Electroacupuncture ameliorates learning and memory impairment by inhibiting inflammation and promoting synaptic plasticity via inhibition of the NF-KB/NLRP3 signaling pathway in cerebral ischemic rats [0.03%]
电针通过抑制NF-κB/NLRP3信号通路改善脑缺血大鼠学习记忆功能损伤及突触可塑性障碍的作用机制研究
Chuchu Huang,Guoyuan Pan,Dan Lu et al.
Chuchu Huang et al.
Objective: Electroacupuncture (EA) has a protective effect on cerebral ischemic injury. However, the specific mechanism of action of EA has not been studied. In this study, we investigated whether EA was involved in the t...
PIP5K3 upregulation correlates with unfavorable prognosis in patients with nasopharyngeal carcinoma [0.03%]
鼻咽癌患者中PIP5K3上调与预后不良相关
Szu-Chi Yao,Hung-Chang Wu,Ching-Chieh Yang et al.
Szu-Chi Yao et al.
Background: Nasopharyngeal carcinoma (NPC) is prevalent in East and Southeast Asia, with metastasis and recurrence leading to poor prognosis. Identifying prognostic biomarkers is essential. ...
UCHL1 enhances TSC1 transcription by stabilizing FOXO1 through deubiquitination in knee osteoarthritis [0.03%]
去泛素化酶UCHL1通过稳定FOXO1促进TSC1转录从而缓解膝骨关节炎病情发展
Yu Wang,Jiawei Lu,Chonghao Gu et al.
Yu Wang et al.
Ferroptosis has been shown to play a significant role in the pathophysiological progression of knee osteoarthritis (KOA). In this study, we sought to investigate the biological role of Ubiquitin C-terminal hydrolase 1 (UCHL1) in KOA and elu...
Cardioprotective mechanisms of Jiangfu Decoction against myocardial ischemia may involve regulation of the AMPK/PINK1/Parkin mitochondrial autophagy pathway [0.03%]
江肤汤抗心肌缺血的 cardioprotection 机制可能通过调节 AMPK/PINK1/Parkin 线粒体自噬途径实现
Yawei Zhao,Yiwei Hao,Chen Li et al.
Yawei Zhao et al.
Background: Jiangfu Decoction (JFD) is a classical traditional herbal medicine used to clinically treat ischemic heart disease (IHD). Nonetheless, the influence of JFD on myocardial ischemia (MI), along with its precise u...
Unraveling key molecules mediating the mechanisms of YAP deletion or inhibition in liver fibrosis regression through a multi-omics approach [0.03%]
通过多组学方法解析YAP缺失或抑制介导肝纤维化消退的关键分子机制
Siyuan Wang,Shihui Liu,Hejing Ruan et al.
Siyuan Wang et al.
Background: This study aimed to identify key molecules that potentially mediate the mechanisms by which YAP deletion or inhibition attenuates liver fibrosis. ...
Crumbs 3: Expression and biological significance in normal and neoplastic tissues [0.03%]
crumbs 3：在正常和肿瘤组织中的表达及生物学意义
Hidekazu Iioka,Akane Kitta-Kunihiro,Chiemi Ikude et al.
Hidekazu Iioka et al.
Cellular polarity plays a fundamental role in tissue organization and homeostasis, and its disruption is closely linked to tumorigenesis. Crumbs3 (CRB3), a conserved polarity protein, is essential for epithelial morphogenesis, tight-junctio...
Asiatic acid alleviates dexamethasone-induced muscle atrophy through regulating the Sirt1/PGC-1α/FOXO3 pathway [0.03%]
没食子酸通过调节Sirt1/PGC-1α/FOXO3信号通路缓解地塞米松诱导的肌肉萎缩
Dongfang Ji,Mingxin Cui,Chao Tian et al.
Dongfang Ji et al.
Background: Skeletal muscle atrophy, which results in muscular dysfunction and weakness, is associated with various factors, including aging, sepsis, chronic diseases, and long-term glucocorticoid therapy. Although asiati...
Penning decoction ameliorated pyroptosis in mice with lipopolysaccharide-induced endometritis through inhibition of the TLR4/NF-κB/NLRP3 pathway [0.03%]
Penning decoction通过抑制TLR4/NF-κB/NLRP3通路改善脂多糖诱导的小鼠子宫内膜炎的焦亡作用
Jiani Shi,Chen Chen,Yuqiong Yuan et al.
Jiani Shi et al.
Objectives: Endometritis, stemming from bacterial infection, manifests as persistent inflammation and may cause infertility. Penning decoction (PND) has been approved for clinical treatment of patients with endometritis. ...
Discordance of intrinsic subtype between primary tumor and lymph node metastasis in breast cancer patients [0.03%]
乳腺癌患者淋巴结转移灶与原发灶分子分型不一致的现象及其临床意义
Yoko Omi,Tomoko Yamamoto,Yoji Nagashima et al.
Yoko Omi et al.
The heterogeneity of cancer cells between primary breast tumors and lymph node (LN) metastases at the initial therapy remains unclear. This study aimed to determine whether intrinsic subtypes of LN metastasis differ from those of primary br...
Calycosin accelerates wound healing in diabetic rats by alleviating oxidative stress and promoting angiogenesis [0.03%]
甘草素通过减轻氧化应激和促进血管生成加速糖尿病大鼠伤口愈合
Wei Lu,Min Lu,Lifen Xue et al.
Wei Lu et al.
Background: Angiogenesis is a physiological process of diabetic wound healing. Although calycosin has been reported to exert protective effects on diabetic nephropathy, its role and mechanisms in diabetic wound healing re...