Betulinic acid mitigates septic cardiomyopathy in mice through modulating the TLR4/MyD88/NF-κB signaling axis and NLRP3 inflammasome pathway [0.03%]
白桦脂酸通过调节TLR4/myd88/NF-κB信号轴和NLRP3炎性小体途径缓解小鼠脓毒症心肌病
Yanyan Tao,Xinning Xu,Jie Wang et al.
Yanyan Tao et al.
Background: Although betulinic acid (BA) possesses diverse pharmacological properties, its cardioprotective potential in sepsis-associated myocardial damage remains undefined. This investigation explores BA's therapeutic ...
Extension loss following ACL reconstruction: A narrative review of mechanisms and phase-specific management [0.03%]
ACL重建后的伸长损失：机制和分期特异性管理的叙述性综述
Akinori Kaneguchi
Akinori Kaneguchi
Extension loss is a prevalent and clinically debilitating complication following anterior cruciate ligament reconstruction (ACLR). Joint immobilization is widely recognized as a primary etiology of range of motion (ROM) restriction across v...
ShenQiWan alleviates chondrocyte pyroptosis in knee osteoarthritis by inhibiting the NF-κB/NLRP3 signaling pathway [0.03%]
Shenqiwan通过抑制NF-κB/NLRP3信号通路缓解膝骨关节炎软骨细胞焦亡
Yantao Zhu,Shan Xu,Guojun Wang et al.
Yantao Zhu et al.
Objectives: Knee osteoarthritis (KOA) is a progressive degenerative condition prevalent in older adults. ShenQiWan (SQW) has shown notable clinical efficacy in treating KOA. However, the role and mechanism of SQW in KOA a...
Transcription factor TFAP2A upregulates CDC6 to mediate glycolysis and promote stemness in lung adenocarcinoma cells [0.03%]
转录因子TFAP2A通过上调CDC6促进肺癌腺癌细胞糖酵解和干性形成
Hejian Chen,Xinju Wang
Hejian Chen
Background: Lung adenocarcinoma (LUAD) is a kind of lung cancer characterized by cancer stem cell (CSC) properties. Cell division cycle 6 (CDC6), a cell cycle regulator, is significantly associated with tumor progression,...
Knockdown of Slc11a1 alleviates myocardial ischemia reperfusion-induced injury in mice [0.03%]
Slc11a1基因敲低缓解小鼠心肌缺血再灌注损伤
Yilin Dong,Haoming Yang,Fan Yang et al.
Yilin Dong et al.
Background: Myocardial ischemia-reperfusion (MIR) injury remains the leading cause of adverse outcomes after myocardial infarction, and its prevention remains a major therapeutic challenge. ...
Zhining Zhang,Takumi Mikawa,Matilde E Lleonart et al.
Zhining Zhang et al.
The metabolic reprogramming known as the Warburg effect, in which cancer cells preferentially convert glucose to lactate even in the presence of oxygen, is a defining hallmark of malignant transformation. Rather than reflecting defective mi...
Acupuncture promotes post-stroke angiogenesis and neuroprotection through regulation of the DLL4/Notch1 signaling pathway [0.03%]
针刺通过调节DLL4/Notch1信号通路促进卒中后血管新生及神经保护作用
Weishuai Yin,Qin Li,Zetian Deng et al.
Weishuai Yin et al.
Objectives: Acupuncture, a core component of traditional Chinese medicine, is widely used for treating ischemic stroke; however, its neuroprotective mechanisms remain unclear. This study investigated the pro-angiogenic an...
Kinase signaling networks governing neuroinflammatory glial phenotypes: Current understanding and emerging targets [0.03%]
神经炎症胶质表型的激酶信号网络：当前理解与新兴靶点
Kyoungho Suk,Won-Ha Lee,Long Tai Zheng
Kyoungho Suk
Glial cells, particularly microglia and astrocytes, orchestrate the neuroinflammatory response in the central nervous system (CNS) through sequential phenotypic changes encompassing inflammatory activation, migration, phagocytosis, and tiss...
Marrow adipose tissue accumulation following anterior cruciate ligament reconstruction: A narrative review [0.03%]
前交叉韧带重建后骨髓脂肪组织积聚：综述性文章
Akinori Kaneguchi,Junya Ozawa
Akinori Kaneguchi
Marrow adipose tissue (MAT) is no longer considered a passive filler but a dynamic component of the bone marrow niche that actively regulates bone metabolism. This narrative review focuses on the dynamics of MAT accumulation following anter...
Clinicopathological and molecular features of wild-type gastrointestinal stromal tumors identified by targeted NGS [0.03%]
靶向NGS鉴定的野生型胃肠间质瘤的临床病理和分子特征
Shuang Xue,Chunxiao Li,Mei Li et al.
Shuang Xue et al.
Background: Wild-type (WT) gastrointestinal stromal tumors (GISTs) are a rare and molecularly heterogeneous subset of GISTs lacking KIT and PDGFRA mutations. These tumors pose significant diagnostic and therapeutic challe...