Understanding megasporogenesis through model plants: contemporary evidence and future insights [0.03%]
借助模式植物理解大孢子发生：目前的证据和未来的启示
Inderdeep Kaur,Renu Kathpalia,Monika Koul
Inderdeep Kaur
The megasporangium serves as a model system for understanding the concept of individual cell identity, and cell-to-cell communication in angiosperms. As development of the ovule progresses, three distinct layers, the epidermal (L1), the sub...
Developmental relationship between junctional epithelium and epithelial rests of Malassez [0.03%]
牙龈结合上皮与malassez上皮剩余体的发育关系研究
Shubo Li,Shufang Li,Mingguo Cao
Shubo Li
Keratin 17 (K17) is thought to be a candidate target gene for regulation by Lymphoid Enhancer Factor-1 (Lef-1). K17 is a marker that distinguishes junctional epithelium (JE) from epithelial rests of Malassez (ERM). However, the relationship...
Enhancement of neural crest formation by mechanical force in Xenopus development [0.03%]
机械力可促进非洲爪蟾神经嵴的形成
Toki Kaneshima,Masaki Ogawa,Takayoshi Yamamoto et al.
Toki Kaneshima et al.
In vertebrate development, ectoderm is specified into neural plate (NP), neural plate border (NPB), and epidermis. Although such patterning is thought to be achieved by molecular concentration gradients, it has been revealed, mainly by in v...
Disrupted odontoblast differentiation and dentin dysplasia in Epiprofin-deficient mice [0.03%]
无Epiprofin小鼠中成牙本质细胞分化障碍及牙本质发育不全
Lucia Jiménez-Rojo,Susana de Vega,Gaskon Ibarretxe et al.
Lucia Jiménez-Rojo et al.
Tooth formation is a process tightly regulated by reciprocal interactions between epithelial and mesenchymal tissues. These epithelial-mesenchyme interactions regulate the expression of target genes via transcription factors. Among the regu...
Estrogen signaling in development: recent insights from the zebrafish [0.03%]
雌激素信号在发育中的作用：来自斑马鱼的最新见解
Hannah M Wesselman,Rebecca A Wingert
Hannah M Wesselman
While traditionally recognized as a sex hormone, estrogen has a potent effect on the development of tissues beyond those of the reproductive system. Estrogen synthesis enzymes and estrogen receptors are broadly expressed in vertebrate tissu...
The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells [0.03%]
干细胞转录因子ZFP296转化NIH3T3细胞并促进癌细胞的非锚定依赖性生长
Yumi Mizoue,Tomomi Ikeda,Takako Ikegami et al.
Yumi Mizoue et al.
Cancer cells and embryonic stem (ES) cells share several biological properties, suggesting that some genes expressed in ES cells may play an important role in cancer cell growth. In this study, we investigated the possible role of zinc fing...
Chick chorioallantoic membrane: a valuable 3D in vivo model for screening nanoformulations for tumor antiangiogenic therapeutics [0.03%]
鸡绒毛尿囊膜：用于筛选肿瘤抗血管生成治疗纳米制剂的一个宝贵的三维体内模型
Anna Senrung,Tanya Tripathi,Divya Janjua et al.
Anna Senrung et al.
Drug discovery is an extensive process. From identifying lead compounds to approval for clinical application, it goes through a sequence of labor-intensive in vitro, in vivo preclinical screening and clinical trials. Among thousands of drug...
Lucas Unger,Andreas F Mathisen,Simona Chera et al.
Lucas Unger et al.
Differentiation of human induced pluripotent stem cells towards pancreatic islet endocrine cells is a complex process, involving the stepwise modulation of key developmental pathways, such as the Hedgehog signaling inhibition during early d...
Developmental Biology: from genes to functional organism - news from the 3rd Meeting of the Visegrád Group Society for Developmental Biology [0.03%]
发育生物学：从基因到功能有机体 - 来自维斯格拉德集团发育生物学第三届会议的新闻
Ewelina Trela,Agnieszka Walewska
Ewelina Trela
The third meeting of the Visegrád Group Society for Developmental Biology (V4SDB) was held on September 8th-10th, 2023 in Warsaw, Poland. It was a continuation of previous meetings, the first organized in the Czech Republic in 2018 and the...
Strontium-doped hydroxyapatite and its role in osteogenesis and angiogenesis [0.03%]
掺锶羟基磷灰石及其在骨形成和血管生成中的作用
Ling Ran,Lishuang Liu,Jingjing Gao et al.
Ling Ran et al.
For the past 50 years, hydroxyapatite (HA) has been widely used in bone defect repair because it is the main inorganic component of the mineral phase of a human bone. Extensive preclinical and clinical studies have shown that strontium (Sr)...