Glutamate signaling and transport around nodes of Ranvier and internodal myelin regions [0.03%]
节点氏节和隔髓鞘区间 glutamate信号传导和转运
José Javier Miguel-Hidalgo
José Javier Miguel-Hidalgo
The roles of glutamate as a major building block of proteins and as a key participant in numerous metabolic pathways are well established. Likewise, glutamate's function as a neurotransmitter-along with the distribution and actions of its r...
Histopathological and molecular mechanisms of multi-organ damage in heat stroke: Endothelial failure, immune crosstalk, and regulated cell death pathways [0.03%]
中暑多器官损伤的 histopathological 和分子机制：内皮功能障碍、免疫相互作用和程序性细胞死亡路径
Myoung Cheol Shin,Bo Hyun Jung,Joongbum Moon et al.
Myoung Cheol Shin et al.
Heat stroke is a life-threatening condition characterized by severe hyperthermia accompanied by central nervous system dysfunction and progressive multi-organ injury. Although rapid cooling remains the cornerstone of clinical management, ac...
Alginate gel embedding preserves antigenicity in free-floating brain sections [0.03%]
藻酸盐凝胶包埋保存自由漂浮脑切片的抗原性
Mihaela Abuzan,Andreea Cercel,Dirk M Hermann et al.
Mihaela Abuzan et al.
Free-floating cryosections are widely used in neuroanatomical and immunohistochemical studies due to their superior antigen preservation and unrestricted antibody penetration. However, long-term storage of these sections is vulnerable to fr...
Tanshinone IIA alleviates inflammation and apoptosis in myocardial ischemia-reperfusion injury by modulating the MALT1/NF-κB/NLRP3 signaling axis [0.03%]
丹参酮 ⅡA通过调节MALT1/NF-κB/NLRP3信号轴缓解心肌缺血再灌注损伤炎症和细胞凋亡
Huimin Yu,Yili Li,Yuehong Yang et al.
Huimin Yu et al.
Objective: Tanshinone IIA (Tan IIA), a bioactive compound from Salvia miltiorrhiza, protects cardiomyocytes against ischemia-reperfusion (I/R) injury. This study aims to elucidate its underlying molecular mechanisms. ...
HNMT promotes the motility-associated structures of breast cancer cells through the PI3K/Akt signaling pathway to promote tumor progression [0.03%]
hnmt通过pi3k/akt信号通路促进乳腺癌细胞运动相关结构以促进肿瘤进程
Hong Liu,Jianhui Zhang,Yanjun Zhao et al.
Hong Liu et al.
Background: Breast cancer (BC) is a tumor type that severely threatens the health and lives of women worldwide. Cancer cell motility often leads to the distant metastasis of BC. Histamine N-methyltransferase (HNMT) has be...
Molecular and clinicopathological characteristics of NTRK fusions in papillary thyroid carcinoma: Hospital experience with a literature review [0.03%]
重排在乳头状甲状腺癌中的分子和临床病理特征：医院经验与文献回顾
Hui Tang,Ting Sun,Jie Zhou et al.
Hui Tang et al.
Neurotrophic tyrosine receptor kinase (NTRK) fusions are rare but significant oncogenic drivers in papillary thyroid carcinoma (PTC). This study aims to delineate the clinicopathological and molecular characteristics of NTRK PTC and situate...
Characteristics of p53 and Smad4 immunohistochemistry in pancreatic ductal adenocarcinoma and validation by next-generation sequencing [0.03%]
胰腺导管腺癌中p53和Smad4免疫组化的特点及下一代测序验证
Ziqi Zhao,Juan Du,Wenyang Guo et al.
Ziqi Zhao et al.
Background: Mutations in four major driver genes-KRAS, CDKN2A, TP53, and SMAD4-are central to the pathogenesis of pancreatic ductal adenocarcinoma (PDAC) and critically inform diagnosis, therapeutic decision-making, and p...
Telocytes in skeletal muscle: Emerging players in homeostasis and repair/regeneration [0.03%]
肌细胞内的 telocyte：生理平衡及修复/再生中的新角色
Irene Rosa,Eloisa Romano,Mirko Manetti
Irene Rosa
Telocytes (TCs) have recently emerged as novel components of the skeletal muscle interstitium. They are distinguished from other stromal cells by their immunophenotypic profiles and, especially, unique ultrastructural traits. Specifically, ...
Methyltransferase 3 promotes v-set and transmembrane domain-containing 2-like protein expression to intensify ferroptosis-mediated prostate adenocarcinoma progression through the m6A methylation modification [0.03%]
甲基转移酶3通过m6A甲基化修饰促进v-集落刺激因子超家族成员表达以增强前列腺腺癌细胞铁死亡诱导的恶性进展
Jinming Li,Jun Jiang,Shaoxing Wang et al.
Jinming Li et al.
Background: Prostate adenocarcinoma (PRAD) is a common malignancy with high incidence in men. The role of v-set and transmembrane domain-containing 2-like protein (VSTM2L) in PRAD remains largely unreported. ...
Pathological changes in ventricular false chordae tendineae in patients with dilated cardiomyopathy [0.03%]
扩张型心肌病患者室腔假腱索的病理变化特点
Yaping Xu,Chenlei Zhou,Yuexin Yu et al.
Yaping Xu et al.
Objective: To investigate the pathological changes in ventricular false chordae tendineae in patients with dilated cardiomyopathy (DCM). Methods: ...