Pharmacokinetic insights into atezolizumab SC: viability of extended dosing intervals beyond the standard regimen [0.03%]
阿特朱单抗皮下注射给药的药代动力学见解：探索性间隔给药方案（超出标准给药方案）的可行性研究
Vicente Gimeno-Ballester,Elena Herranz-Bayo,Cristina Trigo-Vicente
Vicente Gimeno-Ballester
Purpose: Atezolizumab is a monoclonal antibody against programmed cell death ligand 1 (PD-L1) used in oncology. With the intravenous formulation, the standard dose exceeds the established minimum effective concentration (...
Radiotherapy for intramedullary, leptomeningeal and epidural metastases: outcomes of an unusual and ominous complication [0.03%]
髓内、软脑膜和硬膜转移瘤放射治疗的结局：一种不寻常且预后不良并发症的治疗效果
Yuanyuan Lin-Liu,Héctor Pérez-Monter,Laura Martínez Ávila et al.
Yuanyuan Lin-Liu et al.
Purpose: Non-osseous intraspinal cord canal metastases (ISCM)-intramedullary, leptomeningeal and epidural metastases-are unusual complications with dismal prognosis. This study assessed clinical outcomes, local control (L...
SEOM-GEMCAD-TTD clinical guideline for the diagnosis and treatment of esophageal cancer (update 2025) [0.03%]
中国食管癌诊疗指南（2025版）(SEOM-GEMCAD-TTD)
Ana Fernández-Montes,Julia Alcaide,Ana Belén Custodio et al.
Ana Fernández-Montes et al.
Esophageal cancer represents an aggressive disease positioned as the seventh-leading cause of death from cancer. Esophageal cancer comprises two different diseases that should be distinguished by histology, i.e., squamous cell carcinoma and...
Polymorphisms and overexpression of immune checkpoints PD-1, PD-L1, and CTLA-4 in DLBCL: biomarker insights from a case-control study [0.03%]
DLBCL中免疫检查点PD-1、PD-L1和CTLA-4的多态性和过表达：来自病例对照研究的生物标志物信息
Habibe Sema Arslan Unal,Ozan Salim,Unal Atas et al.
Habibe Sema Arslan Unal et al.
Background: Diffuse large B-cell lymphoma (DLBCL) is a biologically heterogeneous lymphoma with variable treatment outcomes. Immune checkpoints are key regulators of tumor-immune interactions and important targets in canc...
Total neoadjuvant therapy for locally advanced rectal cancer in Spain: results from a national patterns-of-care survey by the SEOR-GI Group [0.03%]
西班牙局部晚期直肠癌新辅助治疗模式的全国调查（SEOR-GI组）
Sigfredo Elias Romero Zoghbi,Fernando López Campos,Abrahams Ocanto et al.
Sigfredo Elias Romero Zoghbi et al.
Purpose: To assess clinical practice patterns, technological availability, and national consensus in the management of locally advanced rectal cancer (LARC) in radiation oncology departments across Spain following the imp...
Single-cell and bulk transcriptomic profiling of metabolism-related lncRNAs reveals tumor heterogeneity and prognostic markers in non-small cell lung cancer [0.03%]
单细胞和批量转录组分析揭示了非小细胞肺癌中的代谢相关长链非编码RNA及其预后标志物
Bin Zhou,Xuelong Wang,Liwei Su et al.
Bin Zhou et al.
Purpose: Non-small cell lung cancer (NSCLC), including lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), exhibits marked tumor heterogeneity and poor prognosis. Metabolic reprogramming is a hallmark of c...
Disproportionality analysis of adverse events associated with degarelix: a real-world study from the FDA Adverse Event Reporting System (FAERS) database [0.03%]
基于FDA不良事件报告系统数据库的degarelix相关不良事件 disproportionality 分析：一项真实世界研究
Xiaojuan Lin,Liwei Guo,Yansheng Lin et al.
Xiaojuan Lin et al.
Purpose: This study aimed to detect adverse event (AE) signals associated with degarelix by analyzing data from the US FDA Adverse Event Reporting System (FAERS), so as to provide evidence for its safe clinical use. ...
An interpretable breast cancer risk stratification model via multi-omics integration: multi-method development and cross-cohort validation [0.03%]
一种可解释的乳腺癌风险分层模型：多组学整合、多种方法开发和跨队列验证
Weirong Xue,Xiaoxiao Zhu,Guangshuang Zhou et al.
Weirong Xue et al.
Background: Breast cancer remains a formidable global health challenge, and the absence of suitable survival guidance models persists, with most existing models suffering from methodological limitations, inadequate compar...
A FOXO1-G6PC transcriptional axis restrains renal cell carcinoma progression: multi-omics, epigenetic, and mechanistic evidence [0.03%]
Foxo1-G6pc转录轴通过多组学、表观遗传和机制证据抑制肾细胞癌的发展
Jieneng Wang,Bin Zhang,Hualan Ha et al.
Jieneng Wang et al.
Background: G6PC has emerged as a prognostic biomarker and potential therapeutic target in cancer, but its role in renal cell carcinoma (RCC) remains unclear. ...
Genome-wide DNA methylation analysis of pediatric medulloblastomas from a Brazilian cohort: an exploratory study [0.03%]
巴西一组儿童髓母细胞瘤的全基因组DNA甲基化分析：一项探索性研究
Hadassa G Ortiz,Ciliana Rechenmacher,William B Domingues et al.
Hadassa G Ortiz et al.
Background: DNA methylation profiling is a central tool for molecular classification of pediatric medulloblastoma. However, most reference datasets are derived from high-income countries, and the performance of establishe...