Promyelocytic leukemia protein (PML) and stem cells: from cancer to pluripotency [0.03%]
早幼粒细胞白血病蛋白(PML)和干细胞:从癌症到多能性
Amalia P Vogiatzoglou,Fabien Moretto,Maria Makkou et al.
Amalia P Vogiatzoglou et al.
The promyelocytic leukemia protein (PML) is the core organizer of cognate nuclear bodies (PML-NBs). Through physical interaction or modification of diverse protein clients, PML-NBs regulate a multitude of - often antithetical- biological pr...
Spatial distribution of blood vessels in the chick embryo chorioallantoic membrane [0.03%]
鸡胚卵黄囊膜血管的空间分布
Diego Guidolin,Roberto Tamma,Tiziana Annese et al.
Diego Guidolin et al.
The chick embryo chorioallantoic membrane (CAM) is a useful tool with which to study both angiogenesis and anti-angiogenesis in vivo. CAM vascular growth pattern - including the way through vessels fills the available space - can be quite e...
Molecular characterization of the prostaglandin E receptor subtypes 2a and 4b and their expression patterns during embryogenesis in zebrafish [0.03%]
斑马鱼前列腺素E受体亚型2a和4b的分子特征及其在胚胎发生过程中的表达模式
Yongjun Han,Hongbo Chang,Hong Wu
Yongjun Han
The molecular expression profiles of zebrafish ep2a and ep4b have not been defined to date. Phylogenetic trees of EP2a and EP4b in zebrafish and other species revealed that human EP4 and zebrafish EP4b were more closely related than EP2a. Z...
Molecular characterization of the prostaglandin E receptor subtypes 2a and 4b and their expression patterns during embryogenesis in zebrafish [0.03%]
斑马鱼胚胎发育过程中前列腺素E受体亚型2a和4b的分子特征及其表达模式
Yongjun Han,Hongbo Chang,Hong Wu
Yongjun Han
The molecular expression profiles of zebrafish ep2a and ep4b have not been defined to date. Phylogenetic trees of EP2a and EP4b in zebrafish and other species revealed that human EP4 and zebrafish EP4b were more closely related than EP2a. Z...
Mitotic timing is differentially controlled by A- and B-type cyclins and by CDC6 associated with a bona fide CDK inhibitor Xic1 in Xenopus laevis cell-free extract [0.03%]
非洲爪蟾无细胞提取物中A和B型cyclin以及与真正的CDK抑制因子Xic1相关的CDC6对有丝分裂时间的差异化调控
Mohammed El Dika,Lisa Wechselberger,Bilal Djeghout et al.
Mohammed El Dika et al.
The timing of the M-phase is precisely controlled by a CDC6-dependent mechanism inhibiting the mitotic histone H1 kinase. Here, we describe the differential regulation of the dynamics of this mitotic kinase activity by exogenous cyclin A or...
Methods to generate and evaluate zebrafish models of human kidney diseases [0.03%]
生成和评估斑马鱼人肾脏疾病的模型的方法
Sana Fatma,Usharani Nayak,Rajeeb K Swain
Sana Fatma
Kidney-related disorders affect millions of people worldwide. A survey of chronic kidney disease (CKD) patients showed that the burden of kidney diseases is increasing every year. The global burden of disease (GBD) study 2017 ranked CKD as ...
A screen of kinase inhibitors reveals a potential role of Chk1 in regulating Hydra head regeneration and maintenance [0.03%]
激酶抑制剂的筛选揭示了Chk1在水螅头再生和维持中的潜在作用
Yunjin Lee,Varun Muddaluru,Shiraz Anwar et al.
Yunjin Lee et al.
The cnidarian Hydra possesses remarkable regenerative capabilities which allow it to regrow lost or damaged body parts in a matter of days. Given that many key regulators of regeneration and development are evolutionarily conserved, Hydra i...
Maternal and zygotic activin signaling promotes adequate pattern and differentiation of mesoderm through regulation of pluripotency genes during zebrafish development [0.03%]
母体和合子活化素信号通过调节斑马鱼发育过程中的多能性基因来促进中胚层的充足模式及分化
Shaghayegh Hasanpour,Soheil Eagderi,Hadi Poorbagher et al.
Shaghayegh Hasanpour et al.
To investigate the role of maternal Activin-like factors in the preservation of stemness and mesendoderm induction, their effects were promoted and inhibited using synthetic human Activin A or SB-505124 treatments, respectively, before the ...
Cend1 and Neurog2 efficiently reprogram human cortical astrocytes to neural precursor cells and induced-neurons [0.03%]
Cend1和Neurog2高效地重编程人皮质星形胶质细胞至神经前体细胞和诱导型神经元
Katerina Aravantinou-Fatorou,Seyyedeh Vejdani,Dimitra Thomaidou
Katerina Aravantinou-Fatorou
Direct reprogramming of glial cells into induced-neurons is a promising strategy for CNS repair after acute injury or neurodegenerative diseases. Grey matter astrocytes, which exhibit features of neural stem cells when activated, are an ide...
Birth and death of neurons in the developing and mature mammalian brain [0.03%]
发育中和成熟哺乳动物大脑中神经元的产生与消亡
Ioanna Dori,Chrysanthi Bekiari,Ioannis Grivas et al.
Ioanna Dori et al.
Although neuron birth and death are two contradictory processes, they serve the same purpose of the formation of the brain. They coexist during brain development, when cytoarchitecture and synaptic contacts are progressively established. It...