VPS34-IN1 potentiates STING-dependent activation in human CAL-1 cells [0.03%]
VPS34-IN1增强人类CAL-1细胞中的STING依赖性活化作用
Paulo Antas,Mariana D Machado,Fátima Leite-Pinheiro et al.
Paulo Antas et al.
Inhibition of the phosphatidylinositol kinase vacuolar protein sorting 34 (VPS34) with the pharmacological compound VPS34-IN1 has a range of effects on the dynamics of endosomes. While VPS34 inhibition has been previously suggested as a pot...
Inhibition of the RORC/GPX4 mediated ferroptosis regulatory axis suppresses tumor growth and alleviates enzalutamide resistance in prostate cancer [0.03%]
通过抑制RORC/GPX4介导的铁死亡调控轴抑制前列腺癌的发生发展及耐药产生
Yan Li,Bingqi Zhang,Zhongmin Zhang et al.
Yan Li et al.
Background: Patients with castration-resistant prostate cancer (CRPC) often develop resistance following long-term enzalutamide treatment. Building upon previous research, we aims to further explore the effect of ilicicol...
Cognitive-exercise dual-task training delays natural aging/D-galactose-induced cognitive decline in mice [0.03%]
认知锻炼双任务训练延缓自然老化和D-半乳糖致小鼠认知衰退
Zi-Man Zhu,Teng-Teng Dai,Rong Zhang et al.
Zi-Man Zhu et al.
Targeting the sirtuin 6-NF-κB p65 axis by 6-hydroxyhyoscyamine hydrobromide: a deacetylation-driven new therapy for diabetic wounds [0.03%]
盐酸山乌药碱通过靶向Sirtuin6-NF-κB p65轴促进糖尿病创面修复：去乙酰化的新策略
Junren Chen,Siqi Qin,Ziwei Xing et al.
Junren Chen et al.
Heat shock protein 90 stabilizes CD93 glycosylation to influence angiogenesis during diabetic wound healing [0.03%]
热休克蛋白90通过调节CD93糖基化影响糖尿病伤口愈合过程中的血管生成
Li Guo,Yan Liao,Yanfei Hu et al.
Li Guo et al.
Background: Angiogenesis, the formation of new blood vessels from preexisting vasculature, is often impaired in pathological conditions, such as a hyperglycemic environment. Angiogenesis is tightly regulated by a balance ...
HNF4A P2 isoform alleviates kidney fibrosis by inhibiting dedifferentiation of proximal tubular cells through JAG1/NOTCH signaling [0.03%]
HNF4A P2异构体通过JAG1 / NOTCH信号抑制近端小管细胞去分化从而缓解肾纤维化
Guiya Jiang,Xun Lu,Rui Cao et al.
Guiya Jiang et al.
Heterogeneity of glucose metabolism and uptake identifies distinct cancer cell and cancer stem cell phenotypes [0.03%]
葡萄糖代谢和摄入的异质性鉴别出不同的癌细胞和癌症干细胞表型
Zuzana Tylichova,Martin Krkoska,Vaclav Hrabal et al.
Zuzana Tylichova et al.
TGFβ pathway represses hepatic ribosome biogenesis and protein synthesis by regulating p70S6K-S6RP proteins [0.03%]
转化生长因子β信号通过调节p70S6K-S6RP通路抑制肝脏核糖体生成及蛋白质合成
Athanasios Stavropoulos,Vassiliki Stamatopoulou,Eleftherios Pavlos et al.
Athanasios Stavropoulos et al.
Background: Transforming growth factor-beta (TGFβ)-superfamily signaling has been implicated in the regulation of hepatocyte growth and regeneration after acute or chronic liver injury. However, the precise mechanisms un...
Methylation-induced silencing of AZGP1 enhances prostate cancer metastasis by stimulating tumoral glycolysis [0.03%]
甲基化引起的AZGP1基因沉默通过刺激肿瘤糖酵解促进前列腺癌转移
Lu Li,Jinguang Luo,Linyue Zhao et al.
Lu Li et al.
Background: Metastasis is the primary cause of mortality in patients with prostate cancer (PCa), yet effective treatments remain scarce. Identifying reliable biomarkers and understanding their underlying mechanisms is cru...
Mitochondria-endoplasmic reticulum contact sites in hepatocytic senescence [0.03%]
肝细胞衰老中的线粒体-内质网接触点
Pavitra Kumar,Mohsin Hassan,Frank Tacke et al.
Pavitra Kumar et al.
Inter-organelle communication via membrane contact sites (MCSs) is essential for the efficient functioning of eukaryotic cells, facilitating coordination among approximately 20 distinct organelles, each with unique metabolic profiles. Among...