Amlodipine/ARB fixed-dose combinations for the treatment of hypertension: focus on amlodipine/olmesartan combination [0.03%]
氨氯地平/ARB类复方制剂治疗高血压的新进展:focus on 氨氯地平/奥美沙坦复方制剂
Steven G Chrysant
Steven G Chrysant
The incidence of hypertension continues to increase worldwide and, according to recent estimates, its incidence is approximately 30% of the U.S. population. However, the control of blood pressure (BP) to recommended levels of < 140/90 mmHg ...
Human protein C concentrates for replacement therapy in congenital and acquired protein C deficiency [0.03%]
先天性和获得性蛋白C缺乏的替代治疗用人类蛋白C浓缩物
Paul N Knoebl
Paul N Knoebl
The protein C pathway has an important function in regulating and modulating blood coagulation and ensuring patency of the microcirculation. Protein C deficiency leads to macro- or microvascular thrombosis. Hereditary severe protein C defic...
Gustavo A Heresi,Omar A Minai
Gustavo A Heresi
Systemic sclerosis (SSc) is a relatively rare chronic connective tissue disease characterized by varying degrees of skin fibrosis and visceral organ involvement. Pulmonary compromise, including pulmonary arterial hypertension and interstiti...
Seiji Nishino,Masashi Okuro
Seiji Nishino
Armodafinil is the (R)-enantiomer of the wakepromoting compound modafinil (racemic), with a considerably longer half-life of 10-15 hours. Armodafinil (developed by Cephalon, Frazer, PA, USA) was approved in June 2007 for the treatment of ex...
Urgency in overactive bladder: translating experimental data into clinical practice [0.03%]
过度活跃膀胱急迫性：实验数据向临床实践转化
Jean-Jacques Wyndaele,Stefan De Wachter
Jean-Jacques Wyndaele
In overactive bladder (OAB) syndrome, urgency is considered to be the key symptom that generates or affects all other symptoms. Urgency has been defined by the latest International Continence Society (ICS) terminology report as "the complai...
Ketoconazole: a review of a workhorse antifungal molecule with a focus on new foam and gel formulations [0.03%]
酮康唑：一种抗真菌分子的综述，重点介绍新型泡沫和凝胶制剂
Noah Scheinfeld
Noah Scheinfeld
Topical ketoconazole, an imidazole, has been a mainstay of treatment for fungal infections and seborrheic dermatitis. Ketoconazole interferes with the fungal synthesis of ergosterol, a constituent of cell membranes, and has other antifungal...
Gabapentin: a Ca2+ channel alpha 2-delta ligand far beyond epilepsy therapy [0.03%]
加巴喷丁ine：远不止抗癫痫的Ca2+通道α2-δ配体
Pasquale Striano,Salvatore Striano
Pasquale Striano
Gabapentin is an antiepileptic drug (AED) by design expected to mimic the action of the neurotransmitter gamma-aminobutyric acid (GABA). However, its principal proposed mechanism of action is the interaction with the alpha 2-delta subunit o...
Athanasios I Papathanasiou,John A Goudevenos,Dimitri P Mikhailidis et al.
Athanasios I Papathanasiou et al.
Clinical presentations of atherothrombotic vascular disease, i.e., acute coronary syndromes, cerebrovascular events and events associated with peripheral arterial disease, are the major causes of mortality and morbidity worldwide. Platelet ...
Vernakalant: pharmacology electrophysiology, safety and efficacy [0.03%]
vernakalant：药理学、电生理学、安全性和疗效
Gerald V Naccarelli,Deborah L Wolbrette,Soraya Samii et al.
Gerald V Naccarelli et al.
The development of new antiarrhythmic agents for the treatment of atrial fibrillation is advancing simultaneously on several fronts. The molecular structure of existing agents such as amiodarone is being modified in an attempt to improve sa...
Vishal Madaan
Vishal Madaan
Stimulants are extremely effective and safe and have been the mainstay for the pharmacological treatment of attention deficit hyperactivity disorder (ADHD) for many years. However, there have been some concerns regarding their abuse, especi...