Squamous papilloma of the external ear in Southwest China: A large case series highlighting predominant HPV subtypes, pathologic features, and unique epidemiologic factors [0.03%]
中国西南地区外耳鳞状乳头状瘤的大样本病例系列：重点关注主要人乳头瘤病毒亚型、病理特征和独特的流行病学因素
Jun Zhou,Tianming Yang,Wenjuan Cheng et al.
Jun Zhou et al.
Squamous papilloma (SP) of the external ear is a rare benign neoplasm, with limited research on its associated human papillomavirus (HPV) infections and pathologic features. This study aims to provide a comprehensive analysis of the largest...
Tyrosine protein kinase ABL1 regulates the mTOR/ULK1 pathway to alleviate postoperative cognitive dysfunction in aged mice [0.03%]
酪氨酸蛋白激酶ABL1通过调节mTOR/ULK1信号通路改善老龄小鼠术后认知功能障碍
Chanjuan Chen,Jingwen Hao,Yuan Liu et al.
Chanjuan Chen et al.
Background: Postoperative cognitive dysfunction (POCD) is a common and serious complication in older adult patients. While the tyrosine kinase ABL1 has been implicated in neurodegenerative diseases, its specific role in P...
CD34+ cells contribute to cardiac remodeling during disease development [0.03%]
心肌病发病过程中CD34+细胞对心脏重塑的贡献
Hanwei Jin,Kai Chen,Qingbo Xu et al.
Hanwei Jin et al.
CD34, once considered solely a hematopoietic stem cell marker, is now recognized as a lineage interface identifying distinct tissue-resident progenitor populations that critically influence cardiac homeostasis and pathological remodeling. I...
Clinical-histological and genetic features of rare variants of melanoma [0.03%]
恶性黑色素瘤罕见亚型的临床病理和遗传特征
Gerardo Cazzato,Francesco Fortarezza,Costantino Ricci et al.
Gerardo Cazzato et al.
Melanoma is traditionally classified into a limited number of common clinicopathologic subtypes; however, routine clinical and histopathologic practice reveals a broad spectrum of rare variants and unusual morphologic patterns that pose sig...
Cantharidic acid causes mitochondrial dysfunction via the Nrf2/HO-1/GPX4 pathway to inhibit colorectal cancer progression [0.03%]
斑蝥素通过Nrf2/HO-1/GPX4信号通路诱导线粒体功能障碍抑制结肠癌进展
Yan Wei,Shulin Dai,Dongyun Zhang et al.
Yan Wei et al.
Background: Cantharidic acid (CA) is a cantharidin analog and has antitumor effects. This study aimed to investigate the antitumor activity of CA against colorectal cancer (CRC) and the underlying mechanisms of this activ...
Angioimmunoblastic T-cell lymphoma with lymphomatous effusion: Diagnostic challenges and cytology-based approaches [0.03%]
伴有淋巴瘤性积液的血管免疫母细胞性T细胞淋巴瘤的诊断难题及细胞学方法
Thanh Thao Nguyen,Anh Dung Vu,Sohsuke Yamada
Thanh Thao Nguyen
Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive peripheral T-cell lymphoma with a poor prognosis. Lymphomatous serous effusion, defined as the presence of malignant lymphoma cells in the pleural, pericardial, or peritoneal fluid,...
Exploring the potential application of roxadustat in chronic kidney disease-related osteoporosis based on the regulatory role of HIF-1α in bone metabolism [0.03%]
基于HIF-1α在骨代谢中调节作用的罗沙司他在慢性肾脏病相关性骨质疏松症中的潜在应用探索
Jingru Wang,Shoukui Xiang,Yuexian Xing
Jingru Wang
Oxygen is an essential element in the process of cellular oxidation, and hypoxia, a state of insufficient oxygen, can profoundly influence cellular adaptive responses through gene transcription, thereby impacting cell metabolism, angiogenes...
Lonp1 expression and correlation with mitophagy and immune infiltration markers in colon adenocarcinoma [0.03%]
Lonp1在结肠腺癌中的表达及其与线粒体自噬和免疫浸润标志物的相关性研究
Giada Zanini,Valentina Selleri,Giorgia Sinigaglia et al.
Giada Zanini et al.
LONP1, a mitochondrial ATP-dependent protease, plays a crucial role in mitochondrial homeostasis by regulating protein turnover and mitophagy. Recent studies have highlighted its upregulation in various cancers, including colorectal cancer ...
Membranous remodeling of basal infoldings in attenuated epithelial cells of dilated renal tubules under unilateral ureteral obstruction (UUO) in adult mouse kidney [0.03%]
成人单侧输尿管梗阻(UUO)肾脏扩张肾小管上皮细胞基底折褶的膜状重塑现象
Apussara Watthanakitphibun,Suthankamon Khrongyut,Atsara Rawangwong et al.
Apussara Watthanakitphibun et al.
Under unilateral ureteral obstruction (UUO) in mouse kidneys, comparing proximal and distal tubules and collecting ducts, the distal tubules exhibited the most pronounced dilation and epithelial attenuation. Basal infoldings, typically well...
Naoluotong granules inhibit necroptosis of neural cells and improve cerebral ischemia-reperfusion injury by regulating the RIP1/NIK/IKKα/NF-κB pathway [0.03%]
脑络通颗粒通过调控RIP1/NIK/IKKα/NF-κB信号途径抑制神经元细胞坏死性凋亡改善脑缺血再灌注损伤
Yajun Li,Wei Dong,Liangyong Li et al.
Yajun Li et al.
Background: Cerebral ischemia-reperfusion can cause structural changes in brain tissue and disrupt physiological functions. Naoluotong granules (NLT) exhibit significant neuroprotective effects on brain nerve cells and ar...