Caloric restriction attenuates age-related liver and kidney alterations in mice: Histological evidence [0.03%]
热量限制可减轻小鼠肝脏和肾脏的年龄相关变化：组织学证据
Carlos R Montes-de-Oca-Saucedo,Sheila A Villa-Cedillo,Cristina S Ríos-Vázquez et al.
Carlos R Montes-de-Oca-Saucedo et al.
Objective: This study evaluated the histological impact of long-term caloric restriction (CR) on liver and kidney aging, assessing fibrosis, metabolic overload, and senescence-associated readouts. ...
Peptidoglycan recognition proteins in the brain: Role in neuroinflammation and behavioral consequences [0.03%]
脑肽聚糖识别蛋白在神经炎症和行为后果中的作用
Kyoungho Suk,Won-Ha Lee
Kyoungho Suk
Peptidoglycan recognition proteins (PGRPs) constitute an evolutionarily conserved family of pattern recognition molecules that detect bacterial peptidoglycan. While their antimicrobial functions have been well characterized in peripheral im...
Contrasting roles of PD-L1 expression in tumor and stroma: Biological and prognostic implications in esophageal squamous cell carcinoma [0.03%]
肿瘤和间质中PD-L1表达的作用对比及其在食管鳞癌中的生物和预后意义
Eisuke Booka,Tomohiro Murakami,Hiroya Takeuchi
Eisuke Booka
Programmed death-ligand 1 (PD-L1) plays a central role in immune regulation in esophageal squamous cell carcinoma (ESCC) and has been widely used as a biomarker for immune checkpoint inhibitor therapy. However, the biological and clinical s...
Do patterns of perineural invasion improve risk stratification in prostate cancer? A narrative review [0.03%]
前列腺癌中周围神经侵犯的模式能改善风险分层吗？综述
Hiroshi Miyamoto
Hiroshi Miyamoto
The presence of perineural invasion (PNI), typically defined as direct contact between cancer cells and nerves, is a well-established adverse prognostic factor following definitive treatment when identified on prostate needle core biopsy. I...
Approach and nomenclature problems of extracutaneous basaloid neoplasias of visceral organs with three cases of basaloid carcinoma described for the first time in the urinary bladder [0.03%]
器官粘膜的基底样肿瘤的命名及诊断问题并首次报道3例尿路上皮基底样癌
Yeşim Sağlıcan,Yaşar Ünlü,Kemal Behzatoğlu
Yeşim Sağlıcan
Pure basal cell carcinomas/basaloid carcinomas (BCC/BC) from only basal cells in the urinary bladder have not been reported so far. Our aim in this study was to present three BC cases showing distinct pilomatrixoma-like keratinization (matr...
Artificial intelligence for detection, grading, and prognostication in prostate cancer pathology: A scoping review [0.03%]
前列腺癌病理检测、分级和预后的人工智能应用：系统综述
Ranjitha Pratap Nair,Wei Du,Lin Mei et al.
Ranjitha Pratap Nair et al.
Artificial intelligence (AI) has been transforming many aspects of medical care. In prostate cancer, ongoing progress in AI has improved research and patient care. Recent advances in machine learning and deep learning have produced tools th...
Inverted urothelial papilloma: Diagnostic challenges, molecular insights, and clinical implications [0.03%]
尿路上皮乳头状瘤的诊断挑战、分子见解及临床意义
Keiichiro Kitahama,Kentaro Inamura
Keiichiro Kitahama
Inverted urothelial papilloma (IUP) is a rare benign tumor of the urinary tract, most commonly arising in the bladder and characterized by an endophytic growth pattern. IUP primarily affects middle-aged and older men and typically presents ...
The protective role of FLI-1 in cardiac hypertrophy: Modulation of the IGF-1R/GNAI1/PLCG1 pathway [0.03%]
FLI-1在心脏肥厚中的保护作用：调节IGF-1R/GNAI1/PLCG1通路
Gang Tang,Yunlong Li,Weiwei Wang et al.
Gang Tang et al.
The transcription factor Friend leukemia integration-1 (FLI-1) is implicated in various cellular functions, including the regulation of cardiovascular function. This study aimed to elucidate the role and molecular mechanisms of FLI-1 in myo...
RRM2/GCH1 signaling decreased cisplatin sensitivity in cervical cancer by modulating the ferroptosis process [0.03%]
RRM2/GCH1信号通过调节铁死亡过程降低宫颈癌细胞对顺铂的敏感性
Jin Zhao,Linlin Wang,Ning Shao et al.
Jin Zhao et al.
Background: Cisplatin-based chemotherapy serves as a fundamental approach in the treatment of cervical cancer; however, its effectiveness is often hindered by the development of drug resistance, which presents a significa...
Mechanism and experimental validation of a network pharmacology-based approach of Huoluo Yinao formula in treating chronic cerebral hypoperfusion [0.03%]
基于网络药理学的活络益脑膏治疗慢性脑低灌注的作用机制及实验验证
Song Yang,Junpeng Li,Wen Nie et al.
Song Yang et al.
Chronic cerebral hypoperfusion (CCH) is a cerebral dysfunction caused by insufficient cerebral perfusion, and Huoluo Yinao (HLYN) formula is a traditional Chinese medicinal formula used for CCH treatment. We investigated the specific mechan...