Multigene panel testing reveals the spectrum of non-BRCA germline variants in BRCA1/2-negative breast, ovarian, and prostate cancer patients from a Turkish cohort [0.03%]
土耳其人群中BRCA1/2阴性乳腺癌、卵巢癌和前列腺癌患者的多基因检测结果揭示了非BRCA种系变异的谱型
Barıs Paksoy,Ozgur Erkal,Ayca Kocaaga
Barıs Paksoy
Background: Targeted multigene panel testing is increasingly used to assess hereditary cancer susceptibility beyond BRCA1/2. However, the distribution and clinical significance of pathogenic variants and variants of uncer...
A multidimensional pan-cancer analysis of CD47 and its role in promoting malignant phenotype in pancreatic adenocarcinoma [0.03%]
CD47的多维度泛癌分析及其在促进胰腺导管腺癌恶性表型中的作用
Shuangyan Su,Bihua Wu,Yuwei Li et al.
Shuangyan Su et al.
Background: CD47 is a widely expressed member of the immunoglobulin superfamily and plays important roles in cell proliferation, adhesion, and immune evasion. Previous studies have shown that CD47 contributes to tumor dev...
Prognostic value of the lactate-based modified cally score in postoperative gastric cancer patients admitted to the ICU [0.03%]
基于乳酸的改良Cally评分在术后胃癌ICU患者中的预后价值
Öztürk Taşkın,Veysel Garani Soylu,Ufuk Demir et al.
Öztürk Taşkın et al.
Background: Gastric cancer is a major cause of cancer-related mortality, and reliable postoperative risk prediction is essential in critically ill patients. The C-reactive protein-albumin-lymphocyte (CALLY) index reflects...
Role of cytoreductive surgery in the management of peritoneal metastases for gastrointestinal stromal tumors [0.03%]
腹腔镜探查和细胞减灭术在胃肠道间质瘤腹膜转移治疗中的作用
Irene López-Rojo,Paula Muñoz-Muñoz,Luis González Bayón et al.
Irene López-Rojo et al.
Peritoneal metastases represent the second most frequent site of dissemination in gastrointestinal stromal tumors (GIST), after the liver. Although associated with a worse prognosis than hepatic metastases, survival outcomes in peritoneal G...
Epithelial-mesenchymal transition and cancer-associated fibroblasts in tumor progression and therapy resistance: mechanistic convergence and therapeutic opportunities [0.03%]
上皮间质转化和癌相关成纤维细胞在肿瘤进展及治疗抵抗中的作用：机制联系与治疗机会
Dhiraj Kumar Singh,Rashmi Gupta,Umesh Kumar et al.
Dhiraj Kumar Singh et al.
Cancer progression and treatment failure are driven not only by tumor-intrinsic alterations but also by dynamic interactions within the tumor microenvironment (TME). Epithelial-mesenchymal transition (EMT) and cancer-associated fibroblasts ...
Establishment of insulin resistance-related ten-gene signature in endometrial cancer and identification of ACTL8 as a prognostic and immunological biomarker [0.03%]
建立与胰岛素抵抗相关的子宫内膜癌十基因特征并鉴定ACTL8作为预后和免疫生物标志物
Siyun Lu,Jie Xu,XiaoXiao Sun et al.
Siyun Lu et al.
Background: Endometrial cancer (EC) is a common gynecological tumor. Insulin resistance (IR) increases the risk of EC. However, the common molecular basis between the two remains unclear. This study aims to screen the com...
Genomic alterations and their correlation with metabolic-related genes in lung cancer [0.03%]
肺癌的基因组改变及其与代谢相关基因之间的关联性分析
Gauri Gaur,Niraj Kumar Jha,Lokesh Gambhir et al.
Gauri Gaur et al.
Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality worldwide, with 5-year survival rates below 21% primarily due to therapeutic resistance and metastatic progression. Genomic alterations in KRAS, EGFR, ...
Inherited cancer syndromes in adult oncology: a referral guide based on malignant tumor and polyp features [0.03%]
基于恶性肿瘤和息肉特征的成人肿瘤学遗传性癌症综合征转诊指南
Audrey Guilmot,Magali Belpaire,Eric Olinger et al.
Audrey Guilmot et al.
Background: Due to the challenges of identifying patients with hereditary cancer predispositions in oncology practice, we propose a comprehensive and practical tool intended for oncologists managing adult patients with ma...
Real-world effectiveness and safety of brigatinib in advanced ALK-positive NSCLC: a nationwide multicenter study by the Turkish Oncology Group [0.03%]
布加替尼治疗ALK阳性晚期NSCLC的真实世界疗效和安全性：土耳其肿瘤学组的全国多中心研究
Salih Tunbekici,Hamit Bal,Oguzcan Kınıkoglu et al.
Salih Tunbekici et al.
Background: Brigatinib, a next-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor, has demonstrated efficacy in pivotal trials in both pretreated and treatment-naïve patients with ALK-positive non-smal...
F León,S Moreno-López,J Mases et al.
F León et al.
Introduction and objectives: Cryotherapy (CT) is increasingly used as a primary treatment for prostate cancer (PC), though guideline recommendations remain limited. This study evaluates toxicity, including the use of hypo...