Early access to medicines in Spain: a retrospective hospital study with a proposal for a regulatory change [0.03%]
西班牙的早期用药权：一项回顾性医院研究及监管改革建议
Jose Porcel-Maleno,Gerard Ronda-Roca,Arantxa Sancho-López et al.
Jose Porcel-Maleno et al.
Background: Medicines awaiting price and reimbursement (P&R) decisions represent a delicate situation in the Spanish NHS. The interval between marketing authorisation (MA) and PR averages 616 days, leaving patients withou...
Liquid biopsy in modern medicine: advancing diagnostics from molecular insights to clinical practice [0.03%]
液体活检在现代医学中的应用：从分子检测到临床实践的发展之路
Vivek Kumar Dhiman,Stuti Srivastava,Manju Kumari et al.
Vivek Kumar Dhiman et al.
Liquid biopsy is the analysis of tumour components in bodily fluids and is increasingly considered a complementary approach to conventional diagnostics. Although tissue biopsy is the gold standard in clinical diagnostics, this approach is i...
Modulation of HMGB1, PRF1, TRAIL, and M-CSF after TARGIT-IORT in breast-conserving surgery: defining a unique acute immune landscape [0.03%]
TARGIT-IORT后乳腺癌保留手术中HMGB1、PRF1、TRAIL和M-CSF的调节：定义独特的急性免疫景观
Yastira Ramdas,Catherine Worsley,Pieter Willem Meyer et al.
Yastira Ramdas et al.
Background: Targeted intraoperative radiotherapy (TARGIT-IORT) delivers a single high-dose boost to the tumor bed during breast-conserving surgery (BCS) and is now recommended only within clinical trials or registries. It...
Ovarian tissue cryopreservation in girls and adolescents at risk of gonadotoxicity: a 15-year experience in 159 patients from a referral program [0.03%]
青春期前女孩和青少年卵巢毒性高风险患者的卵泡浆冷冻保存经验报道：一项针对159名患者的研究结果
Mara Andrés Moreno,Javier Gómez Chacón,Patricia Torres Gómez et al.
Mara Andrés Moreno et al.
Purpose: To report a 15-year single-center experience of a pediatric fertility preservation program based on ovarian tissue cryopreservation (OTC), focusing on patient selection, program logistics, and endocrine and repro...
Evidence-steered medicine in oncology: network-aware micro-combinations that safeguard standard of care and potentially improve benefit-risk [0.03%]
肿瘤学中的基于证据的医学：保护标准治疗并有可能改善风险效益比的网络感知型微组合疗法
Konstantin Gurbanov
Konstantin Gurbanov
Standard oncology regimens often follow a dose-optimization paradigm: intensify a single agent until efficacy emerges or toxicity intervenes. Yet many targets sit in compensatory tumor-host networks that reroute around pathway pressure, whi...
Rethinking mucinous colorectal adenocarcinoma classification: evidence from histopathology and RAS mutations [0.03%]
黏液性结直肠腺癌的再分类：来自病理学和RAS突变的证据
Dorra Wider,Haifa Tounsi Guettiti,Monia Ardhaoui et al.
Dorra Wider et al.
Purpose: Mucinous adenocarcinoma (MAC) is a distinct and aggressive subtype of colorectal cancer (CRC), traditionally defined by > 50% mucinous component. However, evidence suggests tumors with lower mucin content may beh...
Xabier Mielgo-Rubio,Samantha Aso González,Eider Azkona Uribelarrea et al.
Xabier Mielgo-Rubio et al.
Borderline resectable NSCLC (BR-NSCLC) represents a complex clinical entity in which surgical resection is technically feasible but oncological benefit and margin negativity are uncertain. Advances in multimodal therapies, particularly the ...
Correction: Total neoadjuvant therapy for locally advanced rectal cancer in Spain: results from a national patterns‑of‑care survey by the SEOR‑GI Group [0.03%]
对西班牙SEOR-GI组全国诊疗模式调查中局部晚期直肠癌新辅助治疗的修正：结果报告
Sigfredo Elias Romero Zoghbi,Fernando López Campos,Abrahams Ocanto et al.
Sigfredo Elias Romero Zoghbi et al.
Red cell distribution width as a prognostic predictor for colorectal cancer: a meta-analysis [0.03%]
红细胞分布宽度作为结直肠癌预后预测因素的meta分析研究
Ruixue Fan,Yijiang Zhang,Junwei Feng
Ruixue Fan
Purpose: Red cell distribution width (RDW) is a simple, low-cost hematological indicator that reflects systemic inflammation and nutritional status. Nevertheless, its prognostic value in colorectal cancer (CRC) remains un...
Drug sensitivity testing of patient-derived bone sarcomas identifies selective kinase inhibitors for patients with refractory disease [0.03%]
基于患者的骨肉瘤药物敏感性检测可识别难治性疾病患者中的选择性激酶抑制剂
Christina Linder-Stragliotto,Panagiotis Tsagkozis,Swapnil Potdar et al.
Christina Linder-Stragliotto et al.
Objective: This study aimed to investigate the feasibility and predictive value in performing ex vivo drug sensitivity testing on bone sarcomas from patients with refractory disease and identify agents with potential ther...