The impact of the PI3K/AKT/mTOR signaling pathway on trastuzumab resistance in HER2-positive gastric cancer [0.03%]
PI3K/AKT/mTOR信号通路对HER2阳性胃癌曲妥珠单抗耐药性的影响
Ali Salehi,Pier Paolo Piccaluga
Ali Salehi
Gastric cancer is a major cause of cancer-related mortality worldwide, frequently diagnosed at advanced stages due to its asymptomatic early course. HER2-positive gastric cancer represents a clinically significant subgroup, characterized by...
Global characterization of extrachromosomal circular DNA in cerebrospinal fluid of lung adenocarcinoma [0.03%]
肺癌脑膜转移外周血和脑脊液环状DNA的特征分析
Jing Liu,GuangMing Yi,XiaoYue Zhang et al.
Jing Liu et al.
Background: Non-small cell lung cancer (NSCLC) is a particularly aggressive subtype of lung cancer characterized by early metastasis and poor prognosis. Lung adenocarcinoma (LUAD) represents the most prevalent histologica...
Association of PD-L1 combined positive score with disease control and response kinetics with first-line pembrolizumab-based therapy in metastatic triple-negative breast cancer: results from routine clinical practice in Poland [0.03%]
PD-L1 合并阳性评分与波兰常规临床实践中晚期三阴性乳腺癌一线派姆单抗治疗的疾病控制和疗效起效速度关联：来自波兰的真实世界数据
Małgorzata Pieniążek,Katarzyna Świderska,Aleksandra Konieczna et al.
Małgorzata Pieniążek et al.
Background: Programmed death-ligand 1 (PD-L1) expression assessed by the combined positive score (CPS) is required for eligibility to first-line pembrolizumab-based therapy in metastatic triple-negative breast cancer (mTN...
Inequities in enrollment across clinical trial phases and the need for a Spanish perspective [0.03%]
临床试验各阶段入组的不平等及需要西班牙的观点
Javier Torres-Jiménez,Javier David Benítez Fuentes,Mónica Guillot Morales et al.
Javier Torres-Jiménez et al.
Early phase clinical trials (EPCT) are essential for evaluating new cancer treatments. However, disparities in patient enrollment persist, especially affecting older adults, minority groups, and individuals of lower socioeconomic status. In...
Subcutaneous immunotherapy as a catalyst for decentralized, oncologist-led cancer care: a mixed-methods analysis [0.03%]
皮下免疫治疗作为分散式肿瘤学家领导的癌症护理催化剂：一种混合方法分析
Eva Muñoz-Couselo,Julia Lostes,Giulia Pretelli et al.
Eva Muñoz-Couselo et al.
Background: The widespread adoption of immune checkpoint inhibitors has significantly improved outcomes across multiple solid tumors but has also increased pressure on hospital-based oncology services, particularly oncolo...
Radiomic and dosiomic machine learning models for predicting radiation-induced oral mucositis in head and neck cancer: a systematic review [0.03%]
头颈部癌症放射性口腔黏膜炎的影像组学和剂量组学预测模型系统评价
Lukas Mendes de Abreu,Raquel Molina Sanches,Alana Crescencio de Oliveira et al.
Lukas Mendes de Abreu et al.
Objective: To critically evaluate machine learning (ML) models developed for predicting radiation-induced oral mucositis (OM) in head and neck cancer (HNC) patients, emphasizing the contribution of advanced imaging biomar...
SAFE-IOERT prospective study: clinical outcomes of exclusive intraoperative radiotherapy in early breast cancer according to molecular subtype and tumor-infiltrating lymphocytes [0.03%]
术中单次放疗治疗早期乳腺癌的临床结果：分子亚型和瘤内浸润淋巴细胞的影响
G Oses,C Clavell,B González-Farré et al.
G Oses et al.
Purpose and objectives: Intraoperative electron radiotherapy (IOERT) can be applied during breast conserving surgery to treat invasive breast cancer. Tumor-infiltrating lymphocytes (TILs) are fundamental elements of the s...
Predicting time to local failure after gamma knife radiosurgery for melanoma brain metastases using survival machine learning [0.03%]
使用生存机器学习预测黑色素瘤脑转移伽玛刀放射手术后局部失败的时间
Jheremy S Reyes,Alexandros Bouras,Ajay Niranjan et al.
Jheremy S Reyes et al.
Background: Melanoma brain metastases treated with Gamma Knife radiosurgery show heterogeneous local control trajectories. Accurate prediction of time to local control loss could support risk stratification and follow-up ...
Image-guided brachytherapy in patients with inoperable FIGO 2009 stage IVB endometrial cancer who were not candidates for palliative surgery [0.03%]
对于不能耐受姑息性手术的FIGO 2009ⅣB期子宫内膜癌患者的影像引导后装放疗
Angeles Rovirosa,Yaowen Zang,Elaine Limkin et al.
Angeles Rovirosa et al.
Purpose: In patients with endometrial cancer (EC) with metastases at diagnosis, palliative treatment is the only therapy considered and to our knowledge there is no literature on the evolution of these patients following ...
Sex-based inequities in non-small cell lung cancer: gaps and opportunities across the care pathway [0.03%]
基于性别看非小细胞肺癌的不平等：诊治途径中的差距和机遇
Nesrine Mejri,Myriam Saadi,Mouna Ben Rejab et al.
Nesrine Mejri et al.
Background: Sex-related disparities in non-small cell lung cancer (NSCLC) remain incompletely characterized, particularly in low- and middle-income countries. We aimed to evaluate sex-based differences across the entire l...