
Background: Excessive exposure to blue light (BL) from light-emitting diodes (LEDs) induces oxidative stress and photoreceptor degeneration, contributing to retinal damage. Abelmoschus manihot flower extract (AME), rich i...
Advances and challenges in developing expandable human hepatocytes for regenerative medicine [0.03%]
用于再生医学的可扩展人肝细胞的研发进展与挑战
Saaya Yamane,Masaki Nishikawa,Yasuyuki Sakai et al.
Saaya Yamane et al.
Liver transplantation remains the only effective treatment for severe liver disease, but donor shortages pose a serious challenge, underscoring the need for alternative therapeutic strategies. Hepatocyte transplantation has been proposed as...
Acupuncture alleviates the progression of lumbar disc herniation by regulating the autophagy level of nucleus pulposus cells through the SIRT1/Sestrin2 pathway [0.03%]
针刺通过SIRT1/Sestrin2信号通路调节椎间盘髓核细胞自噬水平缓解腰椎间盘突出症的发展进展
Xiaoyan Wang,Jia Lu,Pengyue Zhang et al.
Xiaoyan Wang et al.
Background and purpose: Lumbar disc herniation (LDH) is a degenerative spine disease and the most common cause of lower back pain, with a high prevalence in younger patients. The use of acupuncture (AC) as a conservative ...
Nicotinamide adenine dinucleotide phosphate hydrogen oxidase 2 exacerbates abdominal aortic aneurysm formation by inducing oxidative stress through autophagy inhibition [0.03%]
NADPH氧化酶2通过抑制自噬诱导氧化应激促进腹主动脉瘤形成
Xiaoliang Yin,Dehai Lang,Songjie Hu
Xiaoliang Yin
Abdominal aortic aneurysm (AAA) has high mortality and enhanced oxidative stress; autophagy inhibition accelerates its formation. Nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase 2 (NOX2) is responsible for generating re...
Immunohistological parathormone production changes and angiogenesis in normal and adenomatous human parathyroid glands [0.03%]
正常和腺瘤性人甲状旁腺的免疫组化甲状旁腺激素生成变化及血管发生现象
Teruyuki Sato,Yutaka Tateda,Kazue Ise et al.
Teruyuki Sato et al.
Introduction: Parathyroid tumor function is not always positively correlated with tumor size, complicating the disease picture. Here, we compared parathormone (PTH) and vascular endothelial growth factor (VEGF)-A expressi...
Beyond cytoskeletal regulation: Rho-associated, coiled-coil containing protein kinase 2 in kidney inflammation and fibrosis [0.03%]
超越细胞骨架调节：Rho相关卷曲螺旋蛋白激酶2在肾脏炎症和纤维化中的作用
Keiichiro Matoba
Keiichiro Matoba
Chronic kidney disease (CKD), histologically defined by glomerulosclerosis, tubular atrophy, interstitial fibrosis, and capillary rarefaction, represents a profound challenge in cellular pathology. This review synthesizes recent advances to...
Prognostic significance of ACADL and MCM2 in meningiomas: Current evidence and clinical implications [0.03%]
ACADL和MCM2在脑膜瘤中的预后意义：现有证据及临床意义
Alberto Pietrantoni,Fabio Agistri,Valeria Barresi
Alberto Pietrantoni
This review summarizes the current evidence on the expression and prognostic significance of acyl-CoA dehydrogenase long-chain (ACADL) and minichromosome maintenance 2 (MCM2) in meningiomas. Meningiomas, which comprise approximately 41% of ...
Aldose reductase as a regulator of ocular pathology: Mechanisms and therapeutic potential [0.03%]
醛糖还原酶作为眼病的调节因子：机制及治疗潜力
Laman Mirzaliyeva,Pei-Kang Liu,Dimitrios Stavropoulos et al.
Laman Mirzaliyeva et al.
Aldose reductase (AR), the rate-limiting enzyme of the polyol pathway, converts glucose to sorbitol using NADPH and becomes markedly overactive under hyperglycemic conditions. Its widespread expression in ocular tissues links AR to numerous...