Stable or not? unraveling the reliability of radiomic features in 4d-computed tomography in early-stage non-small cell lung cancer [0.03%]
稳定吗？探究四维CT在早期非小细胞肺癌中的放射组学特征的可靠性
Stefania Volpe,Aurora Gaeta,Maria Giulia Vincini et al.
Stefania Volpe et al.
Aim: Four-dimensional computed tomography (4D-CT) is the gold standard for radiotherapy planning in non-small cell lung cancer (NSCLC), yet its use in radiomics remains underexplored. This study proposes a reproducible, s...
Engineering the next generation of cellular therapies for solid tumors: multi-specific armored CARs and TME reprogramming strategies [0.03%]
下一代工程化细胞疗法治疗实体肿瘤：多特异性和武装CAR-T和肿瘤微环境重编程策略
Ling Mao,Lingfang Ding,Yunxia Ding
Ling Mao
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized hematologic oncology but remains largely ineffective against solid tumors, which evade immune attack through antigen heterogeneity, a suppressive tumor microenvironment (TME)...
Public Transcriptomic Data Mining for SCLC: From Candidate Ma rkers to Therapeutic Exploration [0.03%]
利用公共转录组数据对SCLC进行分析：从候选标志物到治疗探索
Hailin Liu,Fangyuan Qu,Guangyao Zhou et al.
Hailin Liu et al.
Background: Lung cancer, especially small-cell lung cancer (SCLC), is a widespread and deadly disease often detected at advanced stages, resulting in low five-year survival rates. This study aims to identify new genetic t...
Innovative immunotherapeutic strategies for thyroid cancer: challenges and opportunities [0.03%]
甲状腺癌的创新免疫治疗策略：挑战与机遇
Jinpeng Cui,Huali Fang,Changhua Qu
Jinpeng Cui
Thyroid cancer is the seventh most prevalent cancer worldwide, with a growing incidence and mortality rate. This malignancy encompasses distinct subtypes with diverse biological behaviors, clinical outcomes, and therapeutic vulnerabilities....
Ultra-rare TP53 and KRAS variants predict survival in ICI-treated solid tumours [0.03%]
超罕见的TP53和KRAS变异体可预测ICI治疗实体瘤患者的生存率
Vicente Javier Clemente-Suárez,Rodrigo Olivares,Rodrigo Yáñez-Sepúlveda et al.
Vicente Javier Clemente-Suárez et al.
Background: The prognostic relevance of ultra-rare TP53 and KRAS variants in advanced solid tumours treated with immune-checkpoint inhibitors (ICI) is unclear. ...
Correlation of the expression of mismatch repair proteins, CDX2, and SATB2 with the clinicopathological parameters of patients with colorectal carcinoma [0.03%]
错配修复蛋白、CDX2和SATB2的表达与结直肠癌临床病理参数相关性分析
Asem Shalaby,Heba Hany,Ahmed M Ramez et al.
Asem Shalaby et al.
Background: Mutations in mismatch repair (MMR) genes play a crucial role in the pathogenesis of colorectal carcinoma (CRC), accounting for 10% to 15% of sporadic cases and up to 90% of hereditary non-polyposis cases. Redu...
Prognostic ımpact of the modified Ryan tumor regression score in gastric and GEJ adenocarcinomas treated with neoadjuvant FLOT regimen [0.03%]
改良的Ryan肿瘤消退评分在新辅助FLOT治疗的胃及GEJ腺癌中的预后价值
Mehmet Akif Parlar,Burak Bilgin,Bülent Yalçın et al.
Mehmet Akif Parlar et al.
Objective: This study aimed to evaluate the prognostic significance of the Modified Ryan Tumor Regression Score (TRG) in predicting overall survival (OS) and disease-free survival (DFS) among patients with locally advance...
Recommendations for the development of an integrated lung cancer care process: an expert consensus report [0.03%]
肺癌综合诊疗流程构建专家共识及推荐措施
Margarita Majem,Patricia Alonso-Fernández,Pilar Garrido López et al.
Margarita Majem et al.
Objective: To identify key aspects of the lung cancer care process and generate prioritised recommendations to optimise coordination, quality, and equitable access to diagnosis and treatment. ...
SEOM-TTCC clinical guidelines for the treatment of head and neck cancer (2025) [0.03%]
中国临床肿瘤学会头颈肿瘤诊疗指南（2025）
Virginia Arrazubi,Lara Iglesias,Marc Oliva et al.
Virginia Arrazubi et al.
Squamous cell carcinoma of the lip, oral cavity, oropharynx, hypopharynx, and larynx comprises the ninth most common cancer in Spain. While alcohol and tobacco use have long been the primary etiological factors, the role of human papillomav...
Efficacy of concurrent hyperbaric oxygen therapy with chemoradiotherapy for glioma: a meta-analysis [0.03%]
高压氧联合放化疗治疗胶质瘤疗效的 Meta 分析
Qingfeng Cui,Ying Jin,Yinshan Tang et al.
Qingfeng Cui et al.
Objective: This study aimed to systematically evaluate the therapeutic efficacy and safety profile of concurrent hyperbaric oxygen therapy (HBOT) as an adjunct to chemoradiotherapy in patients with glioma. ...