BRD2 upregulation as a pan-cancer adaptive resistance mechanism to BET inhibition [0.03%]
BRD2上调作为对BET抑制产生适应性抵抗的泛癌机制
Suyakarn Archasappawat,Juliette Jacques,EunJung Lee et al.
Suyakarn Archasappawat et al.
Bromodomain and extraterminal motif (BET) inhibitors, such as JQ1, are promising cancer therapeutics that target epigenetic regulators, particularly BRD4. However, resistance to BET inhibitors (BETi) limits their clinical utility, necessita...
IRE1-XBP1driven induction of TMED9 stabilizes ATF6 during ER stress to promote cell survival [0.03%]
由IRE1-XBP1在内质网应激时诱导TMED9稳定ATF6以促进细胞存活
Chen Lenchisky,Areen Muhammad Majadly,Irena Bronshtein Berger et al.
Chen Lenchisky et al.
Background: The endoplasmic reticulum (ER) plays a central role in protein homeostasis by facilitating the folding, modification, and quality control of secretory and membrane proteins. Disruption of ER function results i...
Differentiation state affects PD-L1 expression in cutaneous melanoma: a systematic review [0.03%]
分化状态影响皮肤黑色素瘤中PD-L1的表达：系统性综述
Teitur Sævarsson,Hong Nhung Vu,Eiríkur Steingrímsson et al.
Teitur Sævarsson et al.
Background: Programmed death ligand-1 (PD-L1) is a widely used biomarker for immunotherapy in melanoma. The expression of PD-L1 in melanoma cells is known to vary considerably among and within patients' tumor samples. Rec...
Chicoric acid targets PYGL to normalize glycogenolysis-driven glycolysis to suppress non-small cell lung cancer [0.03%]
chicoric酸靶向PYGL以正常化糖原分解驱动的糖酵解来抑制非小细胞肺癌
Xingfa Huo,Helei Hou,Chuantao Zhang et al.
Xingfa Huo et al.
Background: Chicoric acid (CA), a bioactive natural compound found in Chicory and Echinacea purpurea, exhibits antiinflammatory, antioxidant, and apoptosis-inducing properties. However, its therapeutic potential and under...
Placental exosomal miR-372-3p drives preeclampsia progression by inducing mitochondrial damage in RVLM neurons [0.03%]
胎盘外泌体miR-372-3p通过诱导RVLM神经元线粒体损伤促进子痫前期进展
Shuai Zhang,Linping Wang,Bingjie Zhao et al.
Shuai Zhang et al.
Upregulated CCN1 from pleural mesothelial cells alters collagen I conformation and drives fibrosis via ITGB1/MAPK signaling [0.03%]
胸膜间皮细胞上调的CCN1改变I型胶原构象并通过ITGB1 / MAPK信号促进纤维化
Xiao-Lin Cui,Lin-Jie Song,Qian Li et al.
Xiao-Lin Cui et al.
DDX17-mediated raptor-dependent mTORC1 activation links autophagy inhibition and metabolic compensation in HCC development [0.03%]
DDX17介导的raptor依赖性mTORC1活化在HCC发展中连接自噬抑制和代谢补偿作用
Chaoxiang Lv,Na Luo,Chunli Wei et al.
Chaoxiang Lv et al.
Chemokines and chemokine receptors in metabolic dysfunction-associated steatohepatitis: pathogenic mechanisms and clinical implications [0.03%]
趋化因子及其受体在代谢功能异常相关steatohepatitis中的作用机制及临床意义
Min Yin,Yan Zhang,Shanshan Liu et al.
Min Yin et al.
LUCAT1 drives arecoline-induced head and neck cancer progression via STAT1-mediated transcriptional regulation [0.03%]
LUCAT1通过STAT1介导的转录调控驱动香蒲醇诱导的头颈部癌症进展
Hung-Han Huang,Guo-Rung You,Joseph T Chang et al.
Hung-Han Huang et al.
ENTPD3 as a novel regulator of endometrial receptivity: suppressing EMT via the ATP-P2Y2 axis in patients with recurrent implantation failure [0.03%]
ENTPD3作为调节子宫内膜容受性的新型因子通过ATP-P2Y2轴抑制复发性着床失败患者的EMT
Dan Mo,Zhonghong Zeng,Yongjin Luo et al.
Dan Mo et al.