Ferrán Losa,Olatz Etxaniz,Alejandra Giménez et al.
Ferrán Losa et al.
Cancer of unknown primary (CUP) is defined as a heterogeneous group of tumors that appear as metastases for which a standard diagnostic work-up fails to identify the tissue of origin. There is now high-level evidence showing that actionable...
Assessing telomerase and Ki-67 protein expression in pre-invasive lesions and invasive cervical neoplasia with correlation to clinico-pathological parameters [0.03%]
临床病理参数相关的小宇宫颈病变和浸润性宫颈肿瘤中端粒酶及Ki-67蛋白表达的检测
Manal Masoud Musallam Al Awfi,Al Shifaa Ibrahim Said Al Wahaibi,Mohammad Arafa et al.
Manal Masoud Musallam Al Awfi et al.
Background and purpose: Cervical carcinoma, exhibits distinctive hallmarks, including sustained proliferation and replicative immortality. Ki-67 is a well-established marker of cell proliferation, while the presence of te...
Utilization of MRI-based radiomics nomogram for predicting HER2-zero, -low, and -overexpression breast cancer [0.03%]
基于MRI的影像组学预测HER2阴性、低表达和过表达乳腺癌的列线图模型
Licui Zhang,Qinghong Duan,Ting Zhao et al.
Licui Zhang et al.
Objective: This study sought to retrospectively investigate the clinical utility of a radiomics nomogram based on MRI for stratifying HER2 expression status in breast tumors into three categories. ...
Dynamics changes of spleen volume predict survival outcomes in unresectable hepatocellular carcinoma treated with tislelizumab plus lenvatinib [0.03%]
不可切除肝细胞癌患者接受信迪利单抗联合仑伐替尼治疗时，脾体积变化对生存预后的预测价值
Qingxun Zhou,Zhiyong Xiong,Hao Liang et al.
Qingxun Zhou et al.
Purpose: Dynamic changes in spleen volume (SpV) may reflect immune and hemodynamic alterations in hepatocellular carcinoma (HCC). This study aimed to evaluate the prognostic significance of SpV dynamics in patients with u...
Exercise inhibits proliferation and induces apoptosis of lung adenocarcinoma cells via the POU2F2-SPOCD1-PI3K/AKT signaling axis [0.03%]
运动通过POU2F2-SPOCD1-PI3K/AKT信号轴抑制肺腺癌细胞增殖并诱导其凋亡
Shujing Shi,Yumu Leng,Linfei Yang et al.
Shujing Shi et al.
Background: Lung adenocarcinoma (LUAD) is a prevalent and deadly form of lung cancer. Exercise has been shown to inhibit LUAD progression, yet the underlying molecular mechanisms remain unclear. The transcription factor P...
Integrative metabolomics and network pharmacology reveal the antifibrotic mechanisms of Gurigumu-13 in a rat model of hepatic fibrosis [0.03%]
整合代谢组学和网络药理学揭示古里古木配方13抗肝纤维化的作用机制
Shuping Tong,Anni,Sudulugeqi et al.
Shuping Tong et al.
Background: Liver fibrosis, a common pathological progression in chronic liver diseases, can lead to irreversible cirrhosis and hepatocellular carcinoma if untreated. Gurigumu-13, a traditional herbal formulation, has dem...
Iron, inflammation, and intestinal tumors: the crucial triad in colorectal cancer progression and therapy [0.03%]
铁、炎症和肠道肿瘤：结直肠癌进展和治疗中的关键三联因素
Mona Abediasl,Mehrnoush Siavash,Sina Sagharizadeh Esfahani et al.
Mona Abediasl et al.
Colorectal cancer (CRC), presently one of the main contributors to cancer death globally, has increasing evidence pointing towards improper iron homeostasis as an underlying mechanism driving both its induction and progression. This review ...
Pharmacokinetic insights into atezolizumab SC: viability of extended dosing intervals beyond the standard regimen [0.03%]
阿特朱单抗皮下注射给药的药代动力学见解：探索性间隔给药方案（超出标准给药方案）的可行性研究
Vicente Gimeno-Ballester,Elena Herranz-Bayo,Cristina Trigo-Vicente
Vicente Gimeno-Ballester
Purpose: Atezolizumab is a monoclonal antibody against programmed cell death ligand 1 (PD-L1) used in oncology. With the intravenous formulation, the standard dose exceeds the established minimum effective concentration (...
Radiotherapy for intramedullary, leptomeningeal and epidural metastases: outcomes of an unusual and ominous complication [0.03%]
髓内、软脑膜和硬膜转移瘤放射治疗的结局：一种不寻常且预后不良并发症的治疗效果
Yuanyuan Lin-Liu,Héctor Pérez-Monter,Laura Martínez Ávila et al.
Yuanyuan Lin-Liu et al.
Purpose: Non-osseous intraspinal cord canal metastases (ISCM)-intramedullary, leptomeningeal and epidural metastases-are unusual complications with dismal prognosis. This study assessed clinical outcomes, local control (L...
SEOM-GEMCAD-TTD clinical guideline for the diagnosis and treatment of esophageal cancer (update 2025) [0.03%]
中国食管癌诊疗指南（2025版）(SEOM-GEMCAD-TTD)
Ana Fernández-Montes,Julia Alcaide,Ana Belén Custodio et al.
Ana Fernández-Montes et al.
Esophageal cancer represents an aggressive disease positioned as the seventh-leading cause of death from cancer. Esophageal cancer comprises two different diseases that should be distinguished by histology, i.e., squamous cell carcinoma and...