The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells [0.03%]
干细胞转录因子ZFP296转化NIH3T3细胞并促进癌细胞的非锚定依赖性生长
Yumi Mizoue,Tomomi Ikeda,Takako Ikegami et al.
Yumi Mizoue et al.
Cancer cells and embryonic stem (ES) cells share several biological properties, suggesting that some genes expressed in ES cells may play an important role in cancer cell growth. In this study, we investigated the possible role of zinc fing...
Chick chorioallantoic membrane: a valuable 3D in vivo model for screening nanoformulations for tumor antiangiogenic therapeutics [0.03%]
鸡绒毛尿囊膜：用于筛选肿瘤抗血管生成治疗纳米制剂的一个宝贵的三维体内模型
Anna Senrung,Tanya Tripathi,Divya Janjua et al.
Anna Senrung et al.
Drug discovery is an extensive process. From identifying lead compounds to approval for clinical application, it goes through a sequence of labor-intensive in vitro, in vivo preclinical screening and clinical trials. Among thousands of drug...
Lucas Unger,Andreas F Mathisen,Simona Chera et al.
Lucas Unger et al.
Differentiation of human induced pluripotent stem cells towards pancreatic islet endocrine cells is a complex process, involving the stepwise modulation of key developmental pathways, such as the Hedgehog signaling inhibition during early d...
Developmental Biology: from genes to functional organism - news from the 3rd Meeting of the Visegrád Group Society for Developmental Biology [0.03%]
发育生物学：从基因到功能有机体 - 来自维斯格拉德集团发育生物学第三届会议的新闻
Ewelina Trela,Agnieszka Walewska
Ewelina Trela
The third meeting of the Visegrád Group Society for Developmental Biology (V4SDB) was held on September 8th-10th, 2023 in Warsaw, Poland. It was a continuation of previous meetings, the first organized in the Czech Republic in 2018 and the...
Strontium-doped hydroxyapatite and its role in osteogenesis and angiogenesis [0.03%]
掺锶羟基磷灰石及其在骨形成和血管生成中的作用
Ling Ran,Lishuang Liu,Jingjing Gao et al.
Ling Ran et al.
For the past 50 years, hydroxyapatite (HA) has been widely used in bone defect repair because it is the main inorganic component of the mineral phase of a human bone. Extensive preclinical and clinical studies have shown that strontium (Sr)...
Evaluation of changes of apelin and apelin receptor (APJ) expression in cervix-uterus and placental axis in an LPS-induced preterm labor model [0.03%]
LPS诱导的早产模型宫颈-子宫及胎盘轴中aplin和aplin受体(APJ)表达变化的研究
Sema Avci,Ezgi Golal,Nuray Acar
Sema Avci
Although preterm birth is among the preventable causes of maternal and infant death, its mechanism has not yet been clarified. When evaluated in terms of the results, the psycho-social burden of mother-infant losses and the costs of rehabil...
Insights into the role of the Wnt signaling pathway in the regeneration of animal model systems [0.03%]
模式动物系统中Wnt信号通路在再生作用中的研究进展
Katarzyna S Walczyńska,Ling Zhu,Yujun Liang
Katarzyna S Walczyńska
Regeneration enables the regrowth and restoration of missing body parts. It is a common phenomenon among animals. However, only some species exhibit remarkable regeneration capabilities and can regenerate organs such as limbs, lenses or hea...
Valproic acid effects on human adipose-derived stem cell differentiation into oligodendrocytes and improved remyelination in a mouse model of Multiple Sclerosis [0.03%]
富马酸钠对人类脂肪来源干细胞向少突胶质细胞分化及改善小鼠多发性硬化模型再髓鞘化的影响
Sahar Ghosouri,Mohammad Bakhtiari,Soleimani Mitra et al.
Sahar Ghosouri et al.
Valproic acid (VPA), a neuroprotective agent and inhibitor of GSK3-β, along with human Adipose-Derived Stem Cells (hADSCs) have been proposed to be potential therapeutic agents for neurodegenerative disorders. In the present study, we have...
Polarized contact behavior in directionally migrating Xenopus gastrula mesendoderm [0.03%]
极化接触行为在分化迁徙的非洲爪蟾原肠胚中肠端细胞中的作用
Martina Nagel,Rudolf Winklbauer
Martina Nagel
The control of cell-cell adhesion and detachment is essential for collective migration and cell rearrangement. Here, we have used the contact behavior of Xenopus gastrula mesoderm explants migrating directionally on ectoderm conditioned sub...
Characterization of the developing axolotl nasal cavity supports multiple evolution of the vertebrate choana [0.03%]
虎纹火蜥蜴鼻腔的特征表明脊椎动物choana的多次进化具有偶然性
Batoul Chami,Bella Bates,Luke Shaheen et al.
Batoul Chami et al.
All tetrapods (mammals, birds, reptiles, and amphibians) share the ability to breathe with their mouths closed due to the formation of choanae, which are openings that allow communication between the nasal and oral cavities. In most fishes,...