SAAS attenuates LPS-induced acute lung injury by targeting HMGB1-mediated NF-κB/NLRP3 inflammasome signaling [0.03%]
SAAS通过靶向HMGB1介导的NF-κB/NLRP3炎性小体信号传导减轻LPS诱导的急性肺损伤
Zhiyu Xie,Chong Liu,Xianhui Hong et al.
Zhiyu Xie et al.
Background: Acute lung injury (ALI) induced by lipopolysaccharide (LPS) involves severe inflammation and epithelial damage, necessitating effective therapeutic strategies. This study investigated the protective effects an...
GLI1-Altered neoplasms: From molecular alterations to morphologic and phenotypic features with formal recognition in the upcoming WHO Classification of soft tissue tumors [0.03%]
GLI1异常肿瘤：从分子改变到形态和表型特征，并在即将发布的软组织肿瘤WHO分类中正式认定
Raquel Rivas-Hernández,Francisco Giner,Elena Prados et al.
Raquel Rivas-Hernández et al.
GLI1-altered mesenchymal tumors represent a recently defined group of neoplasms molecularly characterized by GLI1 gene fusions or amplifications. Although initially thought to share similar molecular alterations, including pericytoma with A...
Identification of osteoblast cell-surface antigen regulating calcification as insulin receptor-related receptor, the alkali-sensor: A novel modulator of bone metabolism [0.03%]
骨细胞表面抗原的鉴定调节钙化作为胰岛素受体相关受体，碱度传感器：骨代谢的新调节因子
Hidenobu Hiura,Yukari Kyumoto-Nakamura,Tamer Badawy et al.
Hidenobu Hiura et al.
Background and aims: The regulatory mechanism of calcification mediated by osteoblasts is ambiguous. Previously, we had found a unique cell-surface A7 antigen recognized by an osteoblast-specific monoclonal antibody, whic...
Why ACL reconstruction fails to prevent post-traumatic osteoarthritis: A narrative review of mechanical and biological perspectives [0.03%]
ACL重建失败导致创伤性骨关节炎的发病的原因：机械学和生物学视角下的叙述性回顾
Akinori Kaneguchi
Akinori Kaneguchi
Anterior cruciate ligament (ACL) injury markedly increases the risk of post-traumatic osteoarthritis (PTOA), and anterior cruciate ligament reconstruction (ACLR), despite restoring knee stability and function, does not reliably prevent long...
Henagliflozin promotes mitophagy in renal tubular cells by activating AMPK/ULK1 to alleviate the progression of diabetic kidney disease [0.03%]
恩格列净通过激活AMPK/ULK1促进肾小管细胞线粒体自噬以缓解糖尿病肾脏疾病进展
Yanqiu Wang,Ziang Chen,Yali Zhang et al.
Yanqiu Wang et al.
Background: Diabetic Kidney Disease (DKD) is a leading cause of end-stage kidney disease. As an inhibitor of sodium-glucose cotransporter 2 (SGLT2), Henagliflozin (Hen) has been shown to have significant renoprotection ef...
Morphological, molecular, and electrophysiological aspects of skeletal muscle satellite cell-niche interactions: Focus on interstitial stromal non-myogenic cells [0.03%]
骨骼肌卫星细胞-微环境相互作用的形态学、分子和电生理学方面：关注间质基质非肌性细胞
Rachele Garella,Martina Parigi,Alessia Tani et al.
Rachele Garella et al.
Satellite cells (SCs) are recognized as the resident stem cells of adult skeletal muscles, essential for post-natal skeletal muscle growth and regeneration following focal myotrauma. In healthy muscle, SCs are quiescent, but in response to ...
Age-related morphological and histological changes in the dromedary camel thymus [0.03%]
单峰骆驼胸腺的年龄相关形态和组织学变化
Fahad A Alshanbari,Saleh M Albarrak,Yousef M Alharbi et al.
Fahad A Alshanbari et al.
The thymus is a key lymphoid organ responsible for T-cell development, yet information on its postnatal dynamics in the dromedary camel remains limited. In this study, we examined age-related morphological and histological changes in the ca...
Isofraxidin ameliorates CCl4-induced liver fibrosis in mice by inhibiting the NF-κB pathway [0.03%]
异紫草素通过抑制NF-κB途径改善四氯化碳致小鼠肝纤维化
Dongmei Wang,Xiaoming Li,Yingshi Su et al.
Dongmei Wang et al.
Objective: To investigate the anti-fibrotic effects of Isofraxidin (IF) on liver fibrosis and its underlying mechanisms. Methods: C57BL...
FOXO3/HMOX1 axis promotes melanoma progression by regulating ferroptosis and immune escape [0.03%]
FOXO3/HMOX1轴通过调节铁死亡和免疫逃逸促进黑色素瘤进展
Suzhi Ji,Maimaitiaili Hasimu,Junwei Du et al.
Suzhi Ji et al.
Background: Melanoma represents a highly aggressive form of skin cancer characterized by significant invasiveness and immune evasion capabilities. Although heme oxygenase-1 (HMOX1) participates in cellular stress response...
Immunohistochemical evaluation of CD44 expression and its correlation with clinicopathological factors and molecular markers (EGFR, STAT3, and lipid metabolism-related proteins) in oral squamous cell carcinoma [0.03%]
口腔鳞状细胞癌中CD44的表达及其与临床病理因素和分子标志物（EGFR、STAT3及脂质代谢相关蛋白）关联的免疫组化评价
Masakatsu Fukuda,Yudai Ogasawara,Leona Kashimata et al.
Masakatsu Fukuda et al.
CD44, a cell-surface glycoprotein involved in cell-cell interactions and adhesion, has been implicated in tumorigenesis and cancer stem cell (CSC) maintenance in various human malignancies. While its expression has been investigated in oral...