TBC1D24 is likely to regulate vesicle trafficking in glia-like non-sensory epithelial cells of the cochlea [0.03%]
TBC1D24很可能是通过调节顶襄膜囊泡运输在耳蜗支持细胞中的作用来发挥作用
Jean Defourny
Jean Defourny
Mutations in the gene encoding Tre2/Bub2/Cdc16 (TBC)1 domain family member 24 (TBC1D24) protein are associated with a variety of neurological disorders, ranging from non-syndromic hearing loss to drug-resistant lethal epileptic encephalopat...
Enhancer-promoter communication in Drosophila developmental gene transcription [0.03%]
果蝇发育基因转录中的增强子-启动子通讯
George Hunt,Mattias Mannervik
George Hunt
Enhancers play an essential role in gene regulation by receiving cues from transcription factors and relaying these signals to modulate transcription from target promoters. Enhancer-promoter communications occur across large linear distance...
TGF-β signaling molecules in Hydra: role of BMP and BMP inhibitors during pattern formation [0.03%]
水母中的TGF-β信号分子：BMP和BMP抑制因子在模式形成过程中的作用
Lakshmi-Surekha Krishnapati,Surendra Ghaskadbi
Lakshmi-Surekha Krishnapati
Understanding the evolution of body plans has been one of the major areas of investigation in developmental and evolutionary biology. Cnidaria, the sister group to bilaterians, provides an opportunity to elucidate the origin and evolution o...
Wnt target gene Ascl4 is dispensable for skin appendage development [0.03%]
Wnt靶基因Ascl4在附属皮肤器官发生过程中可有可无
Verdiana Papagno,Ana-Marija Sulic,Jyoti P Satta et al.
Verdiana Papagno et al.
The development of skin appendages, including hair follicles, teeth and mammary glands is initiated through the formation of the placode, a local thickening of the epithelium. The Wnt/β-catenin signaling cascade is an evolutionary conserve...
Sonja Nykänen,Sanna Vuoristo
Sonja Nykänen
During the initial days of development, the embryo gradually shifts from reliance on maternally provided RNAs and proteins to regulation of its own development. This transition is marked by embryonic genome activation (EGA). While the facto...
Understanding megasporogenesis through model plants: contemporary evidence and future insights [0.03%]
借助模式植物理解大孢子发生：目前的证据和未来的启示
Inderdeep Kaur,Renu Kathpalia,Monika Koul
Inderdeep Kaur
The megasporangium serves as a model system for understanding the concept of individual cell identity, and cell-to-cell communication in angiosperms. As development of the ovule progresses, three distinct layers, the epidermal (L1), the sub...
Developmental relationship between junctional epithelium and epithelial rests of Malassez [0.03%]
牙龈结合上皮与malassez上皮剩余体的发育关系研究
Shubo Li,Shufang Li,Mingguo Cao
Shubo Li
Keratin 17 (K17) is thought to be a candidate target gene for regulation by Lymphoid Enhancer Factor-1 (Lef-1). K17 is a marker that distinguishes junctional epithelium (JE) from epithelial rests of Malassez (ERM). However, the relationship...
Enhancement of neural crest formation by mechanical force in Xenopus development [0.03%]
机械力可促进非洲爪蟾神经嵴的形成
Toki Kaneshima,Masaki Ogawa,Takayoshi Yamamoto et al.
Toki Kaneshima et al.
In vertebrate development, ectoderm is specified into neural plate (NP), neural plate border (NPB), and epidermis. Although such patterning is thought to be achieved by molecular concentration gradients, it has been revealed, mainly by in v...
Disrupted odontoblast differentiation and dentin dysplasia in Epiprofin-deficient mice [0.03%]
无Epiprofin小鼠中成牙本质细胞分化障碍及牙本质发育不全
Lucia Jiménez-Rojo,Susana de Vega,Gaskon Ibarretxe et al.
Lucia Jiménez-Rojo et al.
Tooth formation is a process tightly regulated by reciprocal interactions between epithelial and mesenchymal tissues. These epithelial-mesenchyme interactions regulate the expression of target genes via transcription factors. Among the regu...
Estrogen signaling in development: recent insights from the zebrafish [0.03%]
雌激素信号在发育中的作用：来自斑马鱼的最新见解
Hannah M Wesselman,Rebecca A Wingert
Hannah M Wesselman
While traditionally recognized as a sex hormone, estrogen has a potent effect on the development of tissues beyond those of the reproductive system. Estrogen synthesis enzymes and estrogen receptors are broadly expressed in vertebrate tissu...