Frontotemporal dementia-associated protein "phosphorylated TDP-43" localizes to atherosclerotic lesions of human carotid and main cerebral arteries [0.03%]
与frontotemporal痴呆有关的蛋白质“TDP-43磷酸化”定位于人类颈动脉和大脑主要动脉粥样硬化部位
Takahiko Umahara,Toshiki Uchihara,Kentaro Hirao et al.
Takahiko Umahara et al.
The transactivation response DNA binding protein (TARDP) of 43 kDa (TDP-43) is a nuclear protein pivotal in RNA processing. Because phosphorylated (p) TDP-43 has been identified as a component of ubiquitin-positive and tau-negative inclusio...
The evaluation of the distribution of CD133, CXCR1 and the tumor associated macrophages in different molecular subtypes of breast cancer [0.03%]
评估不同分子亚型乳腺癌中CD133、CXCR1和肿瘤相关巨噬细胞的分布
Can Ilgın,Erdem Çomut,Çağlar Sarıgül et al.
Can Ilgın et al.
Breast cancer has different molecular subtypes, which determine the prognosis and response to the treatment. CD133 is a marker for cancer stem cells in tumor microenvironment with diagnostic/therapeutic importance. The tumor associated macr...
Hypertension accelerates age-related intrarenal small artery (IRSA) remodelling and stiffness in rats with possible involvement of AGEs and RAGE [0.03%]
高血压通过糖基化终产物及其受体RAGE介导促进大鼠肾内小动脉的衰老与硬化
Yajing Bai,Xiaoyun Shi,Yilang Ke et al.
Yajing Bai et al.
Objectives: To study changes in morphology, advanced glycation end products (AGEs) and the AGEs receptor, RAGE, that occur with ageing in intrarenal small arteries (IRSAs) of spontaneously hypertensive rats (SHRs) and to ...
Gema Esquiva,Jens Hannibal
Gema Esquiva
Melanopsin-expressing retinal ganglion cells (mRGCs) constitute a system in the mammalian retina used for irradiance detection, regulating non-image forming functions, such as photoentrainment of circadian rhythms, control of the pupillary ...
Age- and sex-associated changes in prosaposin and its receptors in the lacrimal glands of rats [0.03%]
大鼠泪腺中Prosaposin及其受体的年龄和性别相关变化
Farzana Islam,Md Sakirul Islam Khan,Hiroaki Nabeka et al.
Farzana Islam et al.
Prosaposin, a saposin precursor, is a potent neurotrophic factor found in several tissues and various biological fluids. Saposin-deficient patients have different ophthalmic disorders, indicating a relationship between ocular health and pro...
Ultrastructural changes of the human enteric nervous system and interstitial cells of Cajal in diverticular disease [0.03%]
人类肠神经系统的超微结构改变及卡哈尔细胞间质在憩室病中的变化
Paulius Alaburda,Jaune I Lukosiene,Audrys G Pauza et al.
Paulius Alaburda et al.
Background: In spite of numerous advances in understanding diverticular disease, its pathogenesis remains one of the main problems to be solved. We aimed to investigate the ultrastructural changes of the enteric nervous s...
Optimization of RNA extraction from laser captured microdissected glomeruli from formalin-fixed paraffin-embedded mouse kidney samples for Nanostring analysis [0.03%]
一种优化NanoString分析的小鼠肾福尔马林固定石蜡包埋样品激光捕获微解剖肾小球的RNA提取方法
Abigail Hay,Jean-Martin Lapointe,Arthur Lewis et al.
Abigail Hay et al.
Optimized protocols for the microdissection of specific areas from archival tissues and the subsequent RNA analysis are needed but challenging due to RNA degradation and chemical modifications. The aim of this study was to present the most ...
Morphological changes during the formation of amoebic liver abscess in vagotomized hamsters [0.03%]
迷走神经切断仓鼠阿米巴性肝脓肿形成过程中的一些形态学变化
Esperanza Sánchez-Alemán,Leticia María Lili-Carrillo,Martin Humberto Muñoz-Ortega et al.
Esperanza Sánchez-Alemán et al.
Amoebic liver abscess (ALA) is the main extra-intestinal complication caused by Entamoeba histolytica. Given the histological features of ALA in hamsters and the importance of the vagus nerve in the immune response, the aim of this study wa...
Small molecule GSK-3 antagonists play a pivotal role in reducing the local inflammatory response, in promoting resident stem cell activation and in improving tissue repairing in regenerative dentistry [0.03%]
小分子GSK-3拮抗剂在再生齿科学中发挥重要作用：降低局部炎症反应，促进居留干细胞活化及改善组织修复作用
Marco Tatullo,Irina Makeeva,Sandro Rengo et al.
Marco Tatullo et al.
Regenerative dentistry is attracting growing interest in the scientific community, mainly because of its translational and promising therapeutic approach. The latest research carried out by the scientific community are aimed at triggering t...
Arnulf H Koeppen,Jiang Qian,Alicia M Travis et al.
Arnulf H Koeppen et al.
Heart disease is an integral part of Friedreich ataxia (FA). In addition to cardiomyocyte hypertrophy, fiber necrosis, and inflammatory infiltration, sections show fibrosis and disorganized capillaries. We examined the left ventricular wall...