How short and dense are axonal microtubules? Approaches for analyzing microtubule organization and dynamics [0.03%]
轴突微管有多短且密集？分析微管组织和动态的方法
Lisha Singh,Laryssa Alves Borba,Kim Stuke et al.
Lisha Singh et al.
Axons are cable-like extensions of neurons that conduct nerve impulses and relay information to subsequent cells at synapses. Their length varies dramatically, from micrometers in small invertebrates to over a meter in some neurons of large...
Electroacupuncture alleviates cerebral ischemia injury by promoting microglial polarization and inhibiting inflammation in MCAO rats [0.03%]
电针通过促进小胶质细胞极化和抑制炎症减轻永久性脑缺血损伤
Dan Lu,Yizhou Shou,Jiankai Mao et al.
Dan Lu et al.
Background: Electroacupuncture (EA), a Chinese traditional medicine, has a protective effect on cerebral ischemic injury. However, the mechanism underlying its effect is still unclear. In this study, we assessed whether E...
Application of single-cell transcriptomic technology in cell fate determination of embryonic liver [0.03%]
单细胞转录组技术在胚胎期肝脏细胞命运决定中的应用研究进展
Chenhao Wang,Xuejia Zheng,Feng Zhu et al.
Chenhao Wang et al.
Single-cell transcriptomics has revolutionized our understanding of embryonic liver development by enabling high-resolution dissection of lineage specification and cellular interactions. In this review, we synthesize recent advances from sc...
The role and mechanism of ZBP1 in the occurrence and development of systemic inflammation [0.03%]
ZBP1在系统性炎症发生发展中的作用及机制研究
Yifang Xiao,Li&#x;an Bai,Zhongyuan Zhan et al.
Yifang Xiao et al.
This review aims to comprehensively summarize the roles and underlying mechanisms of Z-DNA-binding protein 1 (ZBP1) in the onset and progression of systemic inflammation. As a critical initiator of PANoptosis and a sensor of Z-nucleic acids...
Mixed/combined pulmonary non-small cell carcinoma and carcinoid: State-of-the-Art review of clinical, histological, and molecular features with therapeutic implications [0.03%]
混合型/结合型肺非小细胞癌和类癌：临床、组织病理及分子特征的现状评价及其对治疗的影响
Paola Parente,Luisella Righi,Marco Donatello Delcuratolo et al.
Paola Parente et al.
Mixed neuroendocrine-non-neuroendocrine neoplasms are well-known entities and are codified as separate classes in the WHO classification of different organs and systems. In particular, combined low-grade neuroendocrine neoplasms-such as neu...
Electroacupuncture alleviates renal injury in hypertension by regulating the JAK2/STAT3 signaling pathway via m6A methylation of SOCS1 [0.03%]
电针通过调节SOCS1 mRNA的m6A甲基化激活JAK2/STAT3信号途径缓解高血压肾损伤
Jian Wen,Zifeng Dai,Yuting Wang et al.
Jian Wen et al.
Background: While electroacupuncture has been shown to improve renal injury associated with salt-sensitive hypertension, its mechanism of action requires elucidation. This study sought to elucidate the epigenetic regulati...
Curcumin enhances the protective effect of bone marrow mesenchymal stem cell-derived extracellular vesicles in alleviating intervertebral disc degeneration [0.03%]
姜黄素增强骨髓间充质干细胞源性外泌体对椎间盘退变的保护作用
Kai Chen,Sheng Mei,Pengli Zhang
Kai Chen
Background: Intervertebral disc degeneration (IVDD) is a major cause of chronic low back pain, with limited treatment options. Bone marrow mesenchymal stem cell-derived extracellular vesicles (BM-MSC-EVs, EVs) have shown ...
Morphological features of tip cells in corneal, retinal, and cho-roidal neovascularization in mice [0.03%]
小鼠角膜、视网膜和脉络膜新生血管尖细胞的形态特征研究
Hui Jiang,Chang Sik Cho,Jeong Hun Kim
Hui Jiang
In the current research, we used the techniques of DLL4/IB4/CD31/LYVE-1 im-munofluorescence (IF) staining and confocal microscopy to view the morphological features of tip cells in models of corneal, retinal, and choroidal neovascularizatio...
Beyond a passive coating: The cancer glycocalyx as a dynamic biophysical and immune interface [0.03%]
超越被动涂层：作为动态生物物理和免疫界面的癌症糖萼
Hiroyuki Tomita
Hiroyuki Tomita
The glycocalyx is a carbohydrate-rich layer formed by glycoproteins, glycolipids, proteoglycans, and glycosaminoglycans at the outer cell surface. In cancer, this layer is not a passive coating. Its thickness, composition, charge, and nanos...
Establishment of PDX/PDXO models to evaluate the antitumor efficacy and mechanism of Abemaciclib in gastric-type cervical cancer [0.03%]
建立Abemaciclib在胃型宫颈癌疗效及机制评估的PDX/PDXO模型
Quan He,Chen Yin,Jiaqi Mei et al.
Quan He et al.
Objective: This study aimed to evaluate the therapeutic efficacy of the CDK4/6 inhibitor abemaciclib in gastric-type cervical cancer (GAS) using patient-derived xenograft (PDX) and patient-derived xenograft organoid (PDXO...