Stereotactic body radiation therapy (SBRT) practice patterns for spine metastases in Spain: a national survey by the SRS/SBRT SEOR (Spanish Society of Radiation Oncology) Working Group [0.03%]
Rafael García,Maria José Pérez-Calatayud,Eva Corrales et al.
Rafael García et al.
Introduction: This study aims to evaluate the clinical practice in the treatment of spine metastases using stereotactic body radiation therapy (SBRT) among members of the SEOR (Spanish Society of Radiation Oncology) SRS/S...
SSX1 and TRIM58 expression stratifies lung squamous cell carcinoma by tumor immune microenvironment characteristics and informs potential immunotherapy responsiveness [0.03%]
Xiaoling Zhao,Chengyu Liu,Jiawen Sun et al.
Xiaoling Zhao et al.
Background: Lung squamous cell carcinoma (LUSC) remains a therapeutic challenge with limited biomarkers. The tumor immune microenvironment (TIME) is crucial for progression and immunotherapy response. Because SSX1 and TRI...
Predictive model for clear cell renal cell carcinoma: a novel model integrating sunitinib resistance and prognosis related genes and clinical factors [0.03%]
Jie Wang,Jun Dong,Long Kang et al.
Jie Wang et al.
Purpose: Sunitinib serves as the primary treatment for clear cell renal cell carcinoma (ccRCC). However, patients frequently develop resistance to it over time. Early prediction of sunitinib resistance and ccRCC prognosis...
Early access to medicines in Spain: a retrospective hospital study with a proposal for a regulatory change [0.03%]
Jose Porcel-Maleno,Gerard Ronda-Roca,Arantxa Sancho-López et al.
Jose Porcel-Maleno et al.
Background: Medicines awaiting price and reimbursement (P&R) decisions represent a delicate situation in the Spanish NHS. The interval between marketing authorisation (MA) and PR averages 616 days, leaving patients withou...
Liquid biopsy in modern medicine: advancing diagnostics from molecular insights to clinical practice [0.03%]
Vivek Kumar Dhiman,Stuti Srivastava,Manju Kumari et al.
Vivek Kumar Dhiman et al.
Liquid biopsy is the analysis of tumour components in bodily fluids and is increasingly considered a complementary approach to conventional diagnostics. Although tissue biopsy is the gold standard in clinical diagnostics, this approach is i...
Modulation of HMGB1, PRF1, TRAIL, and M-CSF after TARGIT-IORT in breast-conserving surgery: defining a unique acute immune landscape [0.03%]
Yastira Ramdas,Catherine Worsley,Pieter Willem Meyer et al.
Yastira Ramdas et al.
Background: Targeted intraoperative radiotherapy (TARGIT-IORT) delivers a single high-dose boost to the tumor bed during breast-conserving surgery (BCS) and is now recommended only within clinical trials or registries. It...
Ovarian tissue cryopreservation in girls and adolescents at risk of gonadotoxicity: a 15-year experience in 159 patients from a referral program [0.03%]
Mara Andrés Moreno,Javier Gómez Chacón,Patricia Torres Gómez et al.
Mara Andrés Moreno et al.
Purpose: To report a 15-year single-center experience of a pediatric fertility preservation program based on ovarian tissue cryopreservation (OTC), focusing on patient selection, program logistics, and endocrine and repro...
Evidence-steered medicine in oncology: network-aware micro-combinations that safeguard standard of care and potentially improve benefit-risk [0.03%]
Konstantin Gurbanov
Konstantin Gurbanov
Standard oncology regimens often follow a dose-optimization paradigm: intensify a single agent until efficacy emerges or toxicity intervenes. Yet many targets sit in compensatory tumor-host networks that reroute around pathway pressure, whi...
Rethinking mucinous colorectal adenocarcinoma classification: evidence from histopathology and RAS mutations [0.03%]
Dorra Wider,Haifa Tounsi Guettiti,Monia Ardhaoui et al.
Dorra Wider et al.
Purpose: Mucinous adenocarcinoma (MAC) is a distinct and aggressive subtype of colorectal cancer (CRC), traditionally defined by > 50% mucinous component. However, evidence suggests tumors with lower mucin content may beh...
Xabier Mielgo-Rubio,Samantha Aso González,Eider Azkona Uribelarrea et al.
Xabier Mielgo-Rubio et al.
Borderline resectable NSCLC (BR-NSCLC) represents a complex clinical entity in which surgical resection is technically feasible but oncological benefit and margin negativity are uncertain. Advances in multimodal therapies, particularly the ...