PET-CT radiomics and artificial intelligence for predicting lymph node metastasis in cervical cancer: a systematic review and meta-analysis [0.03%]
基于PET-CT的放射组学和人工智能在宫颈癌淋巴结转移预测中的应用：系统评价和Meta分析
Xiaoyu Liu,Junqiang Lei
Xiaoyu Liu
Purpose: Preoperative identification of lymph node metastasis (LNM) in cervical cancer is crucial for guiding therapeutic strategies but remains clinically challenging. This study represents the first systematic meta-anal...
Moderate hypofractionation: long-term toxicity results of prostate bed radiotherapy (FRAME-PROSTATE) [0.03%]
中度低分割照射：前列腺床区放疗（FRAME-PROSTATE）的长期毒性结果
Federico Camilli,Saverio Caini,Chiara Doccioli et al.
Federico Camilli et al.
Purpose: Moderately hypofractionated radiotherapy (m-HRT) is a standard of care in the radical treatment of localized prostate cancer (PCa). Still, its role after radical prostatectomy (RP) is yet to be defined. We presen...
Letong Zhang,Jingwen Wang,Junming Hu et al.
Letong Zhang et al.
Advanced clear-cell renal cell carcinoma (ccRCC) management has become increasingly complex in the immunotherapy era, particularly with regard to first-line treatment selection and post-immunotherapy sequencing. This review summarizes curre...
Comparative efficacy and safety of nivolumab-based combination therapies (with ipilimumab or binimetinib) in patients with microsatellite-stable and microsatellite-instability-high metastatic colorectal cancer: a systematic review and meta-analysis [0.03%]
纳武利尤单抗联合伊匹木单抗或贝林妥欧单抗治疗微卫星稳定型和微卫星不稳定型转移性结直肠癌患者的疗效和安全性比较：系统评价和Meta分析
Hussain Abbas,Humayou Ahmed,Hafsa Shuja et al.
Hussain Abbas et al.
Background: Colorectal cancer (CRC) is the third most frequently diagnosed malignancy worldwide and the second leading cause of cancer-related mortality. Despite immune checkpoint inhibitors improving outcomes for patient...
Integrative bioinformatic and experimental analysis reveals prognostic and immunological roles of psychological stress-related genes in skin cutaneous melanoma [0.03%]
整合生物信息学和实验分析揭示心理压力相关基因在皮肤黑色素瘤预后和免疫中的作用
Bin Zheng,Yanglu Ge
Bin Zheng
Background: Skin cutaneous melanoma (SKCM) represents the most aggressive type of skin cancer. Accumulating evidence underscores the critical involvement of chronic psychological stress and depressive states in cancer dev...
Multimodality treatment and survival in primary cardiac malignancies: evidence from competing-risk and machine learning analyses [0.03%]
多模性治疗与原发心脏恶性肿瘤预后的关联：来自竞争风险和机器学习分析的证据
Md Roungu Ahmmad,Morshed Alam,Michael Baine et al.
Md Roungu Ahmmad et al.
Background: Primary cardiac malignancies are rare and highly aggressive, with limited clinical evidence to guide optimal treatment. This study evaluated the association between multimodal treatments and survival outcomes ...
First-line versus second-line use of selpercatinib in treatment of RET fusion-positive advanced non-small cell lung cancer: a cost-effectiveness analysis [0.03%]
塞尔帕替尼治疗RET融合阳性晚期非小细胞肺癌的一线与二线用药的成本效益分析
Kai Wang,Wenjie Liu
Kai Wang
Objective: This study aimed to evaluate the cost-effectiveness of using selpercatinib as a first-line treatment option or reserving it for second-line use versus relying exclusively on chemotherapy in managing RET fusion-...
Exploring tyrosine kinase inhibitors for HER2-positive breast cancer: comprehensive review on a complete pharmacology-molecular mechanisms, safety profiles, and insights from preclinical and clinical studies [0.03%]
HER2阳性乳腺癌的酪氨酸激酶抑制剂研究：药物分子机制、安全性及临床前和临床试验启示的全面综述
Meghraj V Suryawanshi,Rukaiya T Girase,Vishal S Bagul et al.
Meghraj V Suryawanshi et al.
Breast cancer involves complex molecular mechanisms, with elevated expression of various tyrosine kinase receptors correlating with unfavorable outcomes. Tyrosine kinase inhibitors are targeted cancer therapeutics that disrupt signaling pat...
Andrés Jesús Muñoz Martín,Angela Lamarca,Jesus M Banales et al.
Andrés Jesús Muñoz Martín et al.
Heterogeneity in primary gastrointestinal DLBCL: from clinical management to molecular mechanisms and treatment strategies [0.03%]
原发性胃肠道DLBCL的异质性：从临床管理到分子机制和治疗策略
Xiaohong Liu,Daoming Zhang,Le Xu et al.
Xiaohong Liu et al.
Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL), with approximately 30%-40% of cases occurring in extranodal organs. Primary gastrointestinal diffuse large B cell lymphoma (PGI-DLBCL) is a predomi...